Molecular basis for stress-induced gene regulation—a model system to understand transcriptional deregulation in cancer and neurological disease

应激诱导基因调控的分子基础——了解癌症和神经系统疾病转录失调的模型系统

• 批准号: nhmrc : 1125909
• 负责人: Dr Andrew Ellisdon
• 金额: $ 26.2万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-basis-stress-neurological-disease/947689
• 关键词: Molecular; basis; stress; induced; gene

Deregulated gene transcription plays a critical role in cancer formation. It is therefore important to understand the molecular basis of gene transcription and how tumour cells hijack the process. In this Project, we will study the molecular basis of stress-inducible gene expression. This is particularly important for understanding the molecular basis of cancer as stress-inducible genes are activated by transcription factors implicated in breast, colon, lung, and prostate cancers.

失调的基因转录在癌症形成中起着至关重要的作用。因此，了解基因转录的分子基础以及肿瘤细胞如何劫持该过程非常重要。在这个项目中，我们将研究应激诱导基因表达的分子基础。这对于理解癌症的分子基础尤其重要，因为应激诱导基因是由乳腺癌、结肠癌、肺癌和前列腺癌中涉及的转录因子激活的。