Functions of the Cortical Amygdala in social behavior

皮质杏仁核在社会行为中的功能

• 批准号: 10641270
• 负责人: Antonio V Aubry
• 金额: $ 13.69万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641270
• 关键词: Adaptive Behaviors; Affect; Aggressive behavior; Amygdaloid structure; Anger; Animals; Anogenital region; Axon; Behavior; Behavior Control; Behavioral; Brain region; Cells; Child Rearing; Complex; Corpus striatum structure; Cues; Data; ESR1 gene; Economic Burden; Ensure; Exhibits; Face; Female; Fiber; Fire - disasters; Food; Globus Pallidus; Home; Human; Hypothalamic structure; Image; Impairment; Individual; Individual Differences; Investigation; Lateral; Learning; Link; Mediating; Mental disorders; Modeling; Motivation; Mouse Strains; Mus; Odors; Partner in relationship; Pathologic; Perception; Perforation; Phase; Photometry; Play; Population; Process; Research; Research Personnel; Resources; Risk; Rodent; Role; Self Administration; Sensory; Signal Transduction; Slice; Smell Perception; Social Behavior; Social Environment; Social Hierarchy; Social Perception; Social Protection; Societies; Stimulus; Structure; System; Testing; Training; Ventral Striatum; Vision; Visual System; Whole-Cell Recordings; Work; behavioral response; cell type; diencephalon; in vivo; male; motivational processes; neuromechanism; nonhuman primate; olfactory bulb; olfactory stimulus; optogenetics; prevent; programs; response; sensory input; social

Project Summary Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In most cases, aggression is a necessary, adaptive component of social behavior. In humans, however, some forms of aggression are considered pathological when they threaten lives, increase the risk of psychiatric impairment in victims, and incur economic burdens on society. Considerable evidence indicates that aggression is associated with aberrant facial perception in humans. Physically aggressive individuals have a tendency to identify ambiguous faces as threatening or angry. This suggests that these individuals have a perceptual bias which impairs the ability of the individual to interpret the level of threat correctly. There is ample evidence in human and non-human primates that the amygdala plays a key role in social perception. Studies with human and non-human primates examining the amygdala's role in social perception have focused on the lateral and basolateral amygdala given their extensive connections with the visual system and because they are a highly dependent on vision. Conversely, rodents are more reliant on olfaction, and thus, we need a deeper understanding of amygdala interactions with olfactory structures during social encounters. The posterior cortical amygdala (COAp) is one such region which receives input from olfactory structures. Our preliminary data suggest that activation of ESR-1 cells in the COAp are necessary for aggressive behavior to occur in males but not females. Furthermore, these cells show an increase in activity during attack behavior in males. In addition to the expected input from the main olfactory bulb, we discovered that this cell population also receives input from the ventral striatopallidal system, which is involved in motivational processes. For the K99 phase of this proposal, I will test the hypothesis that the ventral striatopallidal system affects the motivation to attack by modulating preparatory activity in the COAp. Over the R00 phase, I will build a research program to test the hypothesis that the COAp mediates state-dependent responses to social olfactory stimuli. In order to induce an “aggressive state” in mice we will use the social instigation model. The results from this proposal will increase the field's understanding of how non-sensory variables affect what are traditionally known as sensory regions. In addition, the proposed training will allow me to develop a future research program geared towards identifying mechanisms underlying the effects of altered behavioral states on perceptual processes.

项目概要 攻击是一种进化上保守的行为，它控制社会等级并保护有价值的东西 在大多数情况下，攻击性是一个必要的、适应性的组成部分。 然而，在人类中，某些形式的攻击行为在发生时被认为是病态的。 生命受到威胁，增加受害者精神障碍的风险，并给社会带来经济负担。 大量证据表明，攻击性与人类异常的面部感知有关。 具有攻击性的人倾向于将模糊的面孔视为威胁或愤怒。 表明这些人存在知觉偏见，损害了个人解释事物的能力 在人类和非人类灵长类动物中，有充分的证据表明杏仁核发挥着重要作用。 对人类和非人类灵长类动物的研究检查了杏仁核在社会感知中的作用。 鉴于外侧杏仁核和基底外侧杏仁核与人的广泛联系，社会认知集中在它们 视觉系统，因为它们高度依赖于视觉。 嗅觉，因此，我们需要更深入地了解杏仁核与嗅觉结构的相互作用 后皮质杏仁核（COAp）就是这样一个区域，它接收来自社交的输入。 我们的初步数据表明 COAp 中的 ESR-1 细胞的激活对于嗅觉结构是必要的。 攻击性行为发生在男性而非女性身上。此外，这些细胞表现出活性增加。 在男性的攻击行为期间，除了来自主嗅球的预期输入之外，我们还发现。 该细胞群还接收来自腹侧纹状体苍白球系统的输入，该系统参与 对于该提案的 K99 阶段，我将测试腹侧的假设。 纹状体苍白球系统通过调节 COAp 的准备活动来影响攻击动机。 R00阶段，我将建立一个研究计划来检验COAp介导状态依赖性的假设 对社会嗅觉刺激的反应为了诱导小鼠的“攻击状态”，我们将使用社会嗅觉刺激。 该提案的结果将增加该领域对非感官性的理解。 变量会影响传统上所谓的感觉区域。此外，拟议的培训将允许我。 制定一个未来的研究计划，旨在确定影响的潜在机制 知觉过程的行为状态。