Microbiome-Balancing Wraps for Managing Eczema

用于治疗湿疹的微生物组平衡裹敷

基本信息

批准号：
10324997
负责人：
Hanumantharao Paritala
金额：
$ 25.3万
依托单位：
CFD RESEARCH CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10324997
关键词：
Academy Adverse effects Advisory Committees Affect Alternative Therapies American Amides Anabolism Antibiotics Area Arthrodermataceae Atopic Dermatitis Atrophic Bandage Biological Assay Branched-Chain Amino Acids Cell Wall Cells Coin Colony-forming units Complementary therapies Dermal Dermatology Dose Early treatment Eczema Equilibrium Esters Fibroblasts Flare Goals Gossypium Growth Hot Springs Hydrolysis In Vitro Infection Kinetics Link Maximum Tolerated Dose Measures Methods Modeling Monograph Mucous Membrane Mus Natural Products Organism Pathogenicity Patients Pharmaceutical Chemistry Pharmaceutical Preparations Phase Play Positioning Attribute Prevalence Prevention Problem Solving Pruritus Publishing Reading Regimen Reporting Research Role Rosacea Roseomonas Sampling Silicones Skin Specificity Staphylococcus aureus Staphylococcus epidermidis Steroids Structure-Activity Relationship Substance Withdrawal Syndrome Symptoms Technology Testing Textiles Toxic effect Trichophyton Water Western World addiction aminoacid biosynthesis analog antimicrobial base beneficial microorganism covalent bond cytotoxicity dysbiosis in vivo indexing intraperitoneal microbiome microorganism natural antimicrobial novel pathogen prevent programs prototype side effect skin microbiome steroid dependence

项目摘要

Project Summary/Abstract: The long-term goal of this project is to develop microbiome-balancing antimicrobial wraps to use in the treatment of atopic dermatitis or eczema infections. The topical steroids used in the treatment of atopic dermatitis cause many side-effects and addiction. Additionally, the antibiotics used to treat AD infections eliminate skin commensals along with the targeted pathogens, resulting in skin microbial imbalance. Skin commensals play an important role in preventing the re-colonization and re- occurrence of the eczema by inhibiting the pathogens. Protective wraps or wet wraps made of skin commensal gentle antimicrobial compounds can prevent atopic dermatitis by promoting the growth of skin beneficial microbes and inhibiting the skin pathogens. CFD Research has discovered novel natural product-based compounds with skin commensal gentle targeted antimicrobial activity. In this proposal we seek to develop skin microbiome-gentle antimicrobial cotton fabrics that can release the compound at a certain rate to inhibit the pathogens while promoting growth of skin commensals.

项目摘要/摘要：该项目的长期目标是开发微生物组平衡的抗菌包装，用于治疗特应性皮炎或湿疹感染。用于治疗的局部类固醇特应性皮炎会引起许多副作用和成瘾。此外，用于治疗 AD 的抗生素感染消除了皮肤共生体以及目标病原体，导致皮肤微生物不平衡。皮肤共生体在防止重新定植和重新定植方面发挥着重要作用。通过抑制病原体来抑制湿疹的发生。皮肤制成的防护包裹或湿包裹共生的温和抗菌化合物可以通过促进生长来预防特应性皮炎皮肤有益微生物并抑制皮肤病原体。 CFD 研究发现了新颖的基于天然产物的化合物，具有皮肤共生温和的针对性抗菌活性。在这个我们寻求开发皮肤微生物组温和的抗菌棉织物，可以释放以一定的比例复合抑制病原体，同时促进皮肤共生体的生长。