THE WASHU TARGET ENVIRONMENTAL EPIGENOMICS DATA COORDINATION CENTER

Washu Target 环境表观基因组数据协调中心

基本信息

批准号：
10450248
负责人：
Ting Wang
金额：
$ 51万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10450248
关键词：
Address Adopted Biological Assay Books Cells Chemicals Collaborations Communication Communities Complex Computer Analysis Computer software Controlled Vocabulary Data Data Analyses Data Coordinating Center Data Set Databases Development Disease susceptibility Documentation Dose Education and Outreach Educational workshop Ensure Environment Environmental Exposure Epigenetic Process Fostering Genes Genetic Transcription Genetic Variation Genomics Goals Human Image Laboratories Maps Metadata Modeling Mus Online Systems Paper Participant Pathway interactions Periodicity Phase Process Production Progress Reports Provider Public Health Publications Quality Control Research Rodent Role Software Engineering Speed Structure System Technology Testing Time Tissues Toxicant exposure Training Vision Visualization Work Writing analysis pipeline biological research cell type complex data computerized tools data format data mining data portal data resource data standards data tools data visualization distributed data epigenome epigenomics formycin triphosphate genome browser genomic data large datasets meetings member metadata standards next generation sequencing novel programs public health relevance quality assurance repository response sequencing platform service organization symposium tool verification and validation webinar

项目摘要

DESCRIPTION (provided by applicant): The goals of the WashU TaRGET Environmental Epigenomics Data Coordination Center (TaRGET T2C DCC) component to the TaRGET Consortium are to collect, store, curate, and display all data, metadata, and analysis tools generated by the TaRGET. The DCC will also assist in the development and dissemination of metadata and standards to be adopted by the community at large, approaches for integrative analysis of a wide-range of data types, and visualization and analysis tools to facilitate access and understanding of complex datasets to non-expert users. Ultimately, the TaRGET Consortium will produce tools, analysis, models, and data that form the reference maps of the environmental exposure related epigenomes of different cells and tissues, and we will develop the DCC into a substantial service organization allowing scientific research to take full advantage of the TaRGET reference maps. To support the TaRGET Consortium, we will establish databases with an application framework to facilitate complex data loading including detailed experimental descriptions and metadata; we will define and establish pipelines that connect all Consortium members to the data, and create avenues of access that distribute the data to the greater biological research community; we will establish metadata requirements, controlled vocabularies, standardized data formats, and quality control metrics for all TaRGET data; we will bring together laboratories that generate complex data types via experimental assays with laboratories that integrate these data using computational tools to define the epigenomic programs in the context of environmental exposure. Through the creation of structures data flow pipelines for the verification and validation of all data, and providing processes for the documentation of metadata, the DCC will enhance the TaRGET data production. The DCC will also coordinate integrative data analysis by creating and adapting analysis pipelines, and by developing advanced Genome Browser functions for the visual integration of TaRGET data. In addition, we will create TaRGET Data Portal that will be the primary entry point to the wealth of experimental data as well as computational analyses. The Portal will integrate these data resources and make them available via enhanced search and browsing capabilities. Finally, the DCC will provide documentation, training, and outreach via many media including written documentation, video tutorials, online books, webinars, and meeting workshops and presentations.

描述（由申请人提供）：TaRGET 联盟的 WashU Target 环境表观基因组学数据协调中心 (TaRGET T2C DCC) 的目标是收集、存储、管理和显示 TaRGET 生成的所有数据、元数据和分析工具DCC 还将协助开发和传播供整个社区采用的元数据和标准，以及对广泛领域进行综合分析的方法。最终，TaRGET 联盟将提供各种数据类型、可视化和分析工具，以方便非专家用户访问和理解复杂的数据集，从而形成不同环境暴露相关表观基因组的参考图。细胞和组织，我们将把 DCC 发展成为一个实质性的服务组织，使科学研究能够充分利用 TaRGET 参考图谱。为了支持 TaRGET 联盟，我们将建立具有应用程序框架的数据库，以促进复杂的数据加载，包括详细的实验。描述和元数据；我们将定义和建立将所有联盟成员连接到数据的管道，并创建将数据分发给更大的生物研究界的访问途径；我们将建立元数据要求、受控词汇、标准化数据格式和质量所有 TaRGET 数据的控制指标；我们将把通过实验分析生成复杂数据类型的实验室与使用计算工具整合这些数据的实验室结合起来，通过创建环境暴露的表观基因组程序来定义表观基因组程序。构建数据流管道以验证和验证所有数据，并提供元数据记录流程，DCC 还将通过创建和调整分析管道以及开发先进的分析管道来增强协调 TaRGET 数据生产。用于 TaRGET 数据可视化集成的基因组浏览器功能此外，我们将创建 TaRGET 数据门户，该门户将成为丰富的实验数据以及计算分析的主要入口点。最后，DCC 将通过多种媒体提供文档、培训和宣传，包括书面文档、视频教程、在线书籍、网络研讨会以及会议研讨会和演示。