Histotripsy for Benign Prostatic Hyperplasia

良性前列腺增生的组织解剖学

• 批准号: 7652503
• 负责人: William W Roberts
• 金额: $ 13.91万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7652503
• 关键词: Acute; Affect; Age; Anatomic structures; Appearance; Benign Prostatic Hypertrophy; Biomedical Engineering; Canis familiaris; Chronic; Coagulative necrosis; Collaborations; Development; Development Plans; Disease; Doctor of Philosophy; Drainage procedure; Fostering; Fractionation; Gold; Heating; Hematuria; Histocompatibility Testing; Histologic; Histology; Image; In Situ; Knowledge; Laboratories; Lasers; Left; Liquid substance; Mechanics; Mediating; Mentorship; Methods; Microbubbles; Modality; Modeling; Morbidity - disease rate; Motivation; Natural History; Necrosis; Operative Surgical Procedures; Organ; Periprostatic; Photography; Physicians; Physics; Physiologic pulse; Predisposition; Process; Property; Prostate; Prostate Ablation; Prostatic Urethra; Radiology Specialty; Rectum; Research Personnel; Scientist; Speed; Sphincter; Stress; Structure; Study models; Subcellular structure; Techniques; Technology; Testing; Thermal Ablation Therapy; Tissues; Training; Tumor Debulking; Tuna; Ultrasonic Therapy; Ultrasonography; Urinary Retention; Urination; Violence; Work; base; career development; experience; improved; in vivo; insight; interstitial; killings; men; minimally invasive; mortality; new technology; novel; pressure; programs; prostate enlargement; prostate transurethral resection; public health relevance; research study; response; standard care; treatment effect; treatment strategy; urinary

DESCRIPTION (provided by applicant): The immediate objective of this application is to develop and refine histotripsy (a novel, non-invasive ultrasound therapy that produces non-thermal mechanical tissue destruction) as a therapy for benign prostatic hyperplasia (BPH). The mechanism of tissue destruction is mediated by cavitation, a phenomenon where rapid cycling from compression to rarefaction results in formation of microbubbles within the tissue. The subsequent oscillation and violent collapse of these microbubbles mechanically breaks apart cellular and subcellular structures leaving a nonviable slurry of debris. This application seeks to foster the development of the investigator as a physician scientist by building upon established collaborations with Charles Cain, Ph.D. (Biomedical Engineering) and Brian Fowlkes, Ph.D. (Radiology and Biomedical Engineering). The career development plan combines didactic training in acoustical physics, guidance in experimental methods, and thoughtful mentorship from a cohesive, experienced researcher team. Initial tissue and acute in-vivo canine experiments are outlined to assess the susceptibility of different tissue types and anatomic structures to histotripsy induced bio-effects. This will provide insight into development of precise treatment strategies for prostate tissue fractionation and debulking without collateral damage. Using an in-vivo chronic canine model, studies are described to define the local and systemic response following histotripsy ablation of prostate tissue. PUBLIC HEALTH RELEVANCE: Prostate enlargement is a common finding in men as they age and causes difficulty with urination. Established treatments to remove this excess tissue and improve urinary drainage require invasive surgery. Less invasive alternatives that use heat to kill the excess prostate tissue have been developed but are not as effective, probably because the destroyed tissue is not actually removed. We propose to develop and test a novel technology called histotripsy, which uses ultrasound energy to mechanically break apart prostate tissue and converts it into a liquid that can be passed with urination. We believe this will result in widening of the urinary channel and improved urinary function without requiring invasive surgery.

描述（由申请人提供）： 该应用的直接目的是开发和完善组织疗法（一种新型的非侵入性超声疗法，会导致非热机械组织破坏）作为良性前列腺增生（BPH）的一种疗法。组织破坏的机制是通过空化介导的，这种现象是一种现象，其中从压缩到稀疏性的迅速循环导致组织内的微泡形成。这些微泡的随后的振荡和剧烈崩溃会机械分解细胞和亚细胞结构，留下了不可行的碎屑泥浆。 该申请旨在通过与Charles Cain博士建立合作来建立研究人员作为医师科学家的发展。 （生物医学工程）和Brian Fowlkes博士（放射学和生物医学工程）。职业发展计划结合了声学物理学的教学培训，实验方法的指导以及一个凝聚力，经验丰富的研究人员团队的体贴指导。概述了初始组织和急性体内犬类实验，以评估不同组织类型和解剖结构对组织肌肉诱导的生物效应的敏感性。这将洞悉开发前列腺组织分馏的精确治疗策略，并在没有附带损害的情况下进行延伸。使用体内慢性犬模型，描述了研究在前列腺组织的组织疗法消融后定义局部和全身反应的研究。 公共卫生相关性：前列腺扩大是男性随着年龄的增长而引起的困难的常见发现。已建立的治疗方法以去除这种多余的组织并改善尿液引流需要侵入性手术。已经开发了使用热量杀死多余前列腺组织的侵入性替代品，但没有那么有效，这可能是因为破坏的组织实际上没有被去除。我们建议开发和测试一种称为Histototy的新技术，该技术使用超声能量来机械地分解前列腺组织，并将其转化为可以在排尿时通过的液体。我们认为，这将导致尿道通道扩大并改善尿功能，而无需进行侵入性手术。