Biobehavior Core

生物行为核心

• 批准号: 7677525
• 负责人: Michael A McDonald
• 金额: $ 7.67万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7677525
• 关键词: Animal Model; Antidepressive Agents; Anxiety; Area; Arts; Behavior; Behavioral; Biochemical; Biochemical Genetics; Biogenic Amines; Cognition; Communities; Complex; Computers; Consultations; Core Facility; Data; Depth; Doctor of Philosophy; Duct (organ) structure; Engineering; Evaluation; Foundations; Funding; Gene Proteins; Genetic; Genomics; Goals; Human Resources; Individual; Investments; Laboratories; Link; Manuals; Mental Depression; Methodology; Methods; Modeling; Molecular; Mouse Strains; Mus; Neurosciences; Neurosciences Research; Partner in relationship; Pennsylvania; Pharmaceutical Preparations; Pharmacology; Phenotype; Physiological; Physiology; Process; Proteomics; Recombinants; Research Infrastructure; Research Personnel; Resources; Rewards; Rodent; Role; Selective Serotonin Reuptake Inhibitor; Serotonin; Signal Transduction; Social Behavior; Social Interaction; Technology; Testing; Time; Training; Universities; Variant; behavior test; biobehavior; drug reinforcement; instrumentation; member; neurobehavioral; neuronal cell body; professor; programs; response; social; somatosensory; tool

The Vanderbilt Conte Center for Neuroscience Research Signaling Networks Supporting Serotonin Transport explores the genetic and biochemical networks sustaining 5HT's complex role in behavior and physiology. The Biobehavior Core will organize instrumentation, methodologies and support staff to support behavioral studies of Conte projects. This core, directed by Dr. Michael McDonald, Assistant Professor of Pharmacology at Vanderbilt, organizes mouse behavioral testing on behalf of Conte Investigators in the areas of 1) sensorimotor and somatosensory responses , 2) cognition, anxiety, social behavior and reward, and 3) depression/SSRI responsivity. Training and technical assistance on computer-controlled, automated tasks as well as manual tasks will be provided to project investigators and their staff by the Core director and Core staff. Dr. McDonald will coordinate and oversee the activities of dedicated support staff. Detailed methods and resources offered by the Core will be available at the Conte website and distributed freely to the scientific community. The Core will take advantage of established and expanded infrastructure linked to the Murine Neurobehavioral Laboratory (MNL) directed by Dr. McDonald for the Center for Molecular Neuroscience. This will permit a modest investment in dedicated support from Dr. McDonald and associated staff to deliver state-of-the art mouse behavioral testing capabilities in support of the Conte projects. The Core will be supported by two staff members, one a Ph.D. level, full-time associate completely supported by institutional funds to provide dedicated support for behavioral testing needs of Conte Investigators. The Core Director and Project Investigators will receive expert consultation from Dr. Irwin Lucki, University of Pennsylvania, who is an expert in biogenic amine signaling in rodent neurobehavioral models and tests to elicit SSRI responsiveness. As none of the Conte Investigators have behavioral testing facilities associatec with their laboratories, these tools, methods and personnel resources will provide critical analytica Opportunities to Conte investigators as they pursue a more integrative evaluation of 5HT gene and protein etworks.

范德比尔特孔戴神经科学研究信号网络支持5-羟色胺 运输探讨了维持5HT在行为中的复杂作用的遗传和生化网络和 生理。 Biobehavior Core将组织仪器，方法和支持人员以支持 孔戴项目的行为研究。这个核心，由迈克尔·麦克唐纳（Michael McDonald）博士，助理教授 范德比尔特（Vanderbilt）的药理学，代表孔戴（Conte）调查人员组织老鼠行为测试 1）感觉运动和体感反应，2）认知，焦虑，社会行为和回报， 3）抑郁/SSRI反应性。对计算机控制，自动化的培训和技术帮助 核心董事和 核心人员。麦当劳博士将协调和监督专门的支持人员的活动。详细的 核心提供的方法和资源将在孔戴网站上可用，并自由分发给 科学界。核心将利用已建立和扩展的基础架构 麦当劳博士为分子中心执导的鼠神经行为实验室（MNL） 神经科学。这将允许对麦当劳博士的专门支持进行适度的投资和关联 员工提供最先进的鼠标行为测试功能，以支持孔戴项目。这 核心将由两名工作人员提供支持，一位是博士学位。级别，全职合伙人完全支持 机构资金为孔戴研究人员的行为测试需求提供专门的支持。核心 董事兼项目调查人员将获得大学的专家咨询。 宾夕法尼亚州，是啮齿动物神经行为模型中生物胺信号传导的专家 引起SSRI响应能力。由于孔戴调查人员都没有行为测试设施Associatec 这些工具，方法和人事资源将借助其实验室，将提供关键的分析 孔戴研究人员对5HT基因和蛋白质进行更整合的评估时的机会 etworks。