Adherence with Sleep Apnea Treatments: A Meta-Analysis

睡眠呼吸暂停治疗的依从性：荟萃分析

• 批准号: 7656815
• 负责人: Carl J. Stepnowsky
• 金额: $ 4.97万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-11 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7656815
• 关键词: Adherence; Sleep; Apnea; Treatments; Meta

DESCRIPTION (PROVIDED BY APPLICANT): An estimated 70 million people in the United States suffer from sleep problems, and more than half of them have a sleep disorder that is chronic. Sleep problems and disorders have major societal impacts including drowsy driving accidents and deaths, lost productivity, and high costs. One of the key research recommendations put forth by both the 2003 National Sleep Disorders Research Plan and a recent NIH workshop is a better understanding of sleep disorders treatments, including adherence to those treatments, in order to inform evidence-based guidelines for the improved management of sleep disorders. The most prevalent class of sleep disorders are Sleep-Related Breathing Disorders (SRBD), and in particular, obstructive sleep apnea (OSA). SRBD treatment regimens include medical devices, oral appliances, and behavioral recommendations. Nonadherence (noncompliance) occurs when individuals do not successfully carry out the health behavior recommendations made by their health professionals, and is a widespread behavioral problem that results in wasted health care visits, expensive and dangerous medical complications, failures of treatment, and missed opportunities to improve and maintain quality of life. The databases of the National Library of Medicine contain scientific journal articles published from all over the world on SRBD treatment adherence yet there exists little empirically based consensus regarding how best to solve this serious, largely behavioral problem. This project will systematically search the PubMed database (supplemented by PsyInfo and the Cochrane Central Register of Controlled Trials) and use the techniques of meta-analysis to organize, quantitatively summarize, and statistically integrate the results of all published empirical research analyzing all correlates, determinants, and consequences of patient adherence (compliance) to interventions for SRBD that are given by healthcare providers. An organized, empirically-based framework of explanatory factors that capture the broad range of influences on patient adherence to many varying aspects of SRBD management will be used. Calculation of multiple, conceptually driven meta-analyses will entail the collection and statistical combination of effect sizes, and will contribute to the building of straightforward data-driven models to achieve a detailed understanding of patient adherence as a mediator of health outcomes. The goal of the project is to identify necessary future research strategies and factors with the greatest potential for behavioral intervention to increase adherence and improve health outcomes for SRBD patients.

描述（由申请人提供）：美国估计有7000万人患有睡眠问题，其中一半以上患有慢性睡眠障碍。睡眠问题和疾病具有重大的社会影响，包括昏昏欲睡的驾驶事故和死亡，生产力失去和高昂的成本。 2003年国家睡眠障碍研究计划和最近的NIH研讨会提出的重要研究建议之一是对睡眠障碍治疗（包括遵守这些疗法）的更好理解，以便为改善睡眠障碍管理的基于证据的指南提供指导。最普遍的睡眠障碍类别是与睡眠有关的呼吸障碍（SRBD），尤其是阻塞性睡眠呼吸暂停（OSA）。 SRBD治疗方案包括医用设备，口服电器和行为建议。当个人没有成功执行其卫生专业人员提出的健康行为建议时，就会发生不遵守（不遵守），并且是一个广泛的行为问题，导致浪费医疗访问，昂贵且危险的医疗并发症，治疗失败以及改善和维持生活质量的失误机会。国家医学图书馆的数据库包含有关SRBD治疗依从性的科学期刊文章，但几乎没有关于如何最好地解决这一严重的，在很大程度上的行为问题上的共识。该项目将系统地搜索PubMed数据库（由Psyinfo和Cochrane Central登记对照试验补充），并使用荟萃分析的技术来组织，定量总结和统计地整合所有已发表的经验研究的结果，从提供者。将使用一个有组织的基于经验的解释因素框架，该框架将使用对患者遵守的广泛影响SRBD管理的许多不同方面的影响。多个概念上驱动的荟萃分析的计算将需要效应大小的收集和统计组合，并有助于建立直接数据驱动的模型，以详细了解患者依从性作为健康结果的中介。该项目的目的是确定具有行为干预潜力最大的未来研究策略和因素，以提高依从性并改善SRBD患者的健康状况。