Understanding the Cognitive and Neural Consequences of Repetitive Head Impacts

了解重复头部撞击的认知和神经后果

基本信息

批准号：
10228820
负责人：
Hector Arciniega
金额：
$ 8.83万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10228820
关键词：
Address Attention Award Behavioral Brain Brain Concussion Chronic Code Cognitive Cognitive deficits Collaborations Craniocerebral Trauma Data Data Analyses Diffuse Dorsal Electroencephalography Environment Experimental Designs Extramural Activities Functional Magnetic Resonance Imaging Future Goals Grant Hospitals Image Impaired cognition Impairment Individual Injury Intervention Knowledge Learning Learning Skill Maintenance Measures Memory impairment Mentors Methodology Mild Concussions Monitor Neuropsychological Tests Participant Patients Pattern Performance Phase Population Predictive Factor Process Public Health Recording of previous events Recovery Rehabilitation therapy Research Research Assistant Research Personnel Research Project Grants Rest Short-Term Memory Signal Transduction Site Symptoms Technical Expertise Techniques Testing Time TimeLine Training Traumatic Brain Injury Traumatic Brain Injury recovery United States Visit Visual Visuospatial Work base career cognitive change cognitive performance cognitive recovery data analysis pipeline density executive function experimental study follow-up head impact imaging study interest mild traumatic brain injury mind control named group neural network neuromechanism peer performance tests post-doctoral training public health relevance recruit relating to nervous system remediation skill acquisition skills success training opportunity undergraduate research undergraduate student white matter

项目摘要

Project Summary Head injury is a major public health issue. In the United States alone, traumatic brain injury (TBI) causes 235,000 hospital visits, each year. The bulk of these TBI are categorized as mild (concussion; mTBI). It is assumed that after a few months patients gradually return to their premorbid states including the assumption of full cognitive recovery. However, there is a fundamental gap in knowledge as to whether people return to neurotypical levels of performance post-injury, or whether there are lasting cognitive consequences of mTBI. In the current environment, there is no prolonged monitoring and no intervention to track cognitive performance beyond the several week recovery period. This proposal investigates whether people with a history of mTBI return to neurotypical levels of performance on working memory tasks and evaluates neural connectivity to test whether performance is related to neural differences. Working memory is selected as a practical selection because it is an important executive function that could be impacted by a heterogeneous injury such as mTBI. In other words, damage to many parts of the brain could contribute to working memory impairment, thus it would be sensitive to different individual’s mTBI. The populations tested here include chronic mTBI and those in the subacute stage of mTBI recovery. Over both the F99 and K00 phases of the training grant I propose to study both of these mTBI populations using a variety of methodologies to advance my training, including behavioral, HD-EEG, resting state EEG, fMRI, DTI, and neuropsychological tests. In the F99-phase of this proposal (Aim 2), I will gain training in advanced analysis skills and develop additional collaborations with extramural colleagues. I will develop technical skills associated with coding experiments and I will subject data to statistical approaches beyond my current understanding. These skills will allow me to better understand the temporal changes that unfold during cognitive recovery in subacute mTBI. I will also study the cognitive and neural deficits associated with a longer duration since injury in the chronic mTBI population. During the K00- phase of this proposal (Aim 3), I plan on continuing to investigate the extent of enduring cognitive changes associated with mild and moderate TBI. The extension will be to use different neural measures such as resting state fMRI and DTI to assess how neural networks are impacted following injury and which types of changes are more predictive of behavioral performance. The short-term goal of the proposed work is to understand the cognitive and neural consequences associated with mild and moderate forms of TBI. This long-term goal of mine, as a future independent researcher, will be to develop and refine interventions to address cognitive performance in the mTBI and TBI populations. This grant would allow me to make significant progress toward my long-term goal.

项目概要仅在美国，头部损伤就是一个主要的公共卫生问题。每年有 235,000 人次去医院就诊，其中大部分属于轻度脑损伤（脑震荡；mTBI）。假设几个月后患者逐渐恢复到病前状态，包括假设然而，对于人们是否能够恢复认知，目前还存在根本性的认识空白。受伤后的神经典型表现水平，或者 mTBI 是否会产生持久的认知后果。在当前环境下，没有长时间的监测和干预来跟踪认知表现该提案调查了是否有 mTBI 病史的人。返回工作记忆任务的神经典型表现水平并评估神经连接以进行测试性能是否与神经差异相关被选择作为实际选择。因为它是一种重要的执行功能，可能会受到 mTBI 等异质性损伤的影响。换句话说，大脑许多部分的损伤可能会导致工作记忆障碍，因此会对不同个体的 mTBI 敏感。这里测试的人群包括慢性 mTBI 和那些人群。在 mTBI 恢复的亚急性阶段，我建议在培训补助金的 F99 和 K00 阶段。使用各种方法来研究这两个 mTBI 人群来推进我的训练，包括行为、HD-EEG、静息态 EEG、fMRI、DTI 和神经心理学测试。提案（目标 2），我将获得高级分析技能的培训，并与我将培养与编码实验相关的技术技能，并对数据进行研究。超越我目前理解的统计方法将使我更好地理解我还将研究亚急性 mTBI 认知恢复过程中的时间变化。慢性 mTBI 人群中，神经缺陷与损伤后持续时间较长相关。在该提案的阶段（目标 3），我计划继续研究持久认知变化的程度与轻度和中度 TBI 相关的扩展将是使用不同的神经措施，例如休息。状态 fMRI 和 DTI 来评估神经网络在受伤后受到的影响以及哪些类型的变化所提出的工作的短期目标是了解行为表现。与轻度和中度 TBI 相关的认知和神经后果。作为未来的独立研究者，我的目标是开发和完善干预措施来解决认知问题这笔赠款将使我能够在 mTBI 和 TBI 人群中取得重大进展。我的长期目标。