NICHD Cooperative Multicenter Neonatal Research Network

NICHD 多中心新生儿合作研究网络

基本信息

批准号：
7610888
负责人：
KATHLEEN A KENNEDY
金额：
$ 23.44万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-07-17 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7610888
关键词：
Admission activity Advocate Award Beds Benchmarking Bioethics Biometry Chairperson Childhood Clinical Research Commit County Hospitals Dedications Discipline of obstetrics Disease Doctor of Philosophy Emergency treatment Enrollment Epidemiology Evidence Based Medicine Evoked Potentials, Auditory, Brain Stem Faculty Funding General Hospitals Glutamine Health Services Research Hospitals Housing Infant Journals Laparotomy Magnetic Resonance Imaging Manuscripts Master&apos s Degree Mentored Patient-Oriented Research Career Development Award Methods Mexican Americans Multicenter Neonatal Research Network National Institute of Child Health and Human Development Neonatal New England Observational Study Operative Surgical Procedures Perinatal Perinatal Epidemiology Phototherapy Population Private Hospitals Prophylactic treatment Protocols documentation Publishing Randomized Controlled Clinical Trials Research Research Personnel Research Training Review Committee Role Seizures Site Surgeon Testing Training Programs Vitamin A base follow-up health care economics high risk inhaled nitric oxide member natural hypothermia programs

项目摘要

DESCRIPTION (provided by applicant): OVERVIEW. UT Houston is a member of both the MFM and Neonatal Research Networks. It provides the following to the Neonatal Network: 1. A large, high-risk, and growing population. In 2003, we had a total of 9212 deliveries, 1181 NICU admissions, & 369 VLBW infants in our 2 hospitals which house 136 total NICU beds: Memorial Hermann Hospital (MHH), a private hospital with a large referral base, and Lyndon Baines Johnson General Hospital, (LBJ), a county hospital serving a largely Mexican American population; 2. High total enrollment in Network studies. We ranked 3rd of 16 Network centers in the Hypothermia & Benchmarking Trials, 2nd in the Phototherapy & Glutamine Trials, and 1st in the Premie Inhaled Nitric Oxide Trial; 3. A PI & CoPI skilled in clinical research & committed to the Network. The PI is Jon Tyson, MD, MPH, Director of the Center for Clinical Research and Evidence Based Medicine & recipient of the Douglas K. Richardson Award for perinatal and pediatric healthcare research and the Distinguished Educator Award from the Association of Clinical Research Training Program Directors. The CoPI is Kathleen Kennedy, MD, MPH, Director of the Perinatal Epidemiology Program and the Master's Degree Program in Clinical Research. They have served as PI and CoPI for the past 14 years (10 in Dallas & 4 in Houston) and are known for their dedication to exemplary research & helping other investigators. Dr. Tyson chaired the Vitamin A Committee (follow-up findings recently published), directs the Concurrent Research Committee, and is the only PI to have served continuously on the Protocol Review Committee since its inception. He has also been highly involved in the Hypothermia Trial (in press, New England Journal); 4. Multiple talented faculty taking major roles in Network research. These include a) Brenda Morris, MD who is directing the Phototherapy Trial (enrollment now completed; n = 1973 ELBW infants) and is site director for the SUPPORT Trial; b) Martin Blakely, MD, MS, a pediatric surgeon & K23 recipient who directed the recently completed the NEC Observational Study (1st manuscript published; 2nd in review). With Dr. Tyson, he is proposing a major trial based on the results; c) Robert Lasky, PhD, an NIH-funded neuropsychologist who is directing an important substudy of auditory brainstem evoked responses in the Phototherapy Trial (>50% of enrollment from UT Houston); d) Nehal Parikh, DO, a K23 award recipient, who is the site director for the ongoing aEEG study, the MRI secondary study of the Support Trial, and the proposed seizure prophylaxis trial; e) Sue Ramin, MD, PI of the MFM Network and advocate for Neonatal Network studies; and f) Larry Gilstrap, MD, Chairman of Obstetrics, Co PI of the MFM Network, and Neonatal Network Advisory Board member; 5. Methodological & multi-disciplinary expertise. The Center that Dr. Tyson directs provides ready access to 21 faculty with expertise in bioethics, biostatistics, epidemiology, health care economics, and health services research.

描述（申请人提供）：概述。 UT休斯顿是MFM和新生儿研究网络的成员。它为新生儿网络提供了以下内容：1。大型高风险和不断增长的人口。 In 2003, we had a total of 9212 deliveries, 1181 NICU admissions, & 369 VLBW infants in our 2 hospitals which house 136 total NICU beds: Memorial Hermann Hospital (MHH), a private hospital with a large referral base, and Lyndon Baines Johnson General Hospital, (LBJ), a county hospital serving a largely Mexican American population; 2。网络研究中的总入学人数高。我们在体温过低试验中排名第三，在16个网络中心中排名第三，在光疗和谷氨酰胺试验中排名第2，在Premie吸入一氧化氮试验中排名第1； 3。专门用于临床研究并致力于网络的PI和COPI。 PI是乔恩·泰森（Jon Tyson），医学博士，MPH，临床研究和证据医学中心主任，哥伦斯·K·理查森（Douglas K. COPI是围产期流行病学计划和临床研究硕士学位计划的MPH医学博士Kathleen Kennedy。在过去的14年中，他们一直担任PI和COPI（在达拉斯（Dallas）和休斯顿（Houston）4），并以其致力于示例性研究和帮助其他研究人员而闻名。泰森博士主持了维生素A委员会（最近发布的后续调查结果），指导并发研究委员会，并且是自成立以来唯一在协议审查委员会中不断服务的PI。他还高度参与了体温过低的试验（在新英格兰杂志上出版社）； 4。多个才华横溢的教师在网络研究中扮演重要角色。其中包括指挥光疗试验的医学博士Brenda Morris（现已完成； n = 1973 ELBW婴儿），并且是支持试验的现场主任； b）Martin Blakely，医学博士，MS，是一名儿科外科医生和K23接受者，他指挥了最近完成的NEC观察性研究（第1手稿；第二次手稿；第二次审查）。在泰森博士的情况下，他根据结果提出了一项重大审判。 c）罗伯特·拉斯基（Robert Lasky）博士，是一名由NIH资助的神经心理学家，他正在指导听觉脑干的重要子宫脑在光疗试验中引起反应（> UT休斯顿的入学率> 50％）； D）Nehal Parikh，Do，K23奖励获得者，他是正在进行的AEEG研究的现场主任，支持试验的MRI二级研究以及拟议的癫痫发作预防试验； e）MFM网络的PI Sue Ramin和新生儿网络研究的倡导者；和F）MFM网络妇产科主席和新生儿网络咨询委员会成员的妇产科主席Larry Gilstrap； 5。方法论和多学科专业知识。泰森（Tyson）指示的中心可随时可以访问21位具有生物伦理学，生物统计学，流行病学，卫生保健经济学和卫生服务研究的教师。