ISOLATION & CHARACTERIZATION OF CARDIOACTIVE COMPOUNDS IN HI BOX JELLYFISH VENOM

隔离

• 批准号: 7720348
• 负责人: ANGEL ANNE YANAGIHARA
• 金额: $ 3.75万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720348
• 关键词: Accident and Emergency department; Astacoidea; Australia; Biochemical; Cardiac; Cardiopulmonary; Caring; Carybdea; Class; Clinical; Clinical Management; Computer Retrieval of Information on Scientific Projects Database; Cubozoa; Distress; Funding; Goals; Grant; Hawaii; Hawaiian population; Indonesia; Insecta; Institution; Jellyfish; Life; Mus; Pain; Patients; Physiological; Research; Research Personnel; Research Proposals; Resources; Signs and Symptoms; Source; Sting Injury; Syndrome; Toxin; United States National Institutes of Health; Venoms; Water; base; insight; small molecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hawaiian box jellyfish (Carybdea alata) belong to the most notoriously toxic class of jellyfish, the cubozoans, which are commonly found in tropical and subtropical waters from Hawaii to Australia. Cubozoan stings are extremely painful and result in potentially life-threatening Irukandji syndrome, which presents as a constellation of systemic signs and symptoms, including cardiopulmonary distress. A retrospective clinical analysis of emergency room patients demonstrates that Irukandji syndrome occurs in about 5% of local box jellyfish sting victims. Still, the precise biochemical basis for this syndrome is unclear. In Hawaii, Australia and Indonesia, current therapy is limited to symptomatic care. This research proposal is prompted by our recent discovery of small molecules, chemically similarly to certain insect toxins, which induce multiple physiological effects including profound cardiac effects in both crayfish and mice. The specific aims of this project are to conduct focused efforts to purify, identify and physiologically characterize these highly cardioactive compounds. The overall goal is to provide much-needed insights into the mechanisms of action of these compounds and provide the basis for better clinical management.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 夏威夷盒子水母（Carybdea alata）属于最臭名昭著的毒性水母，Cubozoans，通常在从夏威夷到澳大利亚的热带和亚热带水域中发现。 Cubozoan的刺痛极为痛苦，会导致潜在的威胁生命的Irukandji综合征，该综合症是全身体征和症状的星座，包括心肺痛苦。 急诊室患者的回顾性临床分析表明，Irukandji综合征发生在约5％的当地盒子水母刺激受害者中。 尽管如此，该综合征的精确生化基础尚不清楚。 在夏威夷，澳大利亚和印度尼西亚，当前的治疗仅限于有症状护理。 我们最近发现的小分子在化学上与某些昆虫毒素相似，该研究促使这项研究提示引起了多种生理作用，包括小龙虾和小鼠的深刻心脏影响。该项目的具体目的是努力纯化，识别和生理表征这些高度的心活性化合物。 总体目标是为这些化合物的作用机理提供急需的见解，并为更好的临床管理提供了基础。