Topic 393: Integrated Photonic Biosensor for Precision Oncology Dose Measurements

主题 393：用于精密肿瘤剂量测量的集成光子生物传感器

• 批准号: 10227889
• 负责人: Richard Black
• 金额: $ 5.5万
• 依托单位: INTELLIGENT FIBER OPTIC SYSTEMS CORP
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-16 至 2020-12-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10227889
• 关键词: Animals; Biological; Biological Assay; Biosensor; Cancerous; Charge; Detection; Devices; Disease; Dose; Image Enhancement; In Situ; In Vitro; Malignant Neoplasms; Measurement; Medical Device; Methods; Monitor; Nitrogen; Oncologist; Optics; Organ; Oxygen; Patients; Performance; Polymers; Radiation; Radiation Tolerance; Radiation therapy; Semiconductors; Time; Tissues; Universities; base; cancer type; design; imaging capabilities; in situ imaging; in vivo; innovation; meetings; model design; nanoparticle; nanoprobe; novel; particle therapy; photonics; point of care; portability; precision oncology; radiation response; response; sensor

Radiation therapy is a widely used primary treatment for multiple malignancies. However, physical dose measurement is not an effective approach as the biological response of different patients or even different types of cancers are very different for the same physical dose. Moreover, diseased tissue and normal organ radiation sensitivities also vary. Existing medical devices (physical dosimeters) do not satisfy all the metrics for assessing biological response to radiation therapy, especially in a point-of-care manner. IFOS and Stanford University are developing a rapid, portable, easy-to-use and quantitative dose measurement method – comprising a portable handheld sensor and a novel nanoprobe for rapid, real-time in-situ imaging of cancerous tissue. The probe is designed to detect Reactive Oxygen and Nitrogen Species (RONS) generated due to radiation and charge particle therapy. The innovation will provide greatly enhanced imaging capabilities to oncologists in radiation treatment monitoring.

放射治疗是多种恶性肿瘤广泛使用的主要治疗方法，但物理剂量测量却很困难。 这不是一种有效的方法，因为不同患者甚至不同类型癌症的生物反应非常不同 而且，对于相同的物理剂量，病变组织和正常器官的放射敏感性也不同。 现有的医疗设备（物理剂量计）不满足评估辐射生物反应的所有指标 IFOS 和斯坦福大学正在开发一种快速、便携、易于使用的疗法。 定量剂量测量方法 - 包括便携式手持传感器和新型纳米探针，用于快速、 该探针旨在检测活性氧和氮物种。 由于辐射和电荷粒子治疗而产生的（RONS），这项创新将大大增强成像效果。 肿瘤学家在放射治疗监测方面的能力。