Enabling clinical tissue microstructure imaging as a diagnostic tool in wide-bore 3T MRI

将临床组织微观结构成像作为大口径 3T MRI 的诊断工具

基本信息

批准号：
10640750
负责人：
Oguz Akin
金额：
$ 0.32万
依托单位：
GENERAL ELECTRIC GLOBAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2023-10-02
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10640750
关键词：
Abnormal Cell Address Adopted Adoption Appearance Architecture Biomedical Engineering Biopsy Biopsy Specimen Blood Vessels Brain Breast Cancer Etiology Cancer Prognosis Cardiac Cause of Death Cessation of life Charge Clinic Clinical Complex Data Detection Diabetes Mellitus Diagnosis Diffusion Diffusion Magnetic Resonance Imaging Disease Electronics Elements Epithelium Frequencies Gleason Grade for Prostate Cancer Glioma Goals Hemorrhage Histopathology Hospitals Human Image Imaging Device Indolent Industry Infection Infrastructure Lesion Magnetic Resonance Imaging Malignant Neoplasms Malignant neoplasm of prostate Measurement Measures Memorial Sloan-Kettering Cancer Center Methods Microscopic Modeling Modification Musculoskeletal Output Pain Pathway interactions Patient risk Patients Pattern Performance Pilot Projects Procedures Prostate Prostatectomy Recommendation Relaxation Research Sampling Sampling Errors Semiconductors Sensitivity and Specificity Services Signal Transduction Silicon Specificity Structure System Techniques Technology Testing Time Tissue Sample Tissues Universities Work cancer diagnosis clinical application clinical diagnosis clinical diagnostics clinical efficacy clinically significant cost design diagnostic tool digital imaging modality improved men multidisciplinary neuroimaging novel oscillating gradient spin echo pre-clinical prostate biopsy prototype silicon carbide soft tissue standard of care success tool tumor tumor heterogeneity ultrasound

项目摘要

PROJECT SUMMARY/ABSTRACT Definitive characterization of cytoarchitecture and its alternation is key to clinical diagnosis and patient management in disease, including cancer. Current standard-of-care of such microstructure characterization is based primarily on histopathological assessment via biopsy sampling of suspected lesions. However, invasive biopsy procedures carry burdens of procedure complexity, sampling errors, and complications. Thus, it is desirable to have a non-invasive, high-sensitivity, high-specificity imaging tool that accurately assesses tumor microstructures that are comparable to that obtained from biopsy/histopathology. This will have the clinically significant result of reducing unnecessary biopsies at the minimum, and perhaps reduce the overall number of biopsy procedures and repeat biopsies. Furthermore, this will significantly improve the precision of biopsy to sample clinically significant cancers and regions most relevant to cancer prognosis. We propose to apply advanced diffusion MRI (dMRI), including novel oscillating gradient spin echo (OGSE) diffusion encoding, for tumor microstructure imaging and the pilot application will be to improve characterization of the epithelium, stroma, and lumen volume fractions which are highly correlated to prostate cancer grades. OGSE dMRI has been attempted in clinical whole-body MRI but the technique has had only modest success due to the limited gradient performance of whole-body MRI scanners. The gradient amplitude and slew rate of existing clinical whole-body 3.0T MRI scanners are often constrained by peak power of the gradient driver. Many clinical 70- cm wide-bore MRI systems operate at 1 MVA peak power, while some high-end systems increase the peak power to 2-2.7 MVA. However, the 2-3X higher peak power substantially increases the overall cost of MRI systems and requires major increases to the hospital's electrical service and cooling infrastructure to accommodate increased electrical power and thermal loads. Consequently, such upgrades become cost prohibitive and are impractical for wide adoption. Our technical solution is to build a new 4 MVA silicon carbide (SiC) semiconductor gradient driver which replaces a conventional silicon 1 MVA or 2 MVA gradient driver in clinical 3.0T wide-bore MRI scanners without requiring any changes to facility infrastructure. We have assembled a diverse, multi-disciplinary team from GE Research, Memorial Sloan Kettering Cancer Center, and Stanford University to develop MRI tools and methods to address clinical needs of non-invasive tumor microstructure imaging to solve clinically significant problems in cancer. We will demonstrate tumor microstructure imaging enabled by higher gradient amplitude and slew rate can provide clinical diagnostic information on tumor characterization comparable to that obtained from biopsy and move closer to the goal of reducing unnecessary biopsies. We will demonstrate the clinical significance in prostate cancer, as it is the second leading cause of death in men. It is applicable to other cancers and a broad range of clinical applications where non-invasive tumor microstructure characterization will significantly improve patient management.

项目概要/摘要细胞结构的明确表征及其变化对于临床诊断和患者治疗至关重要疾病管理，包括癌症。目前这种微观结构表征的护理标准是主要基于通过可疑病变的活检取样进行的组织病理学评估。然而，侵入性活检程序带来程序复杂性、采样误差和并发症的负担。因此，它是迫切需要一种非侵入性、高灵敏度、高特异性的成像工具来准确评估肿瘤与活检/组织病理学获得的微观结构相当。这将在临床上至少减少不必要的活检的显着结果，并且可能减少活检的总数活检程序和重复活检。此外，这将显着提高活检的精确度对具有临床意义的癌症和与癌症预后最相关的区域进行采样。我们建议申请先进的扩散 MRI (dMRI)，包括新颖的振荡梯度自旋回波 (OGSE) 扩散编码，用于肿瘤微结构成像和试点应用将改善上皮的特征，基质和管腔体积分数与前列腺癌分级高度相关。 OGSE dMRI 有临床全身 MRI 已被尝试过，但由于有限的条件，该技术仅取得了一定的成功。全身 MRI 扫描仪的梯度性能。现有临床的梯度幅值和转换率全身 3.0T MRI 扫描仪通常受到梯度驱动器峰值功率的限制。许多临床70- cm 宽口径 MRI 系统以 1 MVA 峰值功率运行，而一些高端系统会提高峰值功率功率为 2-2.7 MVA。然而，峰值功率提高 2-3 倍大大增加了 MRI 的总体成本系统，并需要大幅增加医院的电力服务和冷却基础设施，以适应增加的电力和热负荷。因此，此类升级成为成本对于广泛采用来说是令人望而却步且不切实际的。我们的技术解决方案是建造一个新的 4 MVA 硅片碳化硅 (SiC) 半导体梯度驱动器，取代传统硅 1 MVA 或 2 MVA 梯度临床 3.0T 大口径 MRI 扫描仪的驱动程序，无需对设施基础设施进行任何更改。我们从 GE 研究中心、纪念斯隆凯特琳癌症中心组建了一支多元化、多学科的团队，与斯坦福大学合作开发 MRI 工具和方法，以满足非侵入性肿瘤的临床需求微观结构成像解决癌症的临床重大问题。我们将展示肿瘤通过更高的梯度幅度和转换速率实现的微结构成像可以提供临床诊断有关肿瘤特征的信息与活检获得的信息相当，并且更接近目标减少不必要的活检。我们将证明前列腺癌的临床意义，因为它是男性第二大死因。它适用于其他癌症和广泛的临床应用非侵入性肿瘤微观结构表征将显着改善患者管理。