Primary Care-Based Depression Prevention for Adolescents

基于初级保健的青少年抑郁症预防

• 批准号: 7685362
• 负责人: BENJAMIN W VAN VOORHEES
• 金额: $ 16.73万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7685362
• 关键词: 18 year old; Address; Adolescence; Adolescent; Adult; Adverse event; Affect; Age; Attention; Attitude; Behavior; Behavior Therapy; Behavioral; Biological Factors; Centers for Disease Control and Prevention (U.S.); Cognition; Cognitive; Communities; Conscious; Contracts; Control Groups; Coping Skills; Counseling; Depressed mood; Depressive disorder; Development; Diagnostic and Statistical Manual; Diet; Dose; Etiology; Evaluation; Exercise; Family; Feedback; Feeling hopeless; Funding; Future; Goals; Incidence; Individual; Intention; Internet; Interpersonal Relations; Intervention; Interview; Lead; Learning; Maintenance; Major Depressive Disorder; Manuals; Marketing; Measures; Modeling; Moods; Morbidity - disease rate; Motivation; Netherlands; Online Systems; Outcome; Parenting Education; Parents; Participant; Patients; Pilot Projects; Planning Theory; Preparation; Prevention; Preventive; Preventive Intervention; Primary Care Physician; Primary Health Care; Principal Investigator; Problem Solving; Process; Psychological reinforcement; Psychotherapy; Publishing; Randomized; Randomized Controlled Clinical Trials; Reading; Recruitment Activity; Recurrence; Regulation; Research; Research Personnel; Risk; Risk Factors; Role; Safety; Schedule; Self-control as a personality trait; Site; Social support; Staging; Stimulus; Structure; Substance abuse problem; Supervision; Surveys; Symptoms; Syndrome; Telephone; Theoretical model; Thinking; Time; Training; Training Programs; Treatment Efficacy; Withdrawal; Youth; age group; base; behavior change; cognitive behavior therapy; community setting; cost; depressed; depression; depressive symptoms; diabetes prevention program; efficacy evaluation; emerging adulthood; expectation; experience; follow-up; help-seeking behavior; meetings; modifiable risk; motivated behavior; motivational enhancement therapy; motivational intervention; post intervention; primary care setting; programs; protective behavior; prototype; response; skills; smoking cessation; social; social skills; stressor; treatment program; trend

DESCRIPTION (provided by applicant): Dr. Van Voorhees' long-term research objective is to reduce the morbidity of depression during the adolescence through early, preventive intervention in primary care. Primary care physicians (PCP) currently lack a defined, efficacious behavioral intervention for adolescents with sub-threshold depressive symptoms who are at risk for progressing to major depression. The proposed training program will provide him with knowledge/skills to develop/evaluate preventive interventions. Dr. Van Voorhees (Principal Investigator) has already completed a pilot study of a prototype primary care/Web-based depression prevention intervention with late adolescents (age 18-24) that demonstrated favorable trends in three risk factors. This K-08 application proposes a three-step process to systematically redesign and evaluate the potential efficacy of each component of the intervention for younger adolescents age 14-18 in preparation for an anticipated efficacy study (RO-1). Results of a stakeholder marketing survey (Study I) will inform (motivation and feasibility factors) intervention redesign for younger adolescents (Study II) leading to a pilot randomized pilot efficacy evaluation of each component. Study I will identify the key motivation (attitudes, social norms and behavioral factors) and process (dose and socio-cultural relevance) factors that will influence feasibility and efficacy in the target age group. Informed by the survey results, Study II will revise the intervention to include a comprehensive approach to reducing modifiable risk factors including parent education/engagement and behavioral activation approaches (more suited to younger adolescents). Study will evaluate the potential efficacy of each of the components of the intervention. We will recruit and randomize the 100 participants into one of two study groups: (1) control group that will be given only the address of the Internet site and receive follow-up phone call to evaluate safety, and (2) full intervention (motivational program, Ml before and after internet components and 4 motivational phone calls). We will conduct intention to treat and completer analyses of three outcomes: 1) process (dose, time on site, exercise completion), 2) post-intervention mood (CES-D score) and post-intervention risk factor/resiliency measures. These results will lead directly to an RO-1 application.

描述（由申请人提供）：Van Voorhees博士的长期研究目标是减少青春期抑郁症的发病率，通过早期的预防性干预初级保健。初级保健医生（PCP）目前缺乏对有抑郁症状的青少年的定义，有效的行为干预，他们有前进到严重抑郁症的风险。拟议的培训计划将为他提供知识/技能，以制定/评估预防性干预措施。 Van Voorhees博士（首席研究员）已经完成了一项针对初级保健/基于Web的抑郁症预防干预（18-24岁）的试点研究，该研究表现出三个危险因素的良好趋势。该K-08应用提出了一个三步的过程，以系统地重新设计并评估干预措施的每个组成部分的潜在疗效14-18岁的年轻青少年，以准备预期的效能研究（RO-1）。利益相关者营销调查（研究I）的结果将为年轻青少年（研究II）提供干预（动机和可行性因素）的干预措施，从而导致飞行员随机飞行员的效力评估每个组件。研究我将确定关键动机（态度，社会规范和行为因素）和过程（剂量和社会文化相关性）因素，这些因素将影响目标年龄组的可行性和功效。在调查结果的情况下，研究II将修改干预措施，包括一种全面的方法，用于减少可修改的风险因素，包括父母教育/参与度和行为激活方法（更适合年轻的青少年）。研究将评估干预的每个组成部分的潜在疗效。我们将招募和随机将100名参与者随机分为两个研究小组之一：（1）对照组仅给予互联网站点的地址并接收后续电话以评估安全性，以及（2）全面干预（激励计划，Internet组件之前和之后的ML和4个动机电话）。我们将采取三个结果的治疗和完成者分析的意图：1）过程（剂量，时间上的时间，锻炼完成），2）干预后情绪（CES-D分数）和干预后风险因素/弹性因素/弹性措施。这些结果将直接导致RO-1应用。