Sex and Age Differences in Immunity to Influenza (SADII)

流感免疫力的性别和年龄差异 (SADII)

• 批准号: 10213168
• 负责人: SABRA L. KLEIN
• 金额: $ 163.7万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213168
• 关键词: Address; Adult; Adverse reactions; Affect; Age; Age-Years; Aging; Animal Model; Antiviral Agents; Autoimmune; Avian Influenza; Biological; Biological Aging; Cells; Centers of Research Excellence; Cessation of life; Clinical; Clinical Trials; Collaborations; Communicable Diseases; Community Health; Complex; Data; Development; Disease; Disease Outcome; Female; Gender; Genes; Genetic; Health; Hormonal; Hospitalization; Human; Immune; Immune response; Immunity; Immunologics; Immunology; Infection; Inflammation; Inflammatory; Influenza; Influenza vaccination; Interdisciplinary Study; International; Journals; Leadership; Life Cycle Stages; Longevity; Mediating; Memory; Microbiology; Mission; Pathogenesis; Pathology; Pharmacotherapy; Physicians; Population; Positioning Attribute; Principal Investigator; Productivity; Public Health; Publishing; Recommendation; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Scientist; Sex Bias; Sex Differences; Social outcome; Societies; Specialized Center; Statistical Models; Testing; Time; Translational Research; United States; United States National Institutes of Health; Universities; Ursidae Family; Vaccination; Vaccine Antigen; Vaccines; Women' s Health; age difference; age related; biological sex; career; development policy; experience; frailty; human old age (65+); improved; infectious disease treatment; influenza infection; influenza outbreak; influenza virus vaccine; influenzavirus; male; novel; outcome prediction; pandemic influenza; pathogen; preclinical study; programs; response; seasonal influenza; sex; translational approach; translational research program; translational scientist; treatment response; trend; universal influenza vaccine; vaccination outcome; vaccine efficacy; vaccine-induced immunity; young adult

SEX AND AGE DIFFERENCES IN IMMUNITY TO INFLUENZA (SADII) SUMMARY The NIH Office of Research on Women’s Health (ORWH) should support a Specialized Center of Research Excellence (SCORE) on sex differences in influenza immunity because despite having antivirals and vaccines, influenza remains a significant public health threat, causing approximately 100,000 hospitalizations, 30,000 deaths, and approximately $7 billion in lost productivity in the United States, alone. Sex and age are emerging as two host variables that significantly impact the pathogenesis of influenza virus infection and responses to influenza vaccines. The Sex and Age Differences in Immunity to Influenza (SADII, pronounced sādē) SCORE will leverage the internationally recognized research, resources, and educational opportunities at Johns Hopkins University to transform women’s health and impact the development of and policy decisions about influenza vaccine programs, including universal influenza vaccines. The overarching hypothesis being tested through the SADII SCORE Research Projects is that female-biased vaccine-induced immunity to influenza viruses is age-dependent and reflects both hormonal and genetic differences between the sexes that impact immune responses (i.e., both effector and memory) to influenza vaccine antigens. SADII will bring together investigators focused on 1) seasonal influenza vaccination in an existing age and sex stratified human population; 2) animal models that can test hypotheses and mechanisms of action that are inferred from studies in human populations; and 3) the contributions of age, frailty, sex, and gender to vaccine outcomes using quantitative and qualitative statistical models. By using the combined expertise in our research groups, SADII is uniquely positioned to identify the biological basis behind sex and age differences in immune responses to influenza vaccination and disseminate those findings to the broader research, clinical, and public health communities. The overarching mission of the SADII SCORE will be achieved through the following Specific Aims: 1) To provide leadership and oversight of the SADII SCORE and collaboration with other entities at Johns Hopkins and elsewhere to develop a translational research program focused on sex and age differences in immunology and infectious diseases; 2) To systematically evaluate sex differences in vaccine-induced immune responses across the life course using translational approaches involving human studies and mechanistic animal models; and 3) To meet the career enhancement needs of diverse translational scientists studying sex differences at Johns Hopkins and beyond. We are prepared to transform women’s health, sex, and gender research into a signature initiative at Johns Hopkins and in the fields of microbiology and immunology.

流感免疫力的性别和年龄差异 (SADII) 摘要 美国国立卫生研究院妇女健康研究办公室 (ORWH) 应支持专门研究中心 在流感免疫力的性别差异方面表现出色（得分），因为尽管有抗病毒药物和疫苗， 流感仍然是一个重大的公共卫生威胁，导致约 10 万人住院、3 万人住院 仅在美国，性别和年龄就造成了约 70 亿美元的死亡和生产力损失。 作为两个宿主变量，显着影响流感病毒感染的发病机制和对流感病毒的反应 流感疫苗的性别和年龄差异（SADII，发音为 sādē）评分 将利用约翰斯大学国际公认的研究、资源和教育机会 霍普金斯大学致力于改变女性健康并影响相关领域的发展和政策决定 流感疫苗计划，包括通用流感疫苗 正在测试的总体假设。 通过 SADII SCORE 研究项目得出的结论是，女性偏向的疫苗诱导的流感免疫力 病毒具有年龄依赖性，反映了影响性别的荷尔蒙和遗传差异 对流感疫苗抗原的免疫反应（即效应器和记忆）将汇集在一起​​。 研究人员重点关注 1) 在现有年龄和性别分层的人群中接种季节性流感疫苗 2）可以测试从研究中推断的假设和作用机制的动物模型 在人群中；3) 年龄、虚弱程度、性别和性别对疫苗结果的影响 通过利用我们研究小组的综合专业知识，SADII。 具有独特的优势，可以确定免疫反应中性别和年龄差异背后的生物学基础 流感疫苗接种并将这些发现传播到更广泛的研究、临床和公共卫生领域 SADII SCORE 的总体使命将通过以下具体措施来实现。 目标： 1) 领导和监督 SADII SCORE 以及与其他实体的合作 约翰·霍普金斯大学和其他机构开发了一个专注于性别和年龄差异的转化研究项目 免疫学和传染病；2）系统评估疫苗引起的性别差异 使用涉及人体研究的转化方法来研究整个生命过程中的免疫反应 机械动物模型；3）满足不同转化科学家的职业发展需求 在约翰霍普金斯大学及其他地方研究性别差异我们准备改变女性的健康、性别、 约翰·霍普金斯大学的一项标志性倡议以及微生物学和性别研究领域 免疫学。