Mentoring and research to prepare oral PrEP delivery platforms for novel HIV prevention products

指导和研究，为新型艾滋病毒预防产品准备口服 PrEP 递送平台

基本信息

批准号：
10322040
负责人：
Renee A. Heffron
金额：
$ 2.45万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-01 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10322040
关键词：
AIDS prevention Adherence Africa African African American population Award Behavioral Sciences Clinical Clinical Research Cognitive Communicable Diseases Communities Counseling Dapivirine Doctor of Philosophy Dose Epidemiologist Epidemiology Evaluation Faculty Female Funding Grant HIV HIV Infections HIV risk Home Hour Incidence Injectable International Interview Kenya Lesotho Manuscripts Mentors Methods Modality Oral Persons Phase III Clinical Trials Postdoctoral Fellow Preparation Prevention Research Provider Qualitative Research Reproductive Health Research Research Assistant Research Personnel Safety Science Scientist South Africa Structure Tenofovir Time Training Translational Research Uganda Underrepresented Populations United States National Institutes of Health Universities Vaginal Ring Vision Washington Woman Work base career design doctoral student experience experimental study global health implementation research implementation science informant meetings mid-career faculty next generation novel patient oriented research phase III trial pill pre-doctoral pre-exposure prophylaxis preference programs side effect skills social theories uptake young woman

项目摘要

ABSTRACT This is a career mentoring award to support Dr. Renee Heffron, Associate Professor at the University of Washington, with protected time to create a more structured approach to mentoring for herself and her colleagues and to increase the number of mentees that she has by at least 50%. Mentees will be among the next generation of researchers focused on HIV prevention, oral pre-exposure prophylaxis (PrEP), and novel PrEP products. Dr. Heffron, PhD, MPH is a clinical epidemiologist with advanced training in implementation science, behavioral science, and qualitative research. Dr. Heffron's mentoring style is grounded in the Social Cognitive Career Theory and includes emphasis on developing mentee's science identify. Mentees will work alongside Dr. Heffron on the newly proposed research in the K24 in the realm of implementation science as well as on her four ongoing NIH-funded studies in Uganda, Kenya, and South Africa. Mentoring aims are to: 1. Support and grow the next generation of US- and Africa-based leaders conducting patient-oriented research focused on delivery of oral PrEP and novel PrEP products through the provision of structured mentoring to a total of 20-40 (~5 new mentees/year) pre-doctoral students, postdoctoral fellows, junior faculty, and other junior investigators, including subsets who are female and identify as being from URG. 2. Establish and refine a structured mentoring program within the International Clinical Research Center, my research home within the University of Washington Department of Global Health. Newly proposed research provides opportunity for Dr. Heffron to grow her repertoire of work in implementation science, in order to identify best practices to integrate novel PrEP products into existing platforms for oral PrEP delivery by conducting 60 key informant qualitative interviews with experts developing novel PrEP products, PrEP program implementers, and end users who discontinued or rejected use of oral PrEP. A discrete choice experiment will be conducted with young women in Uganda to identify their preferences for different attributes of HIV prevention counseling and whether counseling scenarios would facilitate uptake of a PrEP product. Research specific aims are to: 1. Define a preliminary strategy for the integration of novel PrEP products (e.g., injectable Cabotegravir, Dapivirine intravaginal ring, TFV/LNG intravaginal ring) into existing oral PrEP programs by conducting qualitative interviews with experts in novel PrEP products, oral PrEP programs, and end users 2. Among young women who have discontinued or never initiated oral PrEP, to determine preferences for attributes of HIV prevention counseling that would support them to initiate and sustain use of a PrEP product

抽象的这是一个职业指导奖，旨在支持英国大学副教授 Renee Heffron 博士。华盛顿，有受保护的时间为她自己和她的人创建一种更加结构化的指导方法并将她的受指导者数量增加至少 50%。受训者将是其中下一代研究人员专注于艾滋病毒预防、口腔暴露前预防 (PrEP) 和新型药物 PrEP 产品。 Heffron 博士，博士，公共卫生硕士是一位临床流行病学家，接受过高级实施培训科学、行为科学和定性研究。赫夫隆博士的指导风格植根于社会认知职业理论，包括强调发展受训者的科学认同。学员将工作与 Heffron 博士一起参与 K24 在实施科学领域新提出的研究正如她在乌干达、肯尼亚和南非正在进行的四项由美国国立卫生研究院资助的研究一样。辅导的目的是： 1. 支持和培养下一代美国和非洲领导人进行以患者为导向的研究专注于通过提供结构化指导来提供口服 PrEP 和新型 PrEP 产品总共 20-40 名（每年约 5 名新学员）博士前学生、博士后研究员、初级教师和其他人员初级研究人员，包括来自 URG 的女性子集。 2. 在我的国际临床研究中心内建立和完善结构化的指导计划华盛顿大学全球健康系的研究中心。新提出的研究为 Heffron 博士提供了在实施过程中拓展工作范围的机会科学，以确定将新型 PrEP 产品整合到现有口服 PrEP 平台中的最佳实践通过与开发新型 PrEP 产品的专家进行 60 次关键知情人定性访谈来交付， PrEP 计划实施者以及停止或拒绝使用口服 PrEP 的最终用户。离散的选择将对乌干达的年轻女性进行实验，以确定她们对不同属性的偏好 HIV 预防咨询以及咨询场景是否会促进 PrEP 产品的使用。研究的具体目标是： 1. 制定整合新型 PrEP 产品的初步策略（例如注射用 Cabotegravir、将达匹韦林阴道环、TFV/LNG 阴道环）纳入现有的口服 PrEP 计划，通过进行对新型 PrEP 产品、口服 PrEP 项目和最终用户的专家进行定性访谈 2. 在已停止或从未开始口服 PrEP 的年轻女性中，确定对以下药物的偏好： HIV 预防咨询的属性将支持他们开始并持续使用 PrEP 产品