Bioengineering core

生物工程核心

• 批准号: 10642594
• 负责人: Zahi A. Fayad
• 金额: $ 32.05万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642594
• 关键词: Biology; Biomedical Engineering; Bone Marrow; CD8-Positive T-Lymphocytes; CD8B1 gene; Cells; Chemistry; Deposition; Development; Dose; Drug Kinetics; Ensure; Epigenetic Process; Glycolysis; Goals; Human Resources; ITGAM gene; Image; Immune; Immunity; ImmunoPET; Immunotherapeutic agent; Intervention; Libraries; Liver; Mass Spectrum Analysis; Metabolic; Metabolism; Modeling; Monitor; Mus; Myeloid Cells; Positron-Emission Tomography; Process; Radioactive; Radiochemistry; Radioisotopes; Regimen; Research; Sampling; Spleen; Therapeutic; Therapeutic Studies; Tissues; Training; Transplantation; biomedical imaging; experience; experimental study; fluorodeoxyglucose; fluorophore; imaging agent; imaging probe; imaging study; in vivo; nanobiologic; nanobodies; nanolabel; nanomaterials; nanomedicine; nanotherapeutic; nanotherapy; novel; nuclear imaging; pharmacodynamic model; pharmacokinetics and pharmacodynamics; programs; success; therapeutic target

SUMMARY – CORE B Core B, the Bioengineering Core, will be directed by Dr. Zahi Fayad and serve all three Projects over all five years of the Program. The goals of the Core include: 1) Streamlining all therapeutic experiments by developing and providing trained immunity-inhibiting nanobiologics. 2) Facilitating the nuclear imaging projects by providing immuno-PET probes. 3) Ensuring the safe use and disposal of radioactive materials. The already developed nanobiologics and PET probes will be invaluable for the success of this Program Project. In addition, Core B’s strong chemistry experience will facilitate the development of additional nanotherapies and imaging probes as desired throughout this Project.

摘要 – 核心 B 核心 B，即生物工程核心，将由 Zahi Fayad 博士指导，为所有五个项目的所有三个项目提供服务 该计划的目标包括： 1) 通过开发和提供训练有素的免疫抑制来简化所有治疗实验 纳米生物学。 2）通过提供免疫PET探针促进核成像项目。 （三）确保放射性物质的安全使用和处置。 已经开发的纳米生物制剂和 PET 探针对于该计划项目的成功至关重要。 此外，Core B 丰富的化学经验将促进其他纳米疗法的开发和 在整个项目中根据需要使用成像探头。