Diabetes Endocrinology Research Center

糖尿病内分泌研究中心

基本信息

批准号：
7589808
负责人：
LAWRENCE CHAN
金额：
$ 113.62万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-03-20 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7589808
关键词：
Adipocytes Adipose tissue Aging Area Atherosclerosis Autoimmune Process Basic Science Behavioral Medicine Bioinformatics Biology Biomedical Research Biometry Body Composition Cancer Center Cardiovascular system Cells Cellular biology Child Nutrition Clinical Clinical Protocols Clinical Research Clock protein Cloning Collaborations Commit Complications of Diabetes Mellitus Coupled Defect Desire for food Development Diabetes Mellitus Diabetic Angiopathies Discipline Disease Endocrine Endocrine Surgical Procedures Endocrinology Energy Metabolism Faculty Fatty Liver Fostering Foundations Functional disorder Funding Gene Expression Regulation General Hospitals Genes Genetic Transcription Grant Growth HIV-Associated Lipodystrophy Syndrome Head Homeostasis Institution Insulin Insulin Resistance Insulin-Dependent Diabetes Mellitus Investigation Kidney Knockout Mice Laboratories Leadership Letters Lipids Lipodystrophy Lipolysis Lipoproteins Liver diseases Long-Term Effects Medical center Medicine Metabolic Metabolic Diseases Metabolic syndrome Metabolism Molecular Molecular Genetics Molecular and Cellular Biology Mollies Mus Non-Insulin-Dependent Diabetes Mellitus Nuclear Receptors Nutrient Nutritional Study Obesity Operative Surgical Procedures Oxidative Stress Pathway interactions Patients Phase Phenotype Prospective Studies Proteins Proteomics Protocols documentation Recruitment Activity Regulation Research Research Activity Research Personnel Research Training Role Schools Science Sirtuins Somatostatin Strategic Planning Teaching Hospitals Texas Training Training Programs Translational Research United States United States National Institutes of Health Weight maintenance regimen Work adipocyte biology adipocyte differentiation angiogenesis base blood glucose regulation cardiovascular disorder prevention cardiovascular risk factor career college endocrine pancreas development gene therapy genetic epidemiology hormone metabolism in vivo innovation insight islet lipid biosynthesis mouse model multidisciplinary nonhuman primate novel novel strategies nutrition pediatric department perilipin programs protein metabolism stable isotope steroid hormone synergism transcription factor type I and type II diabetes vector

项目摘要

DESCRIPTION, OVERALL (provided by applicant): We seek to establish a Diabetes Endocrinology Research Center (DERC) at Baylor College of Medicine. The DERC will promote diabetes research among a diverse biomedical research base that spans clinical metabolism and nutrition, type 1 and type 2 diabetes and their macrovascular and microvascular complications, lipid homeostasis, adipose biology and energy metabolism, basic molecular and cellular biology, molecular endocrinology, islet biology and gene therapy. Baylor College of Medicine has an extremely strong ongoing biomedical research base in diabetes/endocrinology that can be categorized into four major areas: [1] clinical diabetes research, [2] basic and translational research, [3] molecular endocrinology, and [4] adipogenesis, with membership representing 10 departments and multiple disciplines. The DERC will foster interactions and facilitate collaboration among diabetes/endocrinology researchers, and entice nondiabetes researchers to commit to diabetes research. It will interact with and strengthen existing Research Centers and NIH Training Programs at Baylor and set up new enrichment programs. With College support, the PI (Dr. Chan) set up a highly successful pilot DERC Pilot & Feasibility (P/F) Program in 2004 and, in the last two years, has used internal College funds to support 4 P/F projects selected from 78 applications (2 each from 44 applications in 2004 and 34 applications in 2006) from 10 departments. The DERC will support diabetes research through the following Research Core Laboratories: Clinical Translational Investigation, Microarray, Biostatistics and Bioinformatics, Proteomics, Gene Vector, Mouse Phenotyping, and Nonhuman Primate (in collaboration with the Southwest Foundation for Biomedical Research in San Antonio), that will support diabetes research of DERC faculty and of P/F projects. The DERC will further broaden the diabetes research base at Baylor College of Medicine, while generating strong synergism with other programs and institutions in the Texas Medical Center and in the greater Southwest United States.

总体描述（由申请人提供）：我们寻求在贝勒医学院建立糖尿病内分泌学研究中心 (DERC)。 DERC将在多元化的生物医学研究基地中促进糖尿病研究，涵盖临床代谢和营养、1型和2型糖尿病及其大血管和微血管并发症、脂质稳态、脂肪生物学和能量代谢、基础分子和细胞生物学、分子内分泌学、胰岛生物学和基因治疗。贝勒医学院在糖尿病/内分泌学方面拥有极其强大的持续生物医学研究基础，可分为四个主要领域：[1] 临床糖尿病研究、[2] 基础和转化研究、[3] 分子内分泌学和 [4]脂肪生成，其成员代表 10 个部门和多个学科。 DERC 将促进糖尿病/内分泌学研究人员之间的互动和合作，并吸引非糖尿病研究人员致力于糖尿病研究。它将与贝勒现有的研究中心和 NIH 培训项目互动并加强，并设立新的丰富项目。在学院的支持下，PI（陈博士）于 2004 年建立了一个非常成功的试点 DERC 试点和可行性 (P/F) 计划，并在过去两年中使用学院内部资金支持选定的 4 个 P/F 项目来自 10 个部门的 78 份申请（2004 年 44 份申请各 2 份，2006 年 34 份申请各 2 份）。 DERC 将通过以下研究核心实验室支持糖尿病研究：临床转化研究、微阵列、生物统计学和生物信息学、蛋白质组学、基因载体、小鼠表型分析和非人类灵长类动物（与圣安东尼奥西南生物医学研究基金会合作），将支持 DERC 教员和 P/F 项目的糖尿病研究。这 DERC 将进一步扩大贝勒医学院的糖尿病研究基础，同时与德克萨斯医学中心和美国大西南部的其他项目和机构产生强大的协同作用。