Form-Function Relationships in Femoroacetabular Impingement Syndrome

股骨髋臼撞击综合征的形态与功能关系

基本信息

批准号：
10220713
负责人：
Joseph Mozingo
金额：
$ 6.64万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-17 至 2023-08-16
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10220713
关键词：
3-Dimensional Achievement Address Anatomy Biomechanics Cartilage Clinic Clinical Clinical Treatment Cluster Analysis Collaborations Computational Technique Consensus Control Groups Cross-Sectional Studies Data Decision Making Deformity Degenerative polyarthritis Development Diagnosis Diagnostic Diagnostic radiologic examination Discipline Disease Drops Ensure Etiology Exhibits Fellowship Femur Film Foundations Functional disorder Funding Future General Population Goals Head High Prevalence Hip Osteoarthritis Hip Pain Hip region structure Image Individual Institutes Joints Knowledge Lead Learning Left MRI Scans Magnetic Resonance Imaging Measurement Measures Mechanics Medical Imaging Mentors Mentorship Methods Modeling Morphology Motion Motivation Musculoskeletal Neck Orthopedics Outcomes Research Pain Pathology Patients Pelvis Phenotype Physical therapy Population Positioning Attribute Publications Recording of previous events Reporting Research Research Personnel Risk Running Severity of illness Shapes Slice Structure Subgroup Surface Symptoms Syndrome Techniques Training Universities Utah Walking X-Ray Computed Tomography acetabulum base bone career clinical care cohort educational atmosphere experience improved innovation kinematics multidimensional data pathomechanics research clinical testing scientific computing skills subchondral bone success synergism theories therapy development tool trait

项目摘要

PROJECT SUMMARY/ABSTRACT By some estimates, femoroacetabular impingement syndrome (FAIS) accounts for 82% of hip osteoarthritis cases. Patients present with loss of femoral head sphericity, reduction in femoral-neck offset, and/or an excessively prominent acetabular wall, and report position- or motion-related pain. The theory of FAIS pathophysiology is that pathoanatomy causes pathomechanics. However, quantitative understanding of this disease is lacking. Few investigators have analyzed the relationship between hip anatomy and biomechanics in FAIS patients; those that have relied on 2D measures that incompletely describe hip shape. Based on these 2D shape metrics, ~35% of the general population carries a ‘silent’ form of the disease, which has hindered progress to understand why FAI morphology causes damage. To advance understanding of FAIS pathophysiology, a cross-sectional study of FAIS patients and controls will be performed. Aim 1 will quantify pathomorphology of FAIS. Hip anatomy will be visualized and compared using statistical shape modeling (SSM). Notably, SSM compares shape over the 3D continuum, rather than relative to a single, 2D image. The central hypothesize is that SSM will detect differences in 3D shape of symptomatic and asymptomatic hips; further, this difference will occur whether controls are analyzed together or as anatomic subgroups identified via cluster analysis. Aim 1 will improve clinical understanding of this disease and inform development of better techniques to evaluate hip anatomy. Aim 2 will quantify pathokinematics of FAIS. Hip motion will be measured during functional activities in FAIS patients and controls. The central hypothesis is that hip kinematics will differ between FAIS patients and controls and that significant relationships exist between hip shape and hip kinematics; further, controls with hip shape similar to FAIS patients will have altered kinematics compared to controls that do not. Aim 2 will guide development of treatment options through a better understanding of compensatory mechanisms that occur across groups. The training plan is tailored to facilitate achievement of the applicant’s career goals through development of scientific and professional skills and opportunities to generate and disseminate research findings. The training plan enables collaboration between the applicant and sponsors in the University of Utah Departments of Orthopaedics and Physical Therapy, and Scientific Computing and Imaging Institute. The sponsor team (Drs. Andrew Anderson (primary mentor), Shireen Elhabian, Kenneth “Bo” Foreman, Stephen Aoki) is well-qualified to train the applicant in computational biomechanics, analysis techniques for high-dimensional data, motion analysis, and clinical treatment of hip pathology. The sponsor team has a strong history of successful collaboration, mentorship, publication, and funding. Receipt of an F32 fellowship will enhance synergy between the applicant and sponsors, enable the applicant to take full advantage of the strong research, clinical, and educational environment at the University of Utah, and ensure the applicant success in becoming an independent, impactful researcher.

项目概要/摘要据估计，股骨髋臼撞击综合征 (FAIS) 占髋骨关节炎的 82% 患者表现为股骨头球形度丧失、股骨颈偏移减少和/或股骨颈偏移减少。髋臼壁过度突出，并报告与位置或运动相关的疼痛 FAIS 理论。病理生理学是病理解剖学导致病理力学的原因，但对此的定量理解。很少有研究人员分析髋关节解剖学和生物力学之间的关系。 FAIS 患者；那些依赖于不完全描述髋部形状的 2D 测量的患者。二维形状指标，约 35% 的普通人群携带这种疾病的“沉默”形式，这阻碍了理解为什么 FAI 形态会造成损害的进展促进对 FAIS 的理解。病理生理学，将对 FAIS 患者和对照进行横断面研究，目标 1 将进行量化。 FAIS 的病理形态学将使用统计形状模型进行可视化和比较。 (SSM) 值得注意的是，SSM 比较 3D 连续体上的形状，而不是相对于单个 2D 图像。中央胶囊是SSM将检测有症状和无症状髋部3D形状的差异；此外，这种差异会发生控制是否一起分析或作为识别的解剖亚组通过聚类分析，目标 1 将提高对这种疾病的临床了解并为更好的发展提供信息。目标 2 将测量 FAIS 的病理运动学技术。 FAIS 患者和对照组的功能活动期间的中心假设是髋关节运动学会有所不同。 FAIS 患者和对照组之间存在显着关系，髋部形状和髋部之间存在显着关系此外，与 FAIS 患者相比，髋部形状相似的对照组的运动学也会发生改变。目标 2 将通过更好地了解来指导治疗方案的制定。跨群体的补偿机制培训计划是为了促进实现目标而量身定制的。通过发展科学和专业技能以及机会来实现申请人的职业目标生成并传播研究成果。培训计划使申请人和研究人员之间能够进行合作。犹他大学骨科和物理治疗系以及科学系的赞助商计算与成像研究所。赞助团队（Andrew Anderson 博士（主要导师）、Shireen） Elhabian、Kenneth “Bo” Foreman、Stephen Aoki）非常有资格对申请人进行计算方面的培训生物力学、高维数据分析技术、运动分析、髋关节临床治疗申办者团队有着悠久的成功合作、指导、出版和发展历史。获得 F32 奖学金将增强申请人和赞助商之间的协同作用，使申请人充分利用大学强大的研究、临床和教育环境犹他州，并确保申请人成功成为一名独立、有影响力的研究人员。