SLEEP: THE EFFECT ON APPETITE AND CARBOHYDRATE METABOLISM

睡眠：对食欲和碳水化合物代谢的影响

• 批准号: 7604777
• 负责人: Silvana Pannain
• 金额: $ 0.62万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604777
• 关键词: Affect; Carbohydrates; Computer Retrieval of Information on Scientific Projects Database; Desire for food; Fatigue; Food; Funding; Glucose; Grant; Hormones; Hour; Hunger; Institution; Insulin; Measures; Moods; Obesity; Performance; Polysomnography; Psyche structure; Purpose; Recording of previous events; Recruitment Activity; Research; Research Personnel; Resources; Restless Legs Syndrome; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Source; Study Subject; Time; United States National Institutes of Health; carbohydrate metabolism; day

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Daytime sleepiness and fatigue are frequent complaints of obese subjects. Previous studies done in our lab have shown that sleep restriction increases subjects appetite for high carbohydrate foods, and decreases levels of hormones that suppress appetite. The purpose of this study is to examine the effects of sleep on levels of glucose and hormones that affect appetite. The effects of sleep on mood, mental performance, and daytime sleepiness are also examined. All subjects recruited are morbidly obese (BMI > 40), and have no history of sleep disorders (sleep apnea, restless leg syndrome). The study consists of a 10 day stay in the sleep research center and GCRC. The first three nights of the study, the subjects sleep at their regular bedtimes (pre-determined by an activity monitor and sleep log). The following seven nights, subjects have their sleep extended by three hours (1.5 hours earlier at bedtime, and 1.5 hours later at wake time). Daytime sleepiness, hormones controlling hunger, insulin, glucose levels, and subjective measures of sleepiness, mood, vigor, hunger, and appetite are measured pre-extension and post-extension.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 白天嗜睡和疲劳经常对肥胖受试者抱怨。 先前在实验室进行的研究表明，睡眠限制会增加对高碳水化合物食物的食欲，并降低抑制食欲的激素水平。 这项研究的目的是检查睡眠对影响食欲的葡萄糖和激素水平的影响。还检查了睡眠对情绪，心理表现和白天嗜睡的影响。 招募的所有受试者均为病态肥胖（BMI> 40），没有睡眠障碍史（睡眠呼吸暂停，不安的腿综合症）。 该研究包括在睡眠研究中心和GCRC中停留10天。 研究的前三个晚上，受试者在常规的床位时睡觉（通过活动监护仪和睡眠日志预定）。 在接下来的七个晚上，受试者的睡眠延长了三个小时（睡前1.5小时，在唤醒时间1.5小时）。 白天的嗜睡，控制饥饿，胰岛素，葡萄糖水平以及嗜睡，情绪，活力，饥饿和食欲的主观度量的荷尔蒙均可测量和延伸后。