Plug-And-Play Cochlear Electrode Array - Diversity Supplement.

即插即用耳蜗电极阵列 - 多样性补充。

• 批准号: 10328845
• 负责人: angelique johnson
• 金额: $ 1.29万
• 依托单位: MEMSTIM, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-15 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10328845
• 关键词: 3D Print; Address; Area; Biological; Categories; Cochlea; Cochlear Implants; Devices; Electrodes; Hand; Hearing Aids; Lasers; Length; Mechanics; Metals; Microfabrication; Miniaturization; Modulus; Music; Nature; Nerve Tissue; Otolaryngology; Output; Play; Printing; Resolution; Shapes; Silicones; Slide; Spinal Cord; Technology; Testing; Thick; biomaterial compatibility; cost; deep brain stimulator; design; elastomeric; falls; hearing impairment; improved; manufacturing process; millimeter; new technology; novel; parent grant; pre-clinical; speech recognition

Project Summary/Abstract Worldwide, approximately 466 million people suffer from disabling hearing loss. When conventional hearing aids provide no appreciable benefit, cochlear implants are a solution. Current cochlear implants, while beneficial in their use, are limited in their capabilities by hand-assembly of wire-bundled electrode arrays. Hand assembly is very costly, extremely labor-intensive, and inadequate in implementing new strategies in Otolaryngology for improving speech recognition and music appreciation. MEMStim LLC proposes a plug-and-play advanced-manufacturing solution that relies heavily on 3D printing. By printing conductive and nonconductive silicones, biocompatible pluggable arrays can be printed to any size, length, shape or thickness, from several microns to tens of millimeters. Most importantly, the integrated connectors plug readily onto stimulators by way of a novel micro-socket technology. The micro-sockets are compatible and slide right onto the feedthrough pins. The printer resolution can output pluggable connectors that are compatible with pin-to-pin pitches smaller than 100 μm (edge-to-edge), allowing for enhanced miniaturization. The 3D printed soft elastomeric arrays differ from wire-bundle cochlear implants in that they are less stiff and more susceptible to small changes in strain [add reference?]. They fall within a category of devices called “bioelectronics”, which have a Young’s Modulus (100 Pa-10MPa) in the range of most biological matter such as nerve tissue. Due to this difference, the candidate will strengthen our case to the FDA and cochlear manufacture’s themselves by conducting further electrical and mechanical tests to prove the functionality and durability under strain. The tests will also help us better understand the durability and reliability limits of our plug-and-play arrays for other neurostimulator application areas, such as spinal cord stimulators and deep brain stimulators.

项目概要/摘要 全球约有 4.66 亿人患有常规听力损失。 辅助设备没有提供明显的好处，人工耳蜗是一种解决方案，而目前的人工耳蜗是一种解决方案。 虽然它们的使用是有益的，但其功能受到手工组装线束电极阵列的限制。 组装成本非常高，劳动强度极大，并且不足以实施新的战略 耳鼻喉科可提高语音识别和音乐欣赏能力。 MEMStim LLC 提出了一种高度依赖 3D 打印的即插即用先进制造解决方案。 通过印刷导电和非导电有机硅，可以将生物相容性可插拔阵列印刷成任何尺寸， 长度、形状或厚度，从几微米到几十毫米，最重要的是集成度。 连接器通过新颖的微插座技术轻松插入刺激器。 兼容并向右滑到馈通引脚上，打印机分辨率可以输出可插拔连接器。 与小于 100 μm（边到边）的引脚到引脚间距兼容，从而可以增强 小型化。 3D 打印软弹性体阵列与线束人工耳蜗植入体的不同之处在于，它们 僵硬且更容易受到应变的微小变化[添加参考？]。 称为“生物电子学”的设备，其杨氏模量（100 Pa-10MPa）在大多数范围内 由于这种差异，候选人将加强我们的案例。 通过进一步的电气和机械测试，向 FDA 和人工耳蜗制造商本身提供帮助 测试以证明在压力下的功能性和耐用性。这些测试也将帮助我们更好地进行。 了解我们的即插即用阵列对其他神经刺激器的耐用性和可靠性限制 应用领域，如脊髓刺激器和深部脑刺激器。