Developmental and peer effects on the neurobiology of cognitive control and reward processes

认知控制和奖励过程的神经生物学的发展和同伴效应

基本信息

批准号：
10204863
负责人：
BRIAN M HICKS
金额：
$ 49.4万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10204863
关键词：
12 year old 15 year old 18 year old 20 year old Adolescence Adolescent Adult Affect Affective Age Alcohol abuse Alcohol consumption Alcohols Behavioral Brain Clinic Coitus Consumption Cues Data Development Drug usage Ensure Exhibits Feedback Functional Magnetic Resonance Imaging Impairment Intake Joints Lead Lifestyle-related condition Link Longitudinal Studies Longitudinal cohort Measures Mental Health Modeling Motivation Neurobiology Neurologic Process Patients Pattern Pharmaceutical Preparations Process Protocols documentation Psychiatry Psychopathology Research Rewards Risk Risk-Taking Role Sampling Shapes Signal Transduction Social Interaction Stimulus Time adolescent alcohol risk adolescent substance use alcohol risk base cognitive control cohort comorbidity design deviant peer drug use behavior early alcohol use early onset substance use emerging adult financial incentive follow up assessment functional MRI scan high reward high risk longitudinal design network models neurobehavioral neurophysiology peer peer influence preadolescence psychosocial recruit relating to nervous system reward anticipation social substance use underage drinking young adult

项目摘要

Abstract Alcohol and drug use problems that onset in adolescence are associated with a more severe and persistent course and impairments in multiple domains of psychosocial functioning. A key predictor of loss of control of substance use is the difference in activation between the reward and cognitive control networks. Specifically, the greater the activation of the reward network to drug cues relative to that of the control network, the less control over drug use behavior. During adolescence, maturation of the reward network outpaces that of the control network, resulting in a bias toward risk-taking when in the presence of reward cues. In adolescents but not adults, the presence of peers has been shown to increase risk-taking due to greater activation of the reward network. Adolescents spend more time with peers than adults and deviant peer affiliation is the strongest correlate of alcohol and drug use problems, and drinking alcohol is an especially social activity shared with peers. The combination of these neurodevelopmental and peer influences on the reward network then may be key neurobiological and contextual mechanisms that account for the large increases in alcohol and drug use problems during adolescence. We will examine the development of the neurobiological processes of the reward and cognitive control networks, peer effects on these networks, and how these neurobiological and contextual processes contribute to risk-taking and alcohol and drug use problems in adolescence using a longitudinal fMRI study. We will use an accelerated longitudinal cohort design that covers pre- (10-12 years-old), middle (13-15 years-old), and later (16-18 years-old) adolescence (total N=210), with 1-year and 2-year follow-up assessments. This design will allow us to cover 10 years (10 to 20 years-old) of neurobiological development in half the time. Our protocol will include an assessment of peer presence on reward activation during risking-taking (stoplight task) and reward anticipation and receipt (monetary incentive delay); neurological processes associated with explicit social feedback in the form of acceptance and rejection (chatroom social interaction task); and a basic cognitive control task (stop signal) to assess inhibitory processes. We predict that peer presence will increase reward activation during risk taking and reward receipt, and that these peer effects on reward activation will increase from pre- to middle adolescence. Further, greater reward reactivity and weaker cognitive control will be associated with greater sensitivity to peer influences. Finally, greater reward reactivity, weaker cognitive control, and greater sensitivity to both peer presence and explicit social feedback will be associated with greater alcohol and drug use problems and comorbid externalizing and internalizing problems.

抽象的青春期出现的酗酒和吸毒问题与更严重和更严重的问题有关。心理社会功能多个领域的持续过程和损伤。损失的一个关键预测因素物质使用的控制是奖励和认知控制网络之间激活的差异。具体来说，相对于控制网络，奖励网络对药物线索的激活越大，对吸毒行为的控制越少。在青春期，奖励网络的成熟速度超过了控制网络的影响，导致在存在奖励线索时倾向于冒险。在事实证明，在青少年而非成年人中，同龄人的存在会增加冒险行为，因为同伴的存在会增加冒险行为。奖励网络的激活。青少年比成年人和异常同龄人花更多的时间与同龄人相处隶属关系是酒精和吸毒问题之间最强的相关性，而饮酒是一个特别重要的因素。与同龄人分享的社交活动。这些神经发育和同伴影响的结合对那么奖励网络可能是关键的神经生物学和情境机制，解释了大青春期期间酗酒和吸毒问题增加。我们将研究奖励和认知控制的神经生物学过程的发展网络、同伴对这些网络的影响，以及这些神经生物学和情境过程如何做出贡献使用纵向功能磁共振成像研究来了解青春期的冒险以及酗酒和吸毒问题。我们将使用加速纵向队列设计，涵盖前期（10-12岁）、中期（13-15岁）和后来（16-18岁）青春期（总N=210），进行1年和2年的随访评估。这个设计将使我们能够用一半的时间涵盖 10 年（10 至 20 岁）的神经生物学发育。我们的协议将包括对冒险期间奖励激活的同伴存在进行评估（红绿灯任务）奖励预期和接收（金钱奖励延迟）；与外显相关的神经过程接受和拒绝形式的社会反馈（聊天室社交互动任务）；和一个基本的认知控制任务（停止信号）来评估抑制过程。我们预测同行的存在将会增加在冒险和获得奖励期间奖励激活，并且这些同伴对奖励激活的影响将从青春期前到中期增加。此外，更大的奖励反应和更弱的认知控制将对同伴影响更加敏感。最后，奖励反应性更强，认知能力更弱控制，以及对同伴存在和明确的社会反馈的更大敏感性将与更严重的酗酒和吸毒问题以及共病的外化和内化问题。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Who bought a gun during the COVID-19 pandemic in the United States?: Associations with QAnon beliefs, right-wing political attitudes, intimate partner violence, antisocial behavior, suicidality, and mental health and substance use problems.

谁在美国 COVID-19 大流行期间买了枪？：与 QAnon 信仰、右翼政治态度、亲密伴侣暴力、反社会行为、自杀以及心理健康和药物使用问题相关。

DOI：
发表时间：
2023
期刊：
影响因子：
3.7
作者：
Hicks, Brian M;Vitro, Catherine;Johnson, Elizabeth;Sherman, Carter;Heitzeg, Mary M;Durbin, C Emily;Verona, Edelyn
通讯作者：
Verona, Edelyn