Nanoelectronic enabled chronic quantification of neurovascular coupling

纳米电子技术实现了神经血管耦合的长期定量

基本信息

批准号：
10322174
负责人：
Lan Luan
金额：
$ 17.8万
依托单位：
RICE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-12-18 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10322174
关键词：
Acute Affect Anesthesia procedures Angiotensin II Animals Blood - brain barrier anatomy Blood Pressure Brain Cerebrovascular Circulation Cerebrovascular Disorders Chronic Cicatrix Clinical Coupling Dependence Development Disease Progression Disease model Dose Electrodes Functional Magnetic Resonance Imaging Goals Health Human Hypertension Image Impairment Infarction Intervention Ischemia Knowledge Location Maps Measurement Measures Metabolic Modeling Modernization Mus Nature Nerve Degeneration Neurons Normal tissue morphology Operative Surgical Procedures Optical Methods Optics Oxygen Patients Pattern Phase Prevention strategy Research Risk Factors Role Severities Severity of illness Stimulus Stroke Surface System Techniques Therapeutic Thrombosis Tissues awake brain tissue cerebrovascular effective therapy flexibility hemodynamics high resolution imaging hypertensive imaging system implantation improved innovation longitudinal animal study mouse model multimodality nanoelectronics neuroimaging neurophysiology neurovascular coupling novel optical imaging phosphorescence preventive intervention relating to nervous system response spatiotemporal stroke model stroke patient temporal measurement

项目摘要

PROJECT SUMMARY: Neurovascular coupling, the close spatial and temporal relationship between neural activity and hemodynamics that regulates delivery of metabolic substrates to meet the demands of neuronal activation, is crucial to the structural and functional integrity of the brain. It also forms the basis of modern neuroimaging techniques such as fMRI that use hemodynamic responses to map brain function. Despite of its significant fundamental and clinical importance, the quantitative relationship between changes in hemodynamics and neural activity including the spatial extent of the coupling remains rudimentary; the quantitative effects of cerebrovascular diseases on neurovascular coupling and their dependence on the severity and progression of the diseases are understudied. Such knowledge gaps impose limitations on the precise clinical interpretation of widely applied neuroimaging techniques, and the therapeutic opportunities to clearly target the impairment of neurovascular coupling for treatment. The objective of this project is to provide spatiotemporally resolved quantification of neurovascular coupling in health and during the progression of stroke and hypertension. The hypothesis is that neurovascular coupling can be quantified and tracked by applying a novel chronic multimodal neural platform that simultaneously map both neural activity and hemodynamic parameters with high spatial- and temporal resolution over weeks to months in behaving animals. This is enabled by our recent development of a novel type of ultraflexible nanoelectronic neural electrodes that provide spatially resolved neural activity recording with seamless tissue integration and chronic optical access. We will combine these electrodes with a novel functional optical imaging system that simultaneously images and quantifies the full-field cerebral blood flow and oxygen tension (pO2). We will apply this multimodal system in behaving mice to quantify neurovascular coupling including the spatiotemporal pattern, the functional form, and the alteration due to progressing ischemia, hypertension and both. The application is highly innovative, in the applicant’s opinion, because it integrates technical advancements at multiple fronts to provide a highly novel and powerful combination of techniques that permits quantification of neurovascular coupling in previously unattainable temporal and spatial regimes. The application is significant, because it is expected to have broad translational importance both in the precise clinical interpretation of neuroimaging techniques, and in the intervention of cerebrovascular diseases where neurovascular coupling is known to be severely compromised. The long-term goal of this project is to understand the impairment of neurovascular coupling in stroke and hypertension with mechanisms similar to those occurred in human patient in order to unravel the mechanism of hypertension as the leading risk factor for stroke, and to improve prevention and intervention strategies for hypertensive stroke patients.

项目概要：神经血管耦合，神经活动与血流动力学之间密切的时空关系调节代谢底物的传递以满足神经激活的需求，对于它也构成了现代神经影像技术的基础。作为使用血流动力学反应来绘制大脑功能的功能磁共振成像，尽管它具有重要的基础和功能。临床重要性，血流动力学变化和神经活动之间的定量关系包括耦合的空间范围仍然处于初级阶段；疾病对神经血管耦合的影响及其对疾病严重程度和进展的依赖性这种知识差距限制了广泛应用的精确临床解释。神经影像技术，以及明确针对神经血管损伤的治疗机会该项目的目标是提供时空解析的量化。健康以及中风和高血压进展期间的神经血管耦合。通过应用新型慢性多模式神经平台可以量化和跟踪神经血管耦合同时映射具有高空间和时间的神经活动和血流动力学参数我们最近开发的一部小说使我们能够在几周到几个月内解决动物的行为问题。一种超柔性纳米电子神经电极，可提供空间分辨的神经活动记录我们将把这些电极与一种新颖的技术结合起来。同时对全视野脑血流进行成像和量化的功能光学成像系统我们将在行为小鼠中应用这种多模式系统来量化神经血管。耦合包括时空模式、功能形式以及由于进展而发生的变化申请人认为，该申请具有高度创新性，因为它可以治疗缺血、高血压和两者。集成了多个前沿的技术进步，提供了一种高度新颖且强大的组合允许在以前无法实现的时间和空间中量化神经血管耦合的技术该应用非常重要，因为预计它在两个方面都具有广泛的转化重要性。神经影像技术的精确临床解释以及脑血管干预已知神经血管耦合严重受损的疾病。该项目旨在了解中风和高血压中神经血管耦合的损害及其机制与人类患者发生的情况相似，以揭示高血压作为主要疾病的机制脑卒中的危险因素，并改善高血压脑卒中患者的预防和干预策略。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Spikes to Pixels: Camera Chips for Large-scale Electrophysiology.

尖峰到像素：用于大规模电生理学的相机芯片。

DOI：
发表时间：
2020-05
期刊：
影响因子：
15.9
作者：
Lycke, Roy;Sun, Liuyang;Luan, Lan;Xie, Chong
通讯作者：
Xie, Chong

Recent Advances in Electrical Neural Interface Engineering: Minimal Invasiveness, Longevity, and Scalability.

电神经接口工程的最新进展：微创性、寿命和可扩展性。

DOI：
发表时间：
2020-10-28
期刊：
影响因子：
16.2
作者：
Luan, Lan;Robinson, Jacob T;Aazhang, Behnaam;Chi, Taiyun;Yang, Kaiyuan;Li, Xue;Rathore, Haad;Singer, Amanda;Yellapantula, Sudha;Fan, Yingying;Yu, Zhanghao;Xie, Chong
通讯作者：
Xie, Chong

Dynamics of isoflurane-induced vasodilation and blood flow of cerebral vasculature revealed by multi-exposure speckle imaging.

多曝光散斑成像揭示异氟烷诱导的脑血管舒张和血流动力学。

DOI：
发表时间：
2022-01-15
期刊：
影响因子：
3
作者：
Sullender, Colin T;Richards, Lisa M;He, Fei;Luan, Lan;Dunn, Andrew K
通讯作者：
Dunn, Andrew K

Ultraflexible Neural Electrodes for Long-Lasting Intracortical Recording.

用于持久皮质内记录的超柔性神经电极。

DOI：
发表时间：
2020-08-21
期刊：
影响因子：
5.8
作者：
He, Fei;Lycke, Roy;Ganji, Mehran;Xie, Chong;Luan, Lan
通讯作者：
Luan, Lan

Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes.

神经活动和脑血流的多模态映射揭示了小规模中风后持久的神经血管解离。

DOI：
发表时间：
2020-05
期刊：
影响因子：
13.6
作者：
He, Fei;Sullender, Colin T;Zhu, Hanlin;Williamson, Michael R;Li, Xue;Zhao, Zhengtuo;Jones, Theresa A;Xie, Chong;Dunn, Andrew K;Luan, Lan
通讯作者：
Luan, Lan