Epidemiology, impact, and experience of acne in transgender persons

跨性别者痤疮的流行病学、影响和经历

• 批准号: 10458763
• 负责人: Howa Yeung
• 金额: $ 15.78万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-20 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458763
• 关键词: Accounting; Acne; Address; Adult; Adverse effects; Age; Androgens; Antiandrogen Therapy; Area; Arthritis; Asthma; Benefits and Risks; Birth; Carcinoma; Caring; Characteristics; Chronic Disease; Clinical; Clinical Practice Guideline; Clinical Trials; Collection; Cutaneous; Data; Data Collection; Development; Diabetes Mellitus; Diagnosis; Epidemiology; Feeling suicidal; Feminization; Funding; Future; Gender; Gender Identity; Goals; Health; Health Disparities Research; Health Status; Healthcare Systems; High Prevalence; Hormonal; Hormone use; Hormones; Impaired health; Impairment; Incidence; Individual; Intervention; Interview; Knowledge; Measures; Mediating; Mediator of activation protein; Mental Depression; Mental Health; Mental disorders; Mentors; Mentorship; Methods; Modeling; Multicenter Studies; National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; Natural History; Oral Contraceptives; Outcome; Outcomes Research; Pathogenesis; Patient Recruitments; Patients; Persons; Population; Prevalence; Prospective Studies; Prospective cohort study; Protocols documentation; Psoriasis; Quality of life; Race; Research; Research Methodology; Research Personnel; Research Technics; Research Training; Retrospective Studies; Severities; Sexual Health; Sexual and Gender Minorities; Site; Skin; Surveys; Techniques; Testosterone; Training; Well in self; Woman; base; career; clinical practice; cohort; community engaged research; comorbidity; cost; design; disability burden; disparity reduction; experience; future implementation; gender dysphoria; gender minority group; gender minority health disparity; health care disparity; health care settings; health disparity; health disparity populations; health related quality of life; high risk; hormone therapy; improved; interest; keratinocyte; melanoma; men; minority disparity; minority health; minority stress; multidisciplinary; patient oriented; pilot test; recruit; self esteem; sex; sexual disparity; skin disorder; social; theories; transfeminine; transgender; transmasculine

PROJECT SUMMARY / ABSTRACT The overall objective of this K23 proposal is to support new research training and experience crucial for the candidate, Howa Yeung, MD MSc, to become an independent, patient-oriented investigator addressing sexual and gender minority disparities in skin diseases – such as acne in transgender persons. Acne significantly impairs health-related quality of life and is associated with depression, low self-esteem, and suicidal ideation. Little is known about the interplay of endogenous and exogenous hormones on acne incidence, severity, impact, treatment, and experience. Our prior studies noted higher acne prevalence associated with hormone therapy and identified specific barriers for severe acne treatment in transgender persons. This proposal aims to examine the epidemiology, impact, and experience of acne in the context of hormone therapy in transgender persons – a health disparity population with significant knowledge gaps in skin health. The epidemiology of acne will be examined using data from the existing large-scale, validated, multicenter Study of Transition, Outcomes and Gender (STRONG). Factors that mediate differences in acne experience, treatment, and research participation will be newly elicited using mixed methods. Development and pilot testing of a recruitment protocol and collection of preliminary data on acne outcomes and mental health comorbidity will help initiate a prospective cohort study of acne in transgender persons receiving hormone therapy. To achieve these aims, the candidate will require additional training through a combination of formal didactics, practical research experience, and expert multidisciplinary mentorship. The candidate will build expertise in sexual and gender minority health and health disparities research, patient-oriented outcomes research in acne, mixed- methods research techniques, as well as experience in community-engaged research and patient recruitment. The candidate’s mentored training and research plans will enable him to launch a successful career as an independent patient-oriented investigator addressing sexual and gender minority disparities in skin diseases – such as acne in transgender persons. Key results will inform new acne and gender-affirming hormone treatment paradigms and the design and implementation of future interventions, aimed to reduce the identified acne disparities, optimize acne clinical outcomes, and to improve patient-centeredness of hormone therapy in transgender persons.

项目概要/摘要 K23 提案的总体目标是支持新的研究培训和经验，这对于 候选人 Howa Yeung，医学博士、理学硕士，将成为一名独立的、以患者为中心的调查员，解决性问题 以及皮肤病方面的性别少数差异——例如跨性别者的痤疮。 损害与健康相关的生活质量，并与抑郁、低自尊和自杀意念有关。 人们对内源性和外源性激素对痤疮发生率、严重程度的相互作用知之甚少。 我们之前的研究指出，痤疮患病率较高与激素有关。 治疗并确定了跨性别者严重痤疮治疗的具体障碍。 研究跨性别者激素治疗背景下痤疮的流行病学、影响和经验 人群——在皮肤健康方面存在显着知识差距的健康差异人群。 将使用现有的大规模、经过验证的、多中心转变研究的数据来检查痤疮， 结果和性别（强）。影响痤疮经历、治疗和治疗差异的因素。 将使用混合方法来新激发研究参与。 招募协议和收集有关痤疮结果和心理健康合并症的初步数据将 帮助启动一项针对接受激素治疗的跨性别者痤疮的前瞻性队列研究。 为了实现这些目标，候选人将需要通过正式教学、实践教学相结合的额外培训 研究经验和多学科专家指导候选人将积累性和性方面的专业知识。 性别少数群体健康和健康差异研究、以患者为导向的痤疮结果研究、混合- 方法、研究技术以及社区参与研究和患者招募的经验。 候选人的指导培训和研究计划将使他能够作为一名成功的职业生涯 以患者为中心的独立调查员解决皮肤病中的性和性别少数差异 - 例如跨性别者的痤疮关键结果将告知新的痤疮和性别肯定激素。 治疗范式以及未来干预措施的设计和实施，旨在减少已确定的 痤疮差异，优化痤疮临床结果，并提高激素治疗的以患者为中心的程度 跨性别者。