CHRONIC PERIODONTITIS

慢性牙周炎

• 批准号: 7725320
• 负责人: LYNNAE Karen MILLAR Sauvage
• 金额: $ 1.78万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725320
• 关键词: Affect; Antibody Formation; Asians; Birth; Blood Glucose; Case-Control Studies; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Development; Diabetic mother; Funding; Gestational Age; Gestational Diabetes; Grant; Healthcare; Hyperbilirubinemia; Hypoglycemia; Institution; Metabolic; Neonatal; Organism; Outcome; Oxidative Stress; Pacific Island Americans; Periodontal Diseases; Periodontal Infection; Periodontitis; Pilot Projects; Population; Pregnancy; Pregnant Women; Premature Birth; Rate; Research; Research Personnel; Resources; Risk; Risk Factors; Source; United States National Institutes of Health; Week; Woman; diabetic; disability; maternal stress; modifiable risk; non-diabetic; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize the development of gestational diabetes (GDM) during pregnancy results in oxidative stress, with an associated impaired antibody response, ultimately resulting in the development or progression of periodontal disease. GDM is important clinically, as adverse neonatal outcomes have been associated with this condition. Adverse outcomes include neonatal macrosomia, hypoglycemia, hyperbilirubinemia and metabolic disturbances. Millions of health care dollars are spent each year attempting to optimize maternal blood sugar control, to prevent these adverse outcomes. An understanding of the mechanisms leading to the development of GDM would be of tremendous benefit. Periodontal disease is likely to be a contributing factor to the high rate of premature birth in diabetic women, and is a potentially modifiable risk factor contributing to the ethnic disparities in the rate of preterm delivery in this Asian and Pacific Islander (API) population. Preterm delivery is a major healthcare problem affecting one in ten births and is the leading cause of neonatal death and long term disability. We will determine organisms involved in periodontal disease in diabetic and non-diabetic pregnant women from this pilot study. This case control study will enable us to obtain preliminary data on the maternal stress and antibody response to periodontal infection in GDM and non-diabetic mothers. This will enable us to proceed with our RO1 application where in addition to studying the relationship between GDM and periodontal disease, we will determine if periodontal disease increases the risk of preterm birth (gestational age less than 37 weeks) in our population of API women.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们假设怀孕期间妊娠糖尿病（GDM）的发展导致氧化应激，并与抗体反应相关，最终导致牙周疾病的发展或进展。 GDM在临床上很重要，因为不良新生儿结局与这种情况有关。 不良后果包括新生儿巨症，低血糖，高胆红素血症和代谢障碍。 每年都花费数百万的保健资金来试图优化孕产妇的血糖控制，以防止这些不良结果。 对导致GDM发展的机制的理解将带来巨大的好处。 牙周疾病可能是糖尿病女性过早出生率的促成因素，并且是可能改变的危险因素，导致该亚洲和太平洋岛民（API）人口的早产率的种族差异。 早产是一个主要的医疗问题，影响了十分之十的生育，这是新生儿死亡和长期残疾的主要原因。 我们将从这项试点研究中确定糖尿病和非糖尿病孕妇牙周疾病涉及的生物。 该病例控制研究将使我们能够获得有关GDM和非糖尿病母亲牙周感染的母体应力和抗体反应的初步数据。 这将使我们能够继续进行RO1应用，除了研究GDM与牙周疾病之间的关系外，我们还将确定我们的API女性人群中牙周疾病是否增加了早产的风险（胎龄小于37周）。