KATP channel regulation of bodily energy expenditure and weight maintenance
KATP 通道调节身体能量消耗和体重维持
基本信息
- 批准号:7666212
- 负责人:
- 金额:$ 12.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-08-01 至 2013-07-31
- 项目状态:已结题
- 来源:
- 关键词:Action PotentialsAdipose tissueAdvisory CommitteesArtsBioinformaticsBiologyBiophysicsBody WeightBody Weight decreasedCalciumCardiovascular DiseasesCardiovascular systemClinical PharmacologyComplementConfocal MicroscopyConsumptionDataDepositionDevelopment PlansDiabetes MellitusDietDiseaseEatingEducationElectrophysiology (science)Energy IntakeEnergy MetabolismEpidemicEquilibriumFailureFeedbackFoundationsGene TransferGenetic TranscriptionGrowthHomeostasisImageIncidenceIntakeInterventionInvestigationIonsIowaMalignant NeoplasmsMentorshipMetabolicMetabolic DiseasesMethodologyMolecularMolecular BiologyMorbidity - disease rateObesityObesity associated diseasePotassiumPreventionPublishingRegulationResearchResearch PersonnelResistanceResourcesRoleSignal PathwaySocietiesSodiumStriated MusclesTechniquesTherapeuticTrainingTranslationsUnited States National Institutes of HealthUniversitiesWeight GainWorkWorkloadcareercareer developmentenergy balanceexperienceinnovationmortalitymultidisciplinarynovelobesity managementpreventprogramssensorskill acquisitionskillstheoriestoolweight maintenance
项目摘要
DESCRIPTION (provided by applicant): This application describes a program of research and education to enhance the applicant's skills that will permit an independent career in investigation of molecular mechanisms of cardiovascular metabolic diseases. The applicant has a background in clinical pharmacology, electrophysiology and biophysics acquired through previous training, but requires additional theory and methodology in molecular biology, gene transfer, confocal microscopy and bioinformatics. This proposal is tailored to provide training through execution of the scientific project under mentorship of a multidisciplinary advisory committee, as well as course work and seminars. The research component will investigate molecular mechanisms of body weight maintenance and obesity resistance. Obesity has become epidemic in western society with significant increase in cardiovascular morbidity and mortality, while available treatment options remain limited. Our preliminary data indicate that the ATP-sensitive potassium (KATP) channel regulates body weight through control of energy expenditure. However, understanding of the mechanism of this KATP channel-dependent control of body weight is lacking.The central hypothesis of this proposal is that KATP channels function as metabolic feedback effectors in striated muscles to limit calcium and sodium inward currents via action potential modulation, and thus control activity-related energy consumption. Under conditions of surplus calorie intake this promotes weight gain and obesity, while KATP channel deficit results in increased energy expenditure and protects against diet-induced obesity. Aim #1 will resolve the mechanism of KATP channeldependent control of bodily energy expenditure, and Aim #2 will determine the signaling pathway for KATP channel workload-related expression control, as a tool to manipulate the channel function. Establishment of mechanisms underlying KATP channel regulation of bodily energy expenditure will identify potential therapeutic avenues for prevention of and targeted interventions for obesity management. In the short term, this scientific program in concert with the career development plan will alow the acquisition of skills and preliminary data necessary for an NIH R01 submission. In the long term, it will provide the foundation for the applicant to develop therapeutic strategies for bodily energy balance control, with direct ramification for cardiovascular disease conditions associated with obesity or energetic failure.
描述(由申请人提供):本申请描述了一项研究和教育计划,以提高申请人的技能,该计划将允许独立职业研究心血管代谢性疾病的分子机制。申请人具有通过以前的培训获得的临床药理学,电生理学和生物物理学的背景,但需要在分子生物学,基因转移,共聚焦显微镜和生物信息学方面进行其他理论和方法。该建议旨在通过在多学科咨询委员会的指导下执行科学项目,课程工作和研讨会来量身定制培训。研究成分将研究体重维持和肥胖性耐药性的分子机制。肥胖症在西方社会中已成为流行病,心血管发病率和死亡率显着增加,而可用的治疗方案仍然有限。我们的初步数据表明,ATP敏感钾(KATP)通道通过控制能量消耗来调节体重。然而,缺乏对这种KATP通道依赖性控制机制的理解。该提案的中心假设是,KATP通道在横纹肌肉中充当代谢反馈效应子,以通过动作电位模式限制钙和钠电流,从而限制与控制活性相关的能量消耗。在剩余卡路里摄入条件下,这会促进体重增加和肥胖,而KATP通道赤字会导致能量消耗增加,并防止饮食引起的肥胖症。 AIM#1将解析KATP ChannelDeldent依赖人体能量消耗的机制,而AIM#2将确定KATP通道工作负载相关的表达控制的信号传导途径,作为操纵通道函数的工具。建立KATP渠道规范身体能量消耗的机制将确定预防肥胖管理和有针对性干预措施的潜在治疗途径。在短期内,该科学计划与职业发展计划一致,将极大地获取NIH R01提交所需的技能和初步数据。从长远来看,它将为申请人提供基础,以制定身体能量平衡控制的治疗策略,并直接对与肥胖或能量衰竭相关的心血管疾病状况进行直接影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Leonid Zingman其他文献
Leonid Zingman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Leonid Zingman', 18)}}的其他基金
Myokine musclin and exercise induced cardiac conditioning
肌动蛋白和运动诱导的心脏调节
- 批准号:
10438530 - 财政年份:2020
- 资助金额:
$ 12.74万 - 项目类别:
Myokine musclin and exercise induced cardiac conditioning
肌动蛋白和运动诱导的心脏调节
- 批准号:
10553168 - 财政年份:2020
- 资助金额:
$ 12.74万 - 项目类别:
Skeletal muscle KATP channels determine bodily energy balance
骨骼肌 KATP 通道决定身体能量平衡
- 批准号:
8640933 - 财政年份:2012
- 资助金额:
$ 12.74万 - 项目类别:
Skeletal muscle KATP channels determine bodily energy balance
骨骼肌 KATP 通道决定身体能量平衡
- 批准号:
8293719 - 财政年份:2012
- 资助金额:
$ 12.74万 - 项目类别:
Skeletal muscle KATP channels determine bodily energy balance
骨骼肌 KATP 通道决定身体能量平衡
- 批准号:
8462972 - 财政年份:2012
- 资助金额:
$ 12.74万 - 项目类别:
Skeletal muscle ATP-sensitive potassium channels determine bodily energy balance
骨骼肌 ATP 敏感钾通道决定身体能量平衡
- 批准号:
8244931 - 财政年份:2011
- 资助金额:
$ 12.74万 - 项目类别:
Skeletal muscle ATP-sensitive potassium channels determine bodily energy balance
骨骼肌 ATP 敏感钾通道决定身体能量平衡
- 批准号:
8762393 - 财政年份:2011
- 资助金额:
$ 12.74万 - 项目类别:
Skeletal muscle ATP-sensitive potassium channels determine bodily energy balance
骨骼肌 ATP 敏感钾通道决定身体能量平衡
- 批准号:
8138795 - 财政年份:2011
- 资助金额:
$ 12.74万 - 项目类别:
Skeletal muscle ATP-sensitive potassium channels determine bodily energy balance
骨骼肌 ATP 敏感钾通道决定身体能量平衡
- 批准号:
8597362 - 财政年份:2011
- 资助金额:
$ 12.74万 - 项目类别:
KATP channel regulation of bodily energy expenditure and weight maintenance
KATP 通道调节身体能量消耗和体重维持
- 批准号:
7888343 - 财政年份:2008
- 资助金额:
$ 12.74万 - 项目类别:
相似国自然基金
脂肪组织新型内分泌因子的鉴定及功能研究
- 批准号:82330023
- 批准年份:2023
- 资助金额:220 万元
- 项目类别:重点项目
脂肪干细胞外泌体miRNA-299a-3p调控巨噬细胞Thbs1缓解脂肪组织衰老的机制研究
- 批准号:82301753
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
血管周围脂肪组织TRPV1通道通过脂联素调控肥胖相关高血压的机制研究
- 批准号:82300500
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
糖尿病脂肪组织中SIRT3表达降低进而上调外泌体miR-146b-5p促进肾小管脂毒性的机制研究
- 批准号:82370731
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
CXCL1/CXCR2信号轴上调Bcl-2促进筋膜定植巨噬细胞迁移在皮下脂肪组织原位再生中的机制研究
- 批准号:82360615
- 批准年份:2023
- 资助金额:32 万元
- 项目类别:地区科学基金项目
相似海外基金
Highly Elastic Biomaterial Development for Urethral Application
尿道应用的高弹性生物材料开发
- 批准号:
10573094 - 财政年份:2023
- 资助金额:
$ 12.74万 - 项目类别:
Mechanisms Underlying the Omental Support of Ovarian Cancer Peritoneal Metastasis
卵巢癌腹膜转移的大网膜支持机制
- 批准号:
10678068 - 财政年份:2023
- 资助金额:
$ 12.74万 - 项目类别:
Functions of the rete ovarii in ovary development, adult homeostasis, and female reproductive longevity
卵巢网在卵巢发育、成人体内平衡和女性生殖寿命中的功能
- 批准号:
10828038 - 财政年份:2023
- 资助金额:
$ 12.74万 - 项目类别:
Support Mentoring of Early Career Clinical Researchers from Diverse Backgrounds
支持来自不同背景的早期职业临床研究人员的指导
- 批准号:
10797859 - 财政年份:2023
- 资助金额:
$ 12.74万 - 项目类别:
A Pathogenic Role for the Natriuretic Peptide Clearance Receptor in Heart Failure with Preserved Ejection Fraction.
钠尿肽清除受体在射血分数保留的心力衰竭中的致病作用。
- 批准号:
10589324 - 财政年份:2023
- 资助金额:
$ 12.74万 - 项目类别: