NICHD Maternal Fetal Medicine Units Network

NICHD 母胎医学单位网络

• 批准号: 7612689
• 负责人: John M Thorp
• 金额: $ 76.98万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-18 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7612689
• 关键词: African American; Antioxidants; Area; Arts; Birth; Birthing Centers; Caring; Child health care; Clinic; Clinical; Clinical Nutrition; Clinical Research; Clinical Trials; Clinics and Hospitals; Cohort Studies; Commit; Communities; Computer Assisted; Consent Forms; Consultations; Country; County; Coupled; Databases; Development; Disease; Doctor of Philosophy; Encephalopathies; Enrollment; Faculty; Follow-Up Studies; Funding; Health; Healthcare; Hispanics; Hydroxyprogesterone Caproate; Hypothyroidism; Indigent; Inflammatory; Institution; Knowledge; Laboratories; Laboratory Assistant; Lead; Leadership; Magnesium Sulfate; Medicaid; Metabolic; Morbidity - disease rate; National Institute of Child Health and Human Development; Nature; Neonatal; Nurseries; Nurses; Nursing Research; Nutritional Study; Observational Study; Oral; Outcome Study; Outpatients; Pamphlets; Participant; Patient Care; Patients; Performance; Perinatal; Perinatal Epidemiology; Physicians; Population; Positioning Attribute; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Premature Birth; Private Practice; Protocols documentation; Randomized Clinical Trials; Recruitment Activity; Research; Research Activity; Research Ethics Committees; Research Infrastructure; Research Personnel; Resources; Risk; Screening procedure; Services; Site; Stable Populations; Substance abuse problem; System; Systemic disease; Telephone Interviews; Triplet Multiple Birth; Twin Multiple Birth; United States National Institutes of Health; Woman; Women' s Health; Work; base; capitate bone; computerized; cost; data management; experience; fetal; fetal medicine; follow-up; graduate student; high risk; improved; member; patient population; population based; prenatal; racial and ethnic; success

DESCRIPTION (provided by applicant): As a new member of the Network, the UNC MFMU site has completed four randomized clinical trials and one observational study; is conducting follow-up studies for two trials; and has five trials ongoing. We have consistently ranked in the top half of overall recruitment among all network sites and excelled at Hispanic recruitment. This track record as a strong site, coupled with our tradition of excellence in clinical trials research and perinatal epidemiology makes us ideally suited to continue as a highly productive member of the Network. We have assembled a talented and committed team of physicians, research fellows, graduate students, research nurses, clinical research assistants, laboratory staff, and other investigators in our Perinatal Research Core, an alliance of investigators dedicated to understanding and improving pregnancy outcomes through state-of-the-art research. The Core is supported by a well-established infrastructure consisting of clinical tracking systems, data management resources, and specialized research services such as computer assisted telephone interviewing facilities, an NIH Clinical Nutrition Research Center, one of the top General Clinical Research Centers in the nation, a Comprehensive Center for Inflammatory Disorders, the Center for Oral and Systemic Diseases, and the Center for Women's Health Research. With the addition of Rex Healthcare in this application, our sites have more than 13,000 births each year, 33% of which are high-risk by virtue of maternal co-morbidities, including substance abuse, fetal anomalies, pregnancy complications, or preterm birth risk profile, including multiple gestations. UNC and WakeMed provide virtually all of the high-risk prenatal clinic and hospital-based care for our prenatal population because of a system of low-risk community clinics staffed by non-OB/GYNs using uniform screening and referral protocols. Patients from these clinics give birth at UNC or WakeMed. Overall, the majority of prenatal patients at WakeMed and UNC are indigent: 55% at UNC and 64% at WakeMed have Medicaid or are self-pay; 45% at UNC and 36% at WakeMed have some form of private coverage. The Rex patient population is predominately lower risk patients and the majority have some form of private coverage. Rex has a large birthing center and facilities where patients from more than 30 private practices in Wake County give birth. We currently work with 18 of these practices in other NIH-funded research. Affiliation with Rex will further broaden our base for outpatient recruitment. Racial and ethnic diversity in our recruitment has been strong with 42% white participants, 29% Hispanics, and 27% African Americans. UNC and WakeMed have Level 3 neonatal care units, and Rex has a Level 2 nursery. UNC is simultaneously applying to join the Neonatal Research Network this year. Together, our three partner institutions bring more than fifteen years of productive multi-site research, experienced investigators, state-of-the-art care facilities, a stable population, ongoing enhancements of computerized perinatal databases, and commitment to excellence in collaborative research as part of the MFMU.

描述（由申请人提供）：作为网络的新成员，UNC MFMU网站已完成四项随机临床试验和一项观察性研究。正在进行两项试验的后续研究；并正在进行五次试验。我们一直在所有网络网站中始终在整体招聘的上半场排名，并在西班牙裔招聘方面表现出色。这一记录是一个强大的地点，再加上我们在临床试验研究和围产期流行病学方面的卓越传统，使我们非常适合继续成为该网络的高产成员。我们组建了一个有才华的医生，研究研究员，研究生，研究护士，临床研究助理，实验室工作人员和其他研究人员的团队，这是我们的围产期研究核心，这是一个致力于通过先进的研究来理解和改善怀孕成果的研究人员的联盟。核心得到了公认的基础设施，包括临床跟踪系统，数据管理资源和专业研究服务，例如计算机辅助电话访谈设施，NIH临床营养研究中心是全国最大的一般临床研究中心之一，全国全面的炎症性疾病中心，炎症性疾病中心，口腔和系统性疾病中心，妇女和健康研究中心。随着本应用中的REX医疗保健的增加，我们的网站每年有13,000多个分娩，其中33％由于母亲的合并症，包括滥用药物，胎儿异常，妊娠并发症或早产风险，包括多种孕育，其中33％是高风险的。 UNC和Wakemed实际上为我们的产前人群提供了几乎所有高危产前诊所和基于医院的护理，因为使用统一的筛查和推荐方案，由非OB/GYN组成的低风险社区诊所系统。这些诊所的患者在UNC或Wakemed时出生。总体而言，Wakemed和UNC的大多数产前患者贫困：UNC的55％，Wakemed的64％患有医疗补助或自付额； UNC的45％，Wakemed的36％具有某种形式的私人保险。雷克斯患者人群主要降低风险患者，大多数患者具有某种形式的私人保险。雷克斯（Rex）有一个大型的分娩中心和设施，在威克县（Wake County）的30多种私人练习中，雷克斯（Rex）分娩。目前，我们在其他NIH资助的研究中与其中的18种实践合作。与雷克斯的隶属关系将进一步扩大我们的门诊招聘的基础。我们招募的种族和种族多样性与42％的白人参与者，29％的西班牙裔和27％的非洲裔美国人有关。 UNC和Wakemed具有3级新生儿护理部门，Rex拥有2级托儿所。 UNC同时申请今年加入新生儿研究网络。我们的三个合作伙伴机构共同带来了超过15年的生产性多站点研究，经验丰富的研究人员，最先进的护理设施，稳定的人口，对计算机化的围产期数据库的持续增强以及作为MFMU作为MFMU的一部分而对协作研究的卓越承诺。