Research Training in Cardiovascular and Pulmonary Diseases

心血管和肺部疾病研究培训

• 批准号: 7599568
• 负责人: S. Jamal Mustafa
• 金额: $ 31.36万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7599568
• 关键词: Cardiovascular system; Lung diseases; Research Training

Description (provided by applicant): This predoctoral training grant will support the multidisciplinary research training of graduate students for careers as independent investigators conducting research in cardiovascular and/or pulmonary diseases. Faculty advisors are investigators trained in various disciplines including: Physiology, Pharmacology, Biochemistry, Cell Biology, Neurobiology, Microbiology, Immunology, Exercise Science, Genetics, Molecular Biology, Internal Medicine, Cardiology and Pulmonology. Training faculty also include established scientists at the National Institute for Occupational Safety & Health (NIOSH), known for its research on inflammation and lung diseases. NIOSH is a research division of the CDC immediately adjacent to the School of Medicine. Most training faculty are members of either the (1) Center for Cardiovascular Research or (2) Center for Respiratory Biology & Lung Disease Research. The initial period of predoctoral training will emphasize courses which include Cell Biology, Biochemistry, Physiology, Molecular Biology, Statistics and Genomic Sciences as well as training in Scientific Integrity & Ethics. This first year of graduate work is organized as an integrated, core curriculum coupled with advanced literature-based graduate elective modules in the 2nd semester, which provides a solid foundation for advanced graduate courses and research. Students select a doctoral dissertation advisor by the end of their first year, based on laboratory research rotations. Thereafter, students pursue research under the supervision of their mentor, in addition to taking selective advanced graduate courses, attending seminars, participating in journal clubs, writing their PhD thesis proposals and presenting data at national meetings. Areas of research training include endothelial cell biology, inflammation induced vascular injury, microvascular physiology, cardiac pathobiology, airway and vascular reactivity, lung epithelial pathology, vascular smooth muscle biology, gene expression and lipids, ischemia-reperfusion, reactive oxygen radicals, cell signaling pathways, vascular remodeling, and angiogenesis, to name a few. Disease relevance of trainee projects are numerous; eg. coronary ischemia, asthma, pulmonary edema, hypertension, cardiac failure, intestinal vascular inflammation, pulmonary fibrosis, peripheral vascular disease, etc. Our interactive research environment, enhanced by Interdisciplinary Research Centers provides an ideal setting for cross fertilization of ideas, constructive criticism, and training of both Ph.D., and M.D./Ph.D. students for careers as investigators.

描述（由申请人提供）：这笔博士前培训补助金将支持研究生作为独立研究者进行心血管和/或肺部疾病研究的多学科研究培训。教师顾问是受过各种学科培训的研究人员，包括：生理学、药理学、生物化学、细胞生物学、神经生物学、微生物学、免疫学、运动科学、遗传学、分子生物学、内科医学、心脏病学和肺病学。培训教师还包括美国国家职业安全与健康研究所 (NIOSH) 的知名科学家，该研究所以其炎症和肺部疾病研究而闻名。 NIOSH 是 CDC 的一个研究部门，紧邻医学院。大多数培训教师都是 (1) 心血管研究中心或 (2) 呼吸生物学和肺部疾病研究中心的成员。博士前培训初期将侧重于细胞生物学、生物化学、生理学、分子生物学、统计学和基因组科学等课程以及科学诚信和道德方面的培训。第一年的研究生工作被组织为一个综合的核心课程，加上第二学期基于文学的高级研究生选修模块，这为高级研究生课程和研究提供了坚实的基础。学生在第一年结束时根据实验室研究轮换选择一名博士论文导师。此后，学生在导师的监督下进行研究，此外还参加选择性的高级研究生课程、参加研讨会、参加期刊俱乐部、撰写博士论文提案并在全国会议上展示数据。研究培训领域包括内皮细胞生物学、炎症引起的血管损伤、微血管生理学、心脏病理学、气道和血管反应性、肺上皮病理学、血管平滑肌生物学、基因表达和脂质、缺血再灌注、活性氧自由基、细胞信号传导途径、血管重塑和血管生成等等。实习生项目与疾病的相关性很多；例如。冠状动脉缺血、哮喘、肺水肿、高血压、心力衰竭、肠道血管炎症、肺纤维化、周围血管疾病等。我们的互动研究环境，在跨学科研究中心的推动下，为思想的交叉传播、建设性的批评和研究提供了理想的环境。博士和医学博士/博士的培训从事调查员职业的学生。