Bridging the Science-to-Service Gap in Aging Care: Prevention, Optimization and Living Well with Persistent or Serious Illnesses

缩小老年护理中科学与服务的差距：持续或严重疾病的预防、优化和健康生活

• 批准号: 10638577
• 负责人: Christine S Ritchie
• 金额: $ 17.4万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10638577
• 关键词: Aging; Caring; Prevention; Science; service gap

PROJECT SUMMARY: Bridging the Science-to-Service Gap in Aging Care (BRIDGE THE GAP): Prevention, Optimization and Living Well with Persistent or Serious Illnesses The proposed T32 postdoctoral fellowship will address the pressing need for strengthening and diversifying the pipeline for well-trained clinician investigators positioned to advance the field of aging research through the development, testing, and implementation of clinical and behavioral preventive interventions (CBPIs) across the spectrum from health to illness across all care settings (e.g., hospital, nursing homes) and in the community for individuals and their informal caregivers. Despite advances in medical, social and behavioral sciences, a widely acknowledged science-to-service gap remains such that most interventions are rarely implemented in the routine care of older adults in clinical or community settings. This gap is particularly apparent in the care of those with Alzheimer’s Disease and related dementias (ADRD), where there is a dearth of evidence-based approaches to support persons living with dementia (PLWD) and their caregivers across the disease trajectory. A key reason for this “implementation cliff” is the lack of rigorous and comprehensive training in all stages of the NIH model for new clinical investigators that enter the field of aging. Further, to date, very little research has been focused on prevention of age-related negative consequences. We are well positioned to address this important gap because we have access to both an exceptionally talented pool of interdisciplinary trainees (PhD and MD) and an unparalleled network of interdisciplinary, NIH funded faculty mentors and investigators with complementary expertise in CBPIs in primary prevention (e.g. treating ADRD risk factors to prevent onset), secondary prevention (e.g., prevention of emotional distress in ADRD), and tertiary prevention (e.g., increasing quality of life in ADRD). Two new trainees who have recently completed their clinical training will enter the program each year and will receive a maximum of three years of support (maximum 6 trainees at one time). Trainees will receive interdisciplinary mentorship across 1) the Department of Internal Medicine Mongan Institute (including the Center for Aging and Serious Illness) 2) the Department of Psychiatry (including the Center for Health Outcomes and Interdisciplinary Research) and 3) the Department of Neurology (including the Massachusetts ADRD Research Center). Trainees will receive specialized didactic training that covers methods across the NIH stage model, trial design and community engaged research across primary, secondary and tertiary prevention, biostatistics, clinical trial management, scientific writing, health disparities and social determinants of health, leadership skills and career planning, in preparation for career development awards or other independent applications to be submitted by the end of the fellowship period. Trainees will develop mentored clinical research projects that use the NIH stage model and will receive experiential training through their mentors’ NIH funded clinical trials. Our trainees will graduate with a deep understanding of the NIH stage model, skills to develop and implement scalable and equitable preventive interventions in all care settings, and the research tools necessary to advance the science of aging and improve care for our growing older adult population.

项目摘要：弥合老年护理中的科学与服务差距（BRIDGE THE GAP）：预防、 患有持续性或严重疾病时的优化和良好生活 拟议的 T32 博士后奖学金将解决加强和多样化管道的迫切需要 训练有素的临床研究人员致力于通过开发、测试和 实施从健康到疾病的临床和行为预防干预措施（CBPI） 所有护理场所（例如医院、疗养院）和社区中的个人及其非正式护理人员。 尽管医学、社会和行为科学取得了进步，但广泛承认的科学与服务之间的差距仍然如此，以至于大多数人 在临床或社区环境中，很少在老年人的常规护理中实施干预措施。 在对阿尔茨海默病和相关痴呆症 (ADRD) 患者的护理中尤其明显，因为这些地方缺乏 为痴呆症患者 (PLWD) 及其护理人员提供跨疾病支持的循证方法 造成这种“执行悬崖”的一个关键原因是各阶段缺乏严格、全面的训练。 此外，迄今为止，针对进入衰老领域的新临床研究人员的 NIH 模型还很少。 我们有能力解决这一重要差距，因为我们致力于预防与年龄相关的负面后果。 我们拥有一批才华横溢的跨学科实习生（博士和医学博士）和无与伦比的人才 由 NIH 资助的跨学科网络导师和研究人员组成，他们在 CBPI 方面具有互补的专业知识 一级预防（例如治疗ADRD危险因素以预防发病），二级预防（例如预防情绪障碍） ADRD 的困扰）和三级预防（例如，提高 ADRD 的生活质量）。 完成临床培训后每年都会进入该计划并将获得最多三年的支持 （一次最多 6 名学员） 学员将接受 1) 内部部门的跨学科指导。 医学蒙根研究所（包括老龄化和严重疾病中心）2）精神病学系（包括 健康结果和跨学科研究中心）和 3）神经病学系（包括 马萨诸塞州 ADRD 研究中心）。学员将接受涵盖整个方法的专门教学培训。 NIH 阶段模型、试验设计和社区参与的一级、二级和三级预防研究， 生物统计学、临床试验管理、科学写作、健康差异和健康的社会决定因素、领导力 技能和职业规划，为职业发展奖或其他要提交的独立申请做准备 在奖学金期结束时，学员将开发使用 NIH 阶段模型的指导临床研究项目。 并将通过其导师的 NIH 资助的临床试验接受体验式培训。 对 NIH 阶段模型的深入了解，以及开发和实施可扩展且公平的预防干预措施的技能 在所有护理环境中，以及推进衰老科学和改善对老年人的护理所必需的研究工具 成年人口。

项目成果

Perceived discrimination and problematic opioid use among Black individuals with chronic musculoskeletal pain.

患有慢性肌肉骨骼疼痛的黑人中存在歧视和有问题的阿片类药物使用。

• 发表时间: 2023-12-07
• 作者: Doorley, James D;Hooker, Julia E;Briskin, Ellie A;Bakhshaie, Jafar;Vranceanu, Ana
• 通讯作者: Vranceanu, Ana

Impact of Preexisting Depression and Anxiety on Hospital Readmission and Long-Term Survival After Cardiac Arrest.

先前存在的抑郁和焦虑对心脏骤停后再入院和长期生存的影响。

• 发表时间: 2023-12-10
• 影响因子: 3.1
• 作者: Coppler, Patrick J;Brown, McKenzie;Moschenross, Darcy M;Gopalan, Priya R;Presciutti, Alexander M;Doshi, Ankur A;Sawyer, Kelly N;Frisch, Adam;Callaway, Clifton W;Elmer, Jonathan;University of Pittsburgh Post
• 通讯作者: University of Pittsburgh Post

The impact of a virtual mind-body program on resilience factors among international English-speaking adults with neurofibromatoses: secondary analysis of a randomized clinical trial.

虚拟身心计划对患有神经纤维瘤的国际英语成人的复原力因素的影响：随机临床试验的二次分析。

• 发表时间: 2023-07
• 影响因子: 3.9
• 作者: Presciutti, Alexander M;Lester, Ethan G;Woodworth, Emily C;Greenberg, Jonathan;Bakhshaie, Jafar;Hooker, Julia E;McDermott, Katherine A;Vranceanu, Ana
• 通讯作者: Vranceanu, Ana