Renally clearable ytterbium nanoparticle contrast agents for spectral photon counting computed tomography

用于光谱光子计数计算机断层扫描的肾可清除镱纳米粒子造影剂

• 批准号: 10459234
• 负责人: David Peter Cormode
• 金额: $ 24.38万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10459234
• 关键词: Allergic Reaction; Angiography; Area; Arterial Fatty Streak; Atherosclerosis; Biodistribution; Biological; Blood Vessels; Calcium; Cardiovascular Diagnostic Techniques; Cardiovascular Diseases; Cardiovascular system; Clinical; Clinical Trials; Computed Tomography Scanners; Contrast Media; Coronary artery; Data Set; Detection; Diagnosis; Disease; Dose; Drug Kinetics; Elements; Excretory function; Formulation; Funding; Generations; Gold; Heart; Image; Imaging Techniques; In Vitro; Industrialization; Iodine; Kidney; Kidney Diseases; Kidney Failure; Lead; Low Dose Radiation; Measurement; Measures; Modeling; Modern Medicine; Monitor; Morphologic artifacts; Movement; Myocardial Infarction; Noise; Oryctolagus cuniculus; Patient risk; Patients; Performance; Photons; Population; Price; Published Comment; Renal function; Resolution; Roentgen Rays; Safety; Scanning; Solubility; Source; Stents; Sum; Techniques; Technology; Testing; Toxicology; United States National Institutes of Health; Vascular blood supply; Work; X-Ray Computed Tomography; Ytterbium; base; biomaterial compatibility; calcification; cardiovascular imaging; contrast enhanced computed tomography; cost effective; cytotoxicity; design; detector; imaging modality; improved; in vivo; mouse model; nanoparticle; novel; photon-counting detector; prototype; public health relevance; renal damage; small molecule; temporal measurement; tool

PROJECT SUMMARY Conventional CT imaging is very widely used in modern medicine, with 80 million scans performed per year in the USA. CT has important cardiovascular applications such as calcium scoring and coronary artery angiography. A new form of CT is emerging, which is known as spectral photon counting CT (SPCCT). This type of CT uses photon counting detectors as opposed to the energy integrating detectors used in conventional CT. SPCCT promises improvements over conventional CT such as lower radiation dose, higher spatial resolution and an improved ability to distinguish materials. The current iodine-based contrast agents used in CT imaging have several deficiencies such as very rapid clearance, lack of disease targeting, allergic reactions and potential for kidney damage, and are not ideal for SPCCT in particular since it is difficult to image iodine specifically. There is a need, therefore, to develop new contrast agents designed for SPCCT that can provide more accurate and enhanced diagnoses for cardiovascular disease. We have found that ytterbium is the most potent element for SPCCT contrast generation. We will develop novel, highly biocompatible ytterbium nanoparticle contrast agents for highly precise and low dose cardiovascular imaging with SPCCT.

项目概要 传统 CT 成像在现代医学中应用非常广泛，每年进行 8000 万次扫描 美国。 CT 具有重要的心血管应用，例如钙评分和冠状动脉 血管造影。一种新形式的 CT 正在出现，称为光谱光子计数 CT (SPCCT)。这 CT 类型使用光子计数探测器，而不是传统的能量积分探测器 CT。 SPCCT 有望比传统 CT 有所改进，例如辐射剂量更低、空间更高 分辨率和提高区分材料的能力。目前使用的碘基造影剂 CT成像存在一些缺陷，例如清除速度太快、缺乏疾病靶向性、过敏反应 和潜在的肾脏损伤，并且对于 SPCCT 来说并不理想，特别是因为它很难对碘进行成像 具体来说。因此，需要开发专为 SPCCT 设计的新型造影剂，以提供 更准确和增强的心血管疾病诊断。我们发现镱是最 SPCCT 对比生成的有效元素。我们将开发新型的、高度生物相容性的镱 纳米颗粒造影剂用于 SPCCT 高精度和低剂量心血管成像。

项目成果

Clinical Applications of Photon-counting CT: A Review of Pioneer Studies and a Glimpse into the Future.

光子计数 CT 的临床应用：先驱研究回顾和未来展望。

• 发表时间: 2023-10
• 影响因子: 19.7
• 作者: Douek, Philippe C;Boccalini, Sara;Oei, Edwin H G;Cormode, David P;Pourmorteza, Amir;Boussel, Loic;Si;Budde, Ricardo P J
• 通讯作者: Budde, Ricardo P J