Palliative Care Research Cooperative Group (PCRC): Refinement and Expansion

姑息治疗研究合作小组 (PCRC)：细化和扩展

基本信息

批准号：
10207778
负责人：
JEAN S KUTNER
金额：
$ 150.98万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-28 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10207778
关键词：
Address Administrative Coordination Aging Area Award Caregiver research Caregivers Caring Childhood Clinical Research Cohort Studies Collaborations Communities Consultations Data Data Science Development Discipline Distress Economically Deprived Population Economics Enrollment Ensure Fostering Goals Grant Informatics Infrastructure Interdisciplinary Study Intervention Investments Joints Measurement Medical Methodological Studies Methodology Multi-Institutional Clinical Trial Outcome Palliative Care Patient Care Patients Persons Population Population Heterogeneity Procedures Process Productivity Quality of life Research Research Activity Research Personnel Research Support Resources Science Site Standardization Structure Support Groups Therapeutic Time Training Translating Underrepresented Minority advanced disease care seeking clinical research site data repository empowered end of life evidence base improved knowledge translation multi-site trial multiple chronic conditions pragmatic trial prevent psychosocial research study skills statistics success training opportunity

项目摘要

PROJECT SUMMARY/ABSTRACT End of life and palliative care (EOLPC) seeks to enhance quality of life for those with serious illness and their caregivers. The need for and delivery of EOLPC have far exceeded the research that provides evidence of best practices. Small, single-site trials, unrepresentative study cohorts, and studies lacking sufficient rigor hamper provision of high-quality EOLPC. While other fields have advanced their evidence through large, diverse, multi-site trials, EOLPC research has been impeded by an insufficient infrastructure and scientific workforce. The primary goals of this U2C application are to increase the productivity and impact of the Palliative Care Research Cooperative Group (PCRC), its ability to facilitate the conduct of high-quality, effective clinical research, and to expand the number and expertise of palliative care researchers in conducting multi-site clinical trials. The PCRC strives to advance the science of EOLPC by providing investigators with the broad range of support necessary to conduct large scale, multi-site clinical trials and other research studies. This support includes training opportunities, pilot grant awards, access to a large, centralized repository of data from EOLPC studies, methodologic consultation, administrative coordination of research activities, and access to a large network of potential study enrollment sites. Structurally, the PCRC consists of six synergistic components, each led by a senior EOLPC researcher. The Project Coordinating Center coordinates overall administration of the PCRC. The Investigator Development Center builds the skills of EOLPC researchers. Four Cores provide methodological expertise: Data, Informatics, and Statistics; Measurement; Caregiver Research; and Clinical Studies/Methodology. The U2C PCRC application addresses Scientific, Operational, Capacity-building, and Collaborative Aims. By accomplishing these aims, the PCRC will expand its ability to support a robust community of interdisciplinary EOLPC researchers who address topics that guide the delivery of palliative care with an ultimate goal of improving the lives of patients with serious illness and their caregivers.

项目概要/摘要临终关怀和姑息治疗 (EOLPC) 旨在提高患有严重疾病的人及其家人的生活质量照顾者。 EOLPC 的需求和交付远远超出了提供证据的研究最佳实践。小型、单中心试验、不具代表性的研究队列以及缺乏足够严谨性的研究阻碍了高质量 EOLPC 的提供。虽然其他领域已经通过大量的证据提出了证据，由于基础设施和科学条件不足，EOLPC 研究受到多样化、多地点试验的阻碍。劳动力。此 U2C 应用程序的主要目标是提高生产力和影响力姑息治疗研究合作组织 (PCRC)，其有能力促进开展高质量、有效的临床研究，并扩大姑息治疗研究人员的数量和专业知识，以进行多中心临床试验。 PCRC 致力于通过为研究人员提供以下信息来推进 EOLPC 的科学发展：进行大规模、多地点临床试验和其他研究所需的广泛支持。这种支持包括培训机会、试点补助金、访问大型集中式数据存储库来自 EOLPC 研究、方法咨询、研究活动的行政协调和访问一个庞大的潜在学习注册地点网络。在结构上，PCRC 由六个协同组成每个组件均由一位高级 EOLPC 研究员领导。项目协调中心统筹协调 PCRC 的管理。研究者发展中心培养 EOLPC 研究人员的技能。四个核心提供方法论专业知识：数据、信息学和统计；测量;看护者研究;和临床研究/方法学。 U2C PCRC 应用程序涉及科学、操作、能力建设和协作目标。通过实现这些目标，PCRC 将扩大其能力支持强大的跨学科 EOLPC 研究人员社区，他们解决指导交付的主题姑息治疗的最终目标是改善重病患者及其生活照顾者。