Training Program in Personalized Cardiovascular Medicine (TPIPCVM)

个性化心血管医学培训计划 (TPIPCVM)

• 批准号: 10204788
• 负责人: Dawood Darbar
• 金额: $ 49.28万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10204788
• 关键词: Cardiovascular system; Medicine; Training Programs

TRAINING IN PERSONALIZED CARDIOVASCULAR MEDICINE (TPIPCVM) Project Summary Cardiovascular disease (CVD) remains a major cause for significant morbidity and mortality in the U.S. especially in ethnic minorities with their high burden of risk factors. Personalized medicine is a rapidly growing field of healthcare whereby an individual's unique genomic, environmental and clinical background is analyzed to ascertain susceptibility to disease, predict their clinical course and tailor specific therapies. Despite recent advances in CV genomics, our inability to target therapy to underlying mechanisms in individual patients, the failure to translate these scientific discoveries to the bedside care of patients and barriers to the incorporation of ethnic minorities in translational CV research have limited our ability to fulfill the promise of personalized medicine. Furthermore, traditional training programs are no longer able to provide trainees with the requisite skills needed to implement the personalized medicine revolution underway. Thereby, major goals of the Training Program in Personalized Cardiovascular Medicine (TPIPCVM) are to equip trainees to become leaders in CV Genomics and be trained in molecular, cellular, disease and whole animal modeling and clinical and translational approaches to CVD so that this new knowledge can be translated into best evidence-based personalized CV care. We will recruit highly talented and motivated pre- and post-doctoral trainees and provide them with the highest caliber training in CV genomics stemming from existing strengths of our faculty in the Division of Cardiology and our partners at UIC. The 3 Research Focus Groups: 1) Cardiac arrhythmias; 2) Ischemic and non-ischemic cardiomyopathy; and CVD-related metabolic syndrome are highly interrelated with each other and directly linked with the central theme of Personalized CV Genomics. The overarching goal of the TPIPCVM is to train the next generation of CV investigators to create new knowledge and implement into best evidence-based personalized medicine. The TPIPCVM mentors are highly successful physician-scientists/scientists with a proven record of research, mentoring and collaboration who offer superb inter- and multi- disciplinary training opportunities. Major strengths of this training program include: exposure of trainees to an integrated basic science molecular, cellular, and whole patient approach to identify the underlying mechanisms of CVD; the track record of the faculty and their common research interest in Personalized CV Genomics; dedicated training in personalized CV medicine; and the potential to implement scientific discoveries to a diverse and under-represented population of patients cared for at UIC Medical Center. The TPIPCVM sets out to train 2 pre-doctoral and 2 post-doctoral students annually. Collectively, this Training Program offers a unique training experience and fulfills an urgent need for training in personalized CV medicine.

个性化心血管医学培训 (TPIPCVM) 项目概要 心血管疾病（CVD）仍然是导致显着发病率和死亡率的主要原因 美国尤其是少数族裔，他们的风险因素负担很高。个体化医疗是 快速发展的医疗保健领域，个人独特的基因组、环境和临床 分析背景以确定对疾病的易感性，预测其临床病程并进行定制 具体疗法。尽管CV基因组学最近取得了进展，但我们仍无法针对疾病进行靶向治疗 个别患者的潜在机制，未能将这些科学发现转化为 患者的床边护理以及将少数民族纳入翻译简历的障碍 研究限制了我们实现个性化医疗承诺的能力。此外， 传统的培训计划不再能够为学员提供必要的技能 实施正在进行的个性化医疗革命。因此，培训的主要目标 个性化心血管医学计划（TPIPCVM）旨在使学员成为 CV Genomics 领域的领导者并接受分子、细胞、疾病和整体动物建模方面的培训 以及 CVD 的临床和转化方法，以便将这些新知识转化为 最佳循证个性化简历护理。我们将招募才华横溢、积极进取的预科和 博士后学员，并为他们提供CV基因组学干细胞提取方面最高水平的培训 得益于我们心脏病学系的教员和伊利诺伊大学芝加哥分校 (UIC) 合作伙伴的现有优势。 3号 研究焦点小组：1）心律失常； 2）缺血性和非缺血性心肌病；和 CVD相关代谢综合征彼此高度相关，并与心血管疾病直接相关。 个性化简历基因组学的中心主题。 TPIPCVM 的总体目标是训练 下一代简历调查员创造新知识并实施最佳的基于证据的 个性化医疗。 TPIPCVM 导师是非常成功的医师科学家/科学家 拥有良好的研究、指导和合作记录，提供卓越的内部和多边合作 纪律培训机会。该培训计划的主要优势包括： 学员将接受综合基础科学分子、细胞和整个患者的方法来识别 CVD的潜在机制；教师的业绩记录及其共同的研究兴趣 个性化简历基因组学；个性化心血管医学专门培训；以及潜力 将科学发现应用于接受护理的多样化且代表性不足的患者群体 UIC医疗中心。 TPIPCVM拟培养2名博士前学生和2名博士后 每年。总的来说，该培训计划提供了独特的培训体验并满足了紧急需求 需要个性化心血管医学培训。