Seasonality of Suicide and Airborne Allergens

自杀和空气过敏原的季节性

基本信息

批准号：
7538336
负责人：
TEODOR T POSTOLACHE
金额：
$ 28.68万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-01 至 2011-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7538336
关键词：
Address Affect Allergens Allergic Ambrosia Animals Antidepressive Agents Autopsy Clinical Clinical Research Country Data Denmark Depression and Suicide Diagnosis Disease Environment Epidemiology Exposure to Family Family history of Frequencies Gender Goals High Prevalence Hypersensitivity Individual Inflammation Mediators Inflammatory Laboratories Life Linear Models Link Logistic Regressions Marshal Mediating Methodology Modeling Mood Disorders Moods National Health and Nutrition Examination Survey Natural experiment Participant Pharmaceutical Preparations Pollen Process Publications Recording of previous events Relative (related person)Relative Risks Reporting Research Personnel Risk Rural Sampling Seasonal Affective Disorder Skin Socioeconomic Factors Suicide Suicide attempt Suicide prevention Taxon Testing Time Trees Woman Work accomplished suicide airborne allergen base brain tissue case control cytokine depression design falls improved low socioeconomic status novel programs socioeconomics suicidal risk suicide rate tree pollen

项目摘要

DESCRIPTION (provided by applicant): Introduction: This is an extensive revision of our prior application which makes better use of the opportunities of the Danish longitudinal registers and gives us a robust power for testing our highly novel hypothesis that aeroallergens and allergy are associated with suicide. Issues of temporal and topographic clustering have been addressed, the focus of the design has been tightened and more details are given regarding the analysis. Background: Seasonal peaks of suicide in spring have been consistently reported but the origin is poorly understood. Benefiting from a natural experiment (the abrupt rise of tree-pollen in spring), and considering the high prevalence of allergic sensitization (40-50%), we proposed that the massive release of tree-pollen in spring, via mediators of inflammation, elevates the relative risk for suicide, by affecting individuals with vulnerability for allergies, depression, and suicide. The aims of the study are 1) to confirm the relationship between allergen peaks and suicide peaks (using an ecologic approach and a generalized linear model allowing us to address geographic and temporal clustering), 2) to estimate a predictive association between allergy and suicide, with adjustment for and interaction with variables previously described to be related to suicide, such as diagnosis of mood disorders, prior suicide attempts, and other demographic /socioeconomic variables related to suicide risk, using a nested case control design and conditional logistic regression models , and 3) to estimate the predictive association between spring allergy, and spring suicide during peak tree-pollen periods in interaction with history of mood disorders using conditional logistic regression models. Secondary aims are to analyze specifically the predictive association between allergy and mood disorders and suicidal attempts in individuals and families, to evaluate interactions with demographic and socioeconomic factors, and to estimate protective versus risk elevating effects of (anti-allergy and psychotropic) medications. Implications: The study is poised to identify a potential novel vulnerability for suicide, i.e., allergic sensitization, and a potential novel trigger, aeroallergen exposure, and, in the process, to replicate the previously reported gender-specific relationship between allergy and mood disorders, in individuals and families. Confirming that allergens and allergy are related to suicide epidemiologically, in conjunction with clinical research and laboratory work, is expected to improve prediction and prevention of suicide.

描述（由申请人提供）：简介：这是对我们先前申请的广泛修订，它更好地利用了丹麦纵向记录的机会，并为我们提供了强大的力量来测试我们的高度新颖的假设，即空气过敏原和过敏与自杀有关。时间和地形聚类问题已经得到解决，设计的重点已经加强，并给出了有关分析的更多细节。背景：春季自杀高峰的报道一直存在，但其起源却知之甚少。受益于自然实验（春季树木花粉的突然增加），并考虑到过敏性致敏的高患病率（40-50％），我们提出春季树木花粉的大量释放，通过炎症介质，通过影响易过敏、抑郁和自杀的个体，增加自杀的相对风险。该研究的目的是 1) 确认过敏原峰值和自杀峰值之间的关系（使用生态学方法和广义线性模型，使我们能够解决地理和时间聚类问题），2) 估计过敏和自杀之间的预测关联，使用嵌套病例对照设计和条件逻辑回归模型，对先前描述的与自杀相关的变量进行调整和相互作用，例如情绪障碍的诊断、既往自杀企图以及与自杀风险相关的其他人口/社会经济变量，以及3）使用条件逻辑回归模型估计春季过敏和树花粉高峰期春季自杀与情绪障碍史之间的预测关联。次要目标是专门分析过敏和情绪障碍与个人和家庭自杀企图之间的预测关联，评估与人口和社会经济因素的相互作用，并评估（抗过敏和精神药物）药物的保护作用与风险升高作用。意义：该研究旨在确定一种潜在的新的自杀脆弱性，即过敏性致敏，以及一种潜在的新的触发因素，即空气过敏原暴露，并在此过程中复制之前报道的过敏和情绪障碍之间的性别特异性关系，在个人和家庭中。从流行病学角度确认过敏原和过敏与自杀相关，结合临床研究和实验室工作，有望改善自杀的预测和预防。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Pollen counts and suicide rates. Association not replicated.

DOI：
10.1111/j.1600-0447.2011.01813.x
发表时间：
2012-02
期刊：
Acta psychiatrica Scandinavica
影响因子：
6.7
作者：
Woo JM;Gibbons RD;Rogers CA;Qin P;Kim JB;Roberts DW;Noh ES;Mann JJ;Postolache TT
通讯作者：
Postolache TT

Seasonal spring peaks of suicide in victims with and without prior history of hospitalization for mood disorders.

DOI：
10.1016/j.jad.2009.05.015
发表时间：
2010-02
期刊：
JOURNAL OF AFFECTIVE DISORDERS
影响因子：
6.6
作者：
Postolache, Teodor T.;Mortensen, Preben B.;Tonelli, Leonardo H.;Jiao, Xiaolong;Frangakis, Constantin;Soriano, Joseph J.;Qin, Ping
通讯作者：
Qin, Ping

Asthma and Mood Disorders.

DOI：
发表时间：
2008
期刊：
International journal of child health and human development : IJCHD
影响因子：
0
作者：
A. Kewalramani;M. Bollinger;T. Postolache,
通讯作者：
A. Kewalramani;M. Bollinger;T. Postolache,

Allergen Specific IgE, Number and Timing of Past Suicide Attempts, and Instability in Patients with Recurrent Mood Disorders.

过敏原特异性 IgE、过去自杀企图的次数和时间，以及复发性情绪障碍患者的不稳定。

DOI：
发表时间：
2008
期刊：
International journal of child health and human development : IJCHD
影响因子：
0
作者：
Postolache,TeodorT;Roberts,DarrylW;Langenberg,Patricia;Muravitskaja,Olesja;Stiller,JohnW;Hamilton,RobertG;Tonelli,LeonardoH
通讯作者：
Tonelli,LeonardoH

Allergy is associated with suicide completion with a possible mediating role of mood disorder - a population-based study.