HISTOCOMPATIBLE PLURIPOTENT STEM CELLS

组织相容性多能干细胞

• 批准号: 7715977
• 负责人: SHOUKHRAT M MITALIPOV
• 金额: $ 1.11万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715977
• 关键词: Cells; Computer Retrieval of Information on Scientific Projects Database; Development; ES Cell Line; Epigenetic Process; Funding; Grant; Institution; Monkeys; Parthenogenesis; Pluripotent Stem Cells; Research; Research Personnel; Resources; Somatic Cell; Source; United States National Institutes of Health; egg; embryonic stem cell; human disease; insight; male; somatic cell nuclear transfer; sperm cell

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main aim of this application is to provide important insights into the epigenetic reprogramming following somatic cell nuclear transfer (SCNT) and deriving histocompatible embryonic stem cells (ESCs) for the treatment of human disease. In the proposed studies, monkey ES cell lines will be derived from somatic cells reprogrammed by somatic cell nuclear transfer using various somatic donor cells or by parthenogenesis (egg activation and development without male-sperm contribution).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该应用的主要目的是为体细胞核移植（SCNT）后的表观遗传重编程和衍生用于治疗人类疾病的组织相容性胚胎干细胞（ESC）提供重要见解。在拟议的研究中，猴 ES 细胞系将​​源自通过使用各种体细胞供体细胞的体细胞核移植或通过单性生殖（卵子活化和发育，没有雄性精子贡献）重新编程的体细胞。