The prevalence of diagnosed and undiagnosed Alzheimer's disease and related dementias among Arab Americans

阿拉伯裔美国人中已诊断和未诊断的阿尔茨海默病及相关痴呆症的患病率

基本信息

批准号：
10362682
负责人：
Tiffany Billmeier Kindratt
金额：
$ 7.7万
依托单位：
UNIVERSITY OF TEXAS ARLINGTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-15 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10362682
关键词：
Address Adult Advocate Affect Age Aging Alzheimer&apos s disease diagnosis Alzheimer&apos s disease related dementia American Arabs Asian population Attention Birth Place Black Populations Caribbean Hispanic Classification Code Cognitive Community Surveys Complement Data Data Set Data Sources Development Diabetes Mellitus Diagnosis Discrimination Ethnic Origin Ethnic group Europe Expenditure Federal Government Fibrinogen Fostering Health Health Surveys Hispanic Populations Household ICD-9 Immigrant Individual International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10)Intervention Knowledge Link Literature Logistic Regressions Measures Medical Mental Depression Methods Mexican Americans Middle East Minority Groups Mission Modeling National Health Interview Survey National Institute on Aging Northern Africa Not Hispanic or Latino Outcome Patient Self-Report Persons Policies Population Prevalence Procedures Provider Psyche structure Public Health Race Reporting Research Research Personnel Resources Sampling Scientist Surveys System United States Agency for Healthcare Research and Quality Vulnerable Populations Work base cognitive disability dementia risk disability epidemiology study ethnic minority population experience improved innovation racial and ethnic racial and ethnic disparities racial minority response sex social

项目摘要

PROJECT SUMMARY/ABSTRACT The national prevalence of diagnosed and undiagnosed Alzheimer’s disease and related dementias (ADRD) among Arab Americans is unknown. Estimates are unknown because Arab Americans are considered non- Hispanic (NH) whites in national health surveys. By using innovative methods to link National Health Interview Survey (NHIS) and Medical Expenditure Panel Survey (MEPS) data, we can disaggregate Arab Americans from the NH white classification to uncover ADRD estimates. Specific aims are to: 1) estimate the age- and sex-adjusted prevalence of diagnosed ADRD among foreign-born Arab Americans compared to US-born NH whites and foreign-born NH whites, NH blacks, NH Asians and Hispanics; 2) examine associations between race, ethnicity and nativity status and the prevalence of diagnosed ADRD before and after controlling for covariates; 3) estimate the age- and sex-adjusted prevalence of undiagnosed ADRD among Arab Americans compared to the aforementioned groups; and 4) examine associations between race, ethnicity and nativity status and the prevalence of undiagnosed ADRD before and after controlling for covariates. Secondary, cross-sectional data from 2000-2016 NHIS and 2001-2017 MEPS data sources will be combined and analyzed. Responses will be matched, and a linked dataset will be created by the Agency for Healthcare Research and Quality. The sample will include adults >45 years. The independent variable will be created by combining questions assessing race, ethnicity and nativity status from NHIS. Foreign-born Arab Americans will be compared to US-born NH whites and foreign-born NH whites, NH blacks, NH Asians and Hispanics. For Aims 1 and 2, the dependent variable is diagnosed ADRD, measured using data from MEPS medical condition files. Adults with ICD-9 codes 290, 294, 331, 797 (2001-2015) or ICD-10 codes F03 or G30 (2016-2017) will be classified as has having diagnosed ADRD. For Aims 3 and 4, the dependent variable is undiagnosed ADRD, measured using MEPS medical condition and household component files. The MEPS asks three questions to estimate cognitive limitations, an indicator of ADRD. Adults will be categorized as having undiagnosed ADRD if: 1) they responded “yes” to one or more questions on cognitive limitations and 2) do not have diagnosed ADRD. Age and sex adjusted prevalence of diagnosed ADRD (Aim 1) and undiagnosed ADRD (Aim 3) will be calculated for Arab Americans compared to US-born NH whites and foreign-born NH whites, blacks, Hispanics and Asians. Logistic regression will be used to determine associations between the combined race, ethnicity and nativity status variable and diagnosed ADRD (Aim 2), and undiagnosed ADRD (Aim 4) before and after controlling for covariates. The innovative method used in this study will contribute the first estimates of diagnosed and undiagnosed ADRD among Arab Americans to the medical literature. Results will help to facilitate policy decisions and advocate for resources to be allocated for interventions to improve the health of this underrepresented but increasingly visible vulnerable population.

项目概要/摘要全国已确诊和未确诊的阿尔茨海默病及相关痴呆症 (ADRD) 的患病率阿拉伯裔美国人的比例未知，因为阿拉伯裔美国人被认为是非阿拉伯裔美国人。国家健康调查中的西班牙裔 (NH) 白人通过使用创新方法将国家健康访谈联系起来。调查（NHIS）和医疗支出小组调查（MEPS）数据，我们可以对阿拉伯裔美国人进行分类根据 NH 白人分类来揭示 ADRD 估计值，具体目标是：1) 估计年龄和年龄。与美国出生的 NH 相比，外国出生的阿拉伯裔美国人中经性别调整的 ADRD 诊断患病率白人和外国出生的新罕布什尔州白人、新罕布什尔州黑人、新罕布什尔州亚洲人和西班牙裔人之间的关联；种族、族裔和出生状况以及控制前后 ADRD 诊断患病率协变量；3) 估计阿拉伯裔美国人中未诊断 ADRD 的年龄和性别调整患病率与上述群体进行比较；4) 检查种族、民族和出生地之间的关联控制协变量之前和之后未诊断 ADRD 的状态和患病率。 2000-2016 年 NHIS 和 2001-2017 年 MEPS 数据源的横截面数据将合并并将对响应进行匹配，并由医疗保健机构创建链接的数据集。研究和质量。样本将包括 45 岁以上的成年人。结合来自 NHIS 的评估种族、民族和出生状况的问题。美国人将与美国出生的新罕布什尔州白人、外国出生的新罕布什尔州白人、新罕布什尔州黑人、新罕布什尔州亚裔和对于目标 1 和 2，因变量被诊断为 ADRD，使用来自的数据进行测量。 MEPS 医疗状况档案 ICD-9 代码 290、294、331、797 (2001-2015) 或 ICD-10 代码 F03 或 G30 (2016-2017) 将被归类为已诊断出 ADRD 的家属。变量是未诊断的 ADRD，使用 MEPS 医疗状况和家庭组成部分进行测量 MEPS 提出三个问题来评估认知限制，这是 ADRD 的一个指标。如果满足以下条件，则被归类为未诊断的 ADRD：1) 他们对一个或多个认知问题回答“是” 局限性；2) 未诊断出 ADRD。经年龄和性别调整后诊断出 ADRD 的患病率（目标 1）和未诊断的 ADRD（目标 3）将针对阿拉伯裔美国人与美国出生的新罕布什尔州白人和外国出生的新罕布什尔州白人、黑人、西班牙裔和亚洲人将用于确定。种族、民族和出生状态变量与诊断出的 ADRD 之间的关联（目标 2），以及控制协变量之前和之后未诊断的 ADRD（目标 4）。研究将首次估计阿拉伯裔美国人中已诊断和未诊断的 ADRD 医学文献的结果将有助于促进政策决策并倡导为之分配资源。旨在改善这一代表性不足但日益明显的弱势群体的健康的干预措施。