Cherokee Nation Native AmericanResearch Center for Health

切罗基族美洲原住民健康研究中心

• 批准号: 10293108
• 负责人: SOHAIL Imran KHAN
• 金额: $ 131.75万
• 依托单位: CHEROKEE NATION
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10293108
• 关键词: Address; Adult; Alaska Native; American Indians; Area; Biological Sciences; Businesses; COVID-19; COVID-19 impact; COVID-19 point of care; COVID-19 prevention; COVID-19 risk; COVID-19 testing; Cherokee Indian; Cherokee Nation, Oklahoma; Clinic; Clinical Research; Communities; Community Surveys; Contact Tracing; County; Data; Data Reporting; Disease; Disease Outbreaks; Education; Educational Materials; Effectiveness; Electronic Health Record; Ensure; Ethics; Ethnic group; Evaluation; Event; FDA Emergency Use Authorization; Foundations; Future; Geography; Health; Health Sciences; Health Service Area; Health Services; Health system; Hepatitis C virus; Human Resources; Immunoassay; Immunologic Markers; Indian reservation; Inflammatory; Infrastructure; Interview; Laboratory Personnel; Lateral; Leadership; Medical; Medical Research; Modeling; Molecular; Monitor; Native-Born; Oklahoma; Outcome; Patient Education; Patients; Perception; Persons; Population; Populations at Risk; Poverty; Prevalence; Public Health; RADx; RADx Underserved Populations; Reporting; Reservations; Risk; Risk Factors; Rural; Rural Community; Rural Population; SARS-CoV-2 antibody; Schools; Serum; Site; Solid; Testing; Travel; Underserved Population; Universities; Vaccination; Viral; Viral Antibodies; Writing; aged; base; biobank; clinical care; community barrier; community engagement; community transmission; comorbidity; design; experience; geographic barrier; human subject; informant; insight; instrument; novel; point of care testing; programs; protective factors; public health intervention; racial and ethnic; respiratory; respiratory pathogen; rural area; screening; severe COVID-19; social implication; testing uptake; tribal health; tribal member

PROJECT SUMMARY Through the RADx-UP program, the Cherokee Nation Community-Driven Program for Testing and Contact Tracing (Cherokee PROTECT) unites tribal, academic, and community partners under the leadership of Cherokee Nation (CN) to solve a dire need for COVID-19 testing, contact tracing, and culturally informed education in underserved and vulnerable rural populations. As of August 4, Cherokee Nation Health Services (CNHS) has confirmed >850 cases of COVID-19 in the tribal populations served across mainly rural northeastern Oklahoma. Community spread of COVID-19 exists throughout all 14 counties in the CN reservation, but with CN’s limited capacity for community testing, screening, and contact tracing, the true impact of COVID-19 is unknown. Roughly 34% of American Indian/Alaska Native (AI/AN) adults aged 18-64 years are at risk of severe COVID-19 due to comorbidities, more than any other racial/ethnic group in the US. Five counties in CN are in the top 20% of US counties for the prevalence of adults at risk of severe COVID-19 due to underlying medical conditions; this vulnerability is compounded by high poverty rates and geographic barriers. People living in rural areas of CN may have to travel as many as 60 miles round-trip for viral testing. Most COVID-19 testing in CN to date has been conducted through CNHS, the largest tribally compacted health system in the US that serves all AI/AN people living within the CN reservation. Although CNHS accounts for approximately 8.5% of all IHS active user population and 38% of active user population of Oklahoma service area, not all tribal members residing in the reservation access CNHS, and therefore, may not be tested by CNHS. Other than CNHS clinics, 7 of 14 counties in this area have only one public testing site, and results may not be returned for 2-3 weeks. CNHS and its closely integrated CN Public Health program have an exemplary 20-year record of delivering public health interventions, including a groundbreaking Hepatitis C Virus elimination program with the University of Oklahoma Health Sciences Center, and ongoing projects with >40 rural K-12 schools. Through collaborative clinical research and molecular studies, CN and the Oklahoma Medical Research Foundation have identified new immune biomarkers in tribal populations. Drawing on these existing strengths and infrastructure, Cherokee PROTECT will (1) Build infrastructure and increase FDA-EUA COVID-19 viral and antibody testing for clinical care in CNHS; (2) Enable community-based COVID-19 testing, contact tracing, and education with CN Public Health; (3) Identify barriers and facilitators to COVID-19 testing in the CN reservation to inform a tailored educational campaign to increase testing and contact tracing, and decrease spread; and (4) Implement a rigorous evaluation to ensure quality improvement and sustainability.

项目概要 通过 RADx-UP 计划，切罗基族社区驱动的测试和接触计划 追踪 (Cherokee PROTECT) 在以下人员的领导下将部落、学术和社区合作伙伴团结起来 Cherokee Nation (CN) 致力于解决对 COVID-19 检测、接触者追踪和文化了解的迫切需求 截至 8 月 4 日，切罗基国家卫生服务中心为服务不足和弱势的农村人口提供教育。 (CNHS) 已确认，主要服务于农村地区的部落人口中出现超过 850 例 COVID-19 病例 俄克拉荷马州东北部，新冠肺炎 (COVID-19) 的社区传播遍及美国全国 14 个县。 保留，但由于 CN 的社区检测、筛查和接触者追踪能力有限，真正的情况 大约 34% 的 18-64 岁美洲印第安人/阿拉斯加原住民 (AI/AN) 成年人受到 COVID-19 的影响尚不清楚。 因合并症而面临严重 COVID-19 风险的人群比美国任何其他种族/族裔群体都要高。 加拿大有 5 个县的成人重症 COVID-19 患病率位居美国县前 20% 由于基本的医疗条件，这种脆弱性因高贫困率和地理因素而加剧； 居住在中国农村地区的人们可能需要往返 60 英里才能进行病毒检测。 迄今为止，CN 的大多数 COVID-19 检测都是通过 CNHS 进行的，CNHS 是最大的部落压缩卫生机构 尽管 CNHS 占了美国的系统，但它为居住在 CN 保留地内的所有 AI/AN 人提供服务。 约占 IHS 所有活跃用户群体的 8.5% 和俄克拉荷马州服务活跃用户群体的 38% 地区，并非所有居住在保留地的部落成员都可以访问 CNHS，因此，可能不会接受测试 除 CNHS 诊所外，该地区 14 个县中有 7 个县只有一个公共检测点，结果可能会有所不同。 2-3 周内不会返回 CNHS 及其紧密结合的 CN 公共卫生计划堪称典范。 提供公共卫生干预措施（包括突破性丙型肝炎病毒）的 20 年记录 与俄克拉荷马大学健康科学中心合作的消除计划，以及与超过 40 名合作伙伴正在进行的项目 通过农村合作临床研究和分子研究，CN 和俄克拉荷马州的 K-12 学校。 医学研究基金会利用这些在部落人群中发现了新的免疫生物标志物。 现有优势和基础设施，Cherokee PROTECT 将 (1) 建设基础设施并增加 FDA-EUA (2) 启用基于社区的 COVID-19 测试， 接触者追踪以及 CN 公共卫生部门的教育；(3) 确定 COVID-19 检测的障碍和促进因素 在 CN 保留区中，为量身定制的教育活动提供信息，以加强检测和接触者追踪，以及 减少传播；(4) 实施严格的评估，以确保质量改进和可持续性。

项目成果

Expanded Autoantibody Profiles for Subsetting of Native American, African American, and European American Patients With Systemic Lupus Erythematosus.

扩展了美洲原住民、非裔美国人和欧洲裔美国人系统性红斑狼疮患者的自身抗体谱。

• 发表时间: 2020-07
• 影响因子: 3.4
• 作者: Guthridge, Carla J;Gross, Timothy;Quintero, Magdalene;Kheir, Joseph M;Levin, Jeremy;Bourn, Rebecka L;Khan, Sohail;Peercy, Michael;Saunkeah, Bobby;Guthridge, Joel M;James, Judith A
• 通讯作者: James, Judith A

Development and Implementation of an HPV Vaccination Survey for American Indians in Cherokee Nation.

针对切罗基族印第安人的 HPV 疫苗接种调查的制定和实施。

• 发表时间: 2021-09-01
• 作者: Gopalani, Sameer Vali;Janitz, Amanda E;Burkhart, Margie;Campbell, Janis E;Martinez, Sydney A;White, Ashley H;Chen, Sixia;Anderson, Amber S;Pharr, Stephanie F;Patrick, Scott;Comiford, Ashley
• 通讯作者: Comiford, Ashley

Unique Serum Immune Phenotypes and Stratification of Oklahoma Native American Rheumatic Disease Patients.

俄克拉荷马州美洲原住民风湿病患者的独特血清免疫表型和分层。

• 发表时间: 2023-04
• 影响因子: 4.7
• 作者: Slight;Guthridge, Carla J;Kheir, Joseph;Chen, Hua;Tran, Ly;Gross, Tim;Roberts, Virginia;Khan, Sohail;Peercy, Michael;Saunkeah, Bobby;Guthridge, Joel M;James, Judith A
• 通讯作者: James, Judith A