Institutional Career Development Core

机构职业发展核心

• 批准号: 10398853
• 负责人: Miriam Antoinette Bredella
• 金额: $ 136.37万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10398853
• 关键词: Academy; Address; Advisory Committees; Appointment; Award; Budgets; Clinical; Clinical Investigator; Clinical Research; Communities; Competence; Complex; Custom; Development; Disease; Diverse Workforce; Enrollment; Ensure; Environment; Faculty; Fellowship; Financial Support; Foundations; Funding; Future; Grant; Health; Individual; Industry; Institutes; K-Series Research Career Programs; Learning; Link; Longevity; Medical; Mentored Clinical Scientist Development Program; Mentors; Mentorship; Mission; Modeling; National Center for Advancing Translational Sciences; Peer Review; Performance; Positioning Attribute; Process; Program Development; Research; Research Methodology; Research Personnel; Resources; Risk; SECTM1 gene; Science; Special Population; Training; Training Support; Translational Research; United States National Institutes of Health; Universities; Work; base; career; career development; catalyst; community building; education research; faculty mentor; faculty support; human disease; improved; innovation; medical schools; next generation; programs; spelling; success; translational scientist

I. INSTITUTIONAL CAREER DEVELOPMENT CORE – KL2 PROGRAM: ABSTRACT The Harvard Catalyst (HC) KL2 Program is the cornerstone across Harvard University (HU) and its affiliated academic health centers (AHCs) to train the future leaders in clinical and translational research. The KL2 program admits, by a highly competitive process, CT investigators who are within the first 3 years of their initial faculty appointment at HU. Over the period of this award, to meet CTSA requirements and budget reductions, the HC KL2 program will admit 14 awardees in year 1, 13 awardees in year 2, 10 awardees in year 3, and will reach the 9 allowable slots by year 4. Each KL2 awardee will be enrolled for a period of two years to allow him/her to acquire by the end of the award period: 1) Subsequent peer-reviewed funding from the NIH or disease-specific foundation grants, and 2) Further support and acknowledgement at their AHCs as CT investigators who are critical to the institutional mission as documented by financial support and a clear track for promotion. These are the two key metrics of success of the HC KL2 program. To accomplish this, the KL2 program will create a community for junior CT investigators to enhance their transition to independence. The KL2 Program proposes four specific aims: (Aim 1) Select, mentor, and train HC KL2 trainees, and provide a supportive Harvard-wide environment that ensures their success, and develops and sustains a robust community of junior CT research investigators; (Aim 2) Optimize and individually tailor a customized educational program that supports the training of KL2 trainees so that they become independent, collaborative, and team science-based investigators committed to combating the most complex human diseases and health problems; (Aim 3) Evaluate and continuously improve individual and team mentorship models that support successful development and career progression of diverse HC KL2 trainees; and (Aim 4) Ensure that metrics of success are continually used to identify and improve components of the program that most effectively support career progression and transition of KL2 awardees to independence. These aims will be completed with the contributions of outstanding faculty mentors, HC Cores that enhance education and research methodology, and innovative HC programs that encourage team science and ensure a diverse workforce. KL2 graduates will become fully independent CT investigators capable of addressing unmet medical needs, and in turn, training the next generation of CT investigators.

I. 机构职业发展核心 – KL2 计划：摘要 哈佛催化剂 (HC) KL2 计划是哈佛大学 (HU) 及其附属机构的基石 学术健康中心 (AHC) 培训临床和转化研究的未来领导者。 该计划通过高度竞争的流程录取在其初始职位的前 3 年内的 CT 调查员 在此期间，为满足 CTSA 要求和预算削减，HU 的教职人员任命。 HC KL2 计划将在第一年录取 14 名获奖者，在第二年录取 13 名获奖者，在第三年录取 10 名获奖者，并将 到第 4 年达到 9 个允许的名额。 每个 KL2 获奖者将注册两年，以便他/她在获奖结束时获得 期间：1) 来自 NIH 或特定疾病基金会拨款的后续同行评审资金，以及 2) 作为对机构至关重要的 CT 调查员，获得 AHC 的进一步支持和认可 财务支持记录的使命和明确的晋升轨迹是两个关键指标。 HC KL2 计划的成功 为了实现这一目标，KL2 计划将为初级 CT 创建一个社区。 调查人员加强向独立的过渡。 KL2 计划提出了四个具体目标：（目标 1）选择、指导和培训 HC KL2 学员，并提供 哈佛范围内的支持性环境，确保他们的成功，并发展和维持强大的 初级 CT 研究人员社区；（目标 2）优化并个性化定制 支持 KL2 学员培训的教育计划，使他们变得独立、协作、 和团队以科学为基础的研究人员致力于对抗最复杂的人类疾病和健康 （目标 3）评估并持续改进支持的个人和团队指导模型 多样化的 HC KL2 学员的成功发展和职业发展；以及（目标 4）确保指标 成功的经验不断地被用来识别和改进项目中最有效的组成部分 支持 KL2 获奖者的职业发展和向独立过渡。这些目标将得以完成。 在杰出教师导师的贡献下，HC 核心加强了教育和研究 方法论和创新的 HC 计划，鼓励团队科学并确保 KL2 的员工队伍多元化。 毕业生将成为完全独立的 CT 研究人员，能够解决未满足的医疗需求，并在 反过来，培训下一代 CT 调查员。

项目成果

Neuroimaging considerations when investigating choroid plexus morphology in idiopathic psychosis.

研究特发性精神病脉络丛形态时的神经影像学注意事项。

• 发表时间: 2020
• 影响因子: 4.5
• 作者: Bannai, Deepthi;Lutz, Olivia;Lizano, Paulo
• 通讯作者: Lizano, Paulo

Clinical application of esophageal manometry: how I do it.

食管测压的临床应用：我是如何做的。

• 发表时间: 2021-01-05
• 作者: Baedorf Kassis, Elias;Talmor, Daniel
• 通讯作者: Talmor, Daniel

Association of Teaching Status and Mortality After Cancer Surgery.

教学状况与癌症手术后死亡率的协会。

• 发表时间: 2021-09
• 作者: Lam, Miranda B;Riley, Kristen;Mehtsun, Winta;Phelan, Jessica;Orav, E John;Jha, Ashish K;Burke, Laura G
• 通讯作者: Burke, Laura G

Penile Artery 18F-NaF Uptake and Erectile Dysfunction: Off-Target Molecular Insights.

阴茎动脉 18F-NaF 摄取和勃起功能障碍：偏离目标的分子见解。

• 发表时间: 2019
• 影响因子: 24
• 作者: Tawakol, Ahmed;Osborne, Michael T;McGovern, Francis J
• 通讯作者: McGovern, Francis J

Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance.

单细胞谱系分析揭示了胶质母细胞瘤耐药性中遗传和表观遗传的相互作用。

• 发表时间: 2020-07-15
• 影响因子: 12.3
• 作者: Eyler, Christine E;Matsunaga, Hironori;Hovestadt, Volker;Vantine, Samantha J;van Galen, Peter;Bernstein, Bradley E
• 通讯作者: Bernstein, Bradley E