Continuation of Follow-up of DES-exposed Cohorts

继续对 DES 暴露组进行随访

• 批准号: 7584729
• 金额: $ 28.87万
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7584729
• 关键词: Continuation; Follow; up; DES; exposed

¿ Continue active follow-up of the presently formed Boston cohorts of DES-exposed and unexposed-sons and daughters in collaboration with the other DES research centers and with NCI staff. "Maintain a high participation rate by updating address changes periodically and mailing informational newsletters to cohort members at two different points in time. ¿ Collect new information on covariates and health outcomes during the next five-year period of follow-up. In particular, mail follow-up questionnaires to all cohort members, with different questionnaires for sons, daughters, and grandchildren. Process returned questionnaires for data entry at NCI. Request medical record releases from participants who report key health outcomes and obtain pertinent portions of the medical record for validation of disease. Obtain death certificates for participants who have died. ¿ Initiate and direct specific analyses (e.g., analyses of breast cancer and benign breast disease, breast size, endometriosis, body mass index) of study wide data collected during the contract period and previously. Prepare manuscripts on these findings in collaboration with other DES investigators. Participate actively in the development of reports and manuscripts led by other DES investigators. ¿ Assist in planning new DES research initiatives in collaboration with the other DES investigators and scientific staff at NCI.

¿与其他 DES 研究中心和 NCI 工作人员合作，继续积极跟踪目前形成的波士顿 DES 暴露和未暴露儿子和女儿群体“通过定期更新地址变更和邮寄信息通讯来保持高参与率。队列成员在两个不同的时间点。 ¿在接下来的五年随访期间收集有关协变量和健康结果的新信息，特别是，向所有队列成员邮寄后续调查问卷，并为儿子、女儿和孙子提供不同的调查问卷，处理返回的调查问卷以进行数据输入。要求报告关键健康结果的参与者提供医疗记录，并获取医疗记录的相关部分以验证疾病。 获得已死亡参与者的死亡证明。 ¿与其他 DES 研究人员合作，启动并指导对合同期间和之前收集的研究范围数据进行具体分析（例如，乳腺癌和良性乳腺疾病、乳房大小、子宫内膜异位症、体重指数的分析）。积极参与由其他 DES 研究人员领导的报告和手稿的编写。 ¿与 NCI 的其他 DES 研究人员和科学人员合作，协助规划新的 DES 研究计划。