Molecular Pharmacology Training Program

分子药理学培训项目

• 批准号: 10398169
• 负责人: JAMES K CHEN
• 金额: $ 41.63万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10398169
• 关键词: Molecular; Pharmacology; Training Programs

Pharmacology is at a crossroads. Although technological advances in chemistry and biology have transformed drug discovery, our ability to develop new therapeutics has lagged behind our clinical needs. This gap reflects a disconnect between basic science discovery and translational research, and addressing this challenge will require scientists who can bridge these two areas. Toward this goal, the Stanford Molecular Pharmacology Training Program (MPTP) aims to empower predoctoral students across the biosciences with specialized training in drug discovery and development. The MPTP is founded on the rich history of pharmacology research and education at Stanford, and it now transcends conventional academic boundaries. Our training program draws upon an outstanding group of 26 highly collaborative Stanford faculty from multiple departments, and it builds upon the strength of SPARK, a translational research initiative that was created at Stanford in 2006. In addition to their independent research with MPTP faculty, our trainees receive formal course work in drug discovery, and they attend weekly presentations by SPARK-affiliated experts in pharma/biotech, patent law, venture capital, clinical medicine, and other areas related to therapeutic development. MPTP students also participate in summer biotech internships and clinical shadowing opportunities, supplementing their academic training with industrial and clinical experiences. These training activities are integrated with courses on the responsible conduct of research, rigor, and reproducibility, weekly student/faculty research forums, annual retreats, grant writing and science communication workshops, and outreach opportunities. Our predoctoral students are also encouraged to propose translational projects, which are reviewed and funded by SPARK on a competitive basis. These team-based projects provide hands- on, real-world experience in therapeutic development and direct interactions with industry veterans and experts. Our program carefully tracks student research progress, faculty mentorship, and program effectiveness to enable the MPTP to continually evolve to meet its educational mission. To train scientific leaders and innovators who will impact communities throughout the United States, we have also established recruitment and retention strategies to foster student diversity, leveraging Stanford resources and mobilizing the MPTP community. Through its innovative curriculum and partnerships with SPARK and industry, the MPTP will impart its students with rigorous training in basic science and an understanding of drug discovery and development. Graduates of our training program will be uniquely able to translate fundamental discoveries into clinical advances, and they will be well- positioned to become scientific leaders in academia, industry, government, and other sectors.

药理学正处于十字路口。尽管化学和生物学的技术进步已经改变了 药物发现，我们开发新疗法的能力已经落后于我们的临床需求。这一差距反映了 基础科学发现和转化研究之间的脱节，解决这一挑战需要 能够弥合这两个领域的科学家。为了实现这一目标，斯坦福大学分子药理学培训计划 （MPTP）旨在为生物科学领域的博士前学生提供药物发现和药物发现方面的专门培训 发展。 MPTP 建立在斯坦福大学丰富的药理学研究和教育历史之上，现在 超越了传统的学术界限。我们的培训计划吸引了 26 名优秀的团队 斯坦福大学多个院系的教职人员合作，它建立在 SPARK 的优势之上，SPARK 是一个转化型 该研究计划于 2006 年在斯坦福大学创建。除了与 MPTP 教员的独立研究之外， 我们的学员接受药物发现的正式课程作业，并参加 SPARK 附属机构每周的演示 制药/生​​物技术、专利法、风险投资、临床医学和其他与治疗相关领域的专家 发展。 MPTP 学生还参加暑期生物技术实习和临床见习机会， 用工业和临床经验补充他们的学术培训。 这些培训活动与负责任的研究行为、严谨性和 可重复性、每周学生/教师研究论坛、年度静修、资助写作和科学交流 研讨会和外展机会。我们还鼓励我们的博士前学生提出转化建议 这些项目由 SPARK 在竞争的基础上进行审查和资助。这些基于团队的项目提供了动手能力 治疗开发方面的真实经验以及与行业资深人士和专家的直接互动。我们的 项目仔细跟踪学生的研究进展、教师指导和项目有效性，以确保 MPTP 不断发展以实现其教育使命。培养具有影响力的科学领导者和创新者 在美国各地的社区中，我们还制定了招聘和保留战略，以培养 学生多样性，利用斯坦福资源并动员 MPTP 社区。 通过其创新课程以及与 SPARK 和行业的合作，MPTP 将向学生传授 接受过严格的基础科学培训以及对药物发现和开发的了解。我们的毕业生 培训计划将独特地能够将基本发现转化为临床进展，并且它们将很好地 定位于成为学术界、工业界、政府和其他部门的科学领导者。