University of Florida Chemosensory Clinical Research Program
佛罗里达大学化学感应临床研究项目
基本信息
- 批准号:7671411
- 负责人:
- 金额:$ 56.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-20 至 2011-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAlcohol consumptionAreaArtsBiometryCardiovascular DiseasesClinicClinicalClinical Assessment ToolClinical ResearchCollaborationsDataData CollectionDietDiseaseEnvironmentEsthesiaFacultyFeasibility StudiesFloridaFoodFoundationsFunctional disorderFundingFutureGenesGeneticGenetic PolymorphismGenotypeGoalsGoldHealthHealth Insurance Portability and Accountability ActHealth Services AccessibilityHumanHuman ResourcesIndividualInstitutesInstitutionInternationalLigandsMalignant NeoplasmsMarketingMethodologyMethodsObesityPatientsPerformancePhasePhenotypePilot ProjectsProceduresPropertyProtocols documentationPsychophysicsPsychophysiologyRecruitment ActivityResearchResearch Ethics CommitteesResearch InfrastructureResearch PersonnelResearch Project GrantsRisk FactorsRunningSchemeSecureSensoryServicesSingle Nucleotide PolymorphismSmell PerceptionSmokingSpeedSystemTNFRSF5 geneTaste PerceptionTechnologyTestingTimeUniversitiesVariantcostdata managementdata sharingdesignexperiencehedonicmeetingsmulticore processornovelpatient populationprogramsprototypereceptor bindingsoftware systemssuccessuser-friendlyvirtualvolunteer
项目摘要
DESCRIPTION (provided by applicant): Support is requested to establish the feasibility of and then implement four infrastructural components for the expanding Chemosensory Clinical Research Program of the University of Florida's Center for Smell and Taste. The Program focuses on the clinically important, emerging relationship between chemosensory dysfunction (taste, retronasal olfaction) and health. Variation in chemosensation (genetic or pathological) affects the sensory properties of foods as well as the sensations associated with smoking and alcohol intake. Diet, smoking, and alcohol intake are risk factors for a variety of disorders including obesity, cardiovascular disease, and some cancers. Key to understanding chemosensory variation and health is the ability to rigorously correlate the chemosensory phenotype and genotype of patient populations who suffer from these disorders. Support for the actual research to be addressed once the requested infrastructure is in place will be sought through the Institute's P50 and R01 mechanisms. We have already made significant progress in laying the foundation for the Center's Clinical Research Program. Dr. Linda Bartoshuk has joined the faculty at UF to help plan and implement clinical research projects using newly developed and appropriate psychophysical scaling methodologies. We have established the UF Taste and Smell Clinic, where a team of clinicians see patients with chemosensory complaints. We have established collaborations with the appropriate genetics, biostatistical, and marketing personnel at UF. We have had preliminary conversations with potential collaborators outside of UF to share the technologies and capabilities we develop at UF. While the University has provided modest start up funds to conduct clinical pilot projects, several of which are now underway, we lack adequate intramural funding to implement the key infrastructure required to make the Chemosensory Clinical Research Program a success. Specifically, we propose to: (1) establish a novel core dedicated to chemosensory genetics with strengths in genotyping and statistical genetics, (2) design a novel protocol using new psychophysical tools for the clinical assessment of chemosensory function (phenotype), (3) establish a novel HIPAA compliant biostatistics and data management core, and (4) establish a novel HIPAA compliant patient and subject recruitment and management core. While the Program is resident at UF, our intent is for it to function as a 'virtual center' whereby we can easily and securely share the infrastructure we generate and the research it produces with our national and international chemosensory colleagues.
描述(由申请人提供):请求支持以建立可行性,然后实施四个基础设施组件,以扩大佛罗里达大学气味和口味中心的化学体感觉临床研究计划。该计划的重点是化学感功能障碍(口味,肾后嗅觉)和健康之间临床上重要的新兴关系。化学一致化(遗传或病理)的变化会影响食物的感觉特性以及与吸烟和酒精摄入相关的感觉。饮食,吸烟和酒精摄入是各种疾病的危险因素,包括肥胖,心血管疾病和一些癌症。理解化学感应变异和健康的关键在于能够严格关联患有这些疾病的患者群体的化学感应表型和基因型的能力。一旦所需的基础设施到位,将通过该研究所的P50和R01机制寻求对实际研究的支持。我们已经在为中心的临床研究计划奠定基础方面取得了重大进展。 Linda Bartoshuk博士已加入UF的教职员工,以新开发和适当的心理学缩放方法来帮助计划和实施临床研究项目。我们已经建立了UF的口味和气味诊所,一组临床医生看到了具有化学感应的患者。我们已经与UF的适当遗传学,生物统计学和营销人员建立了合作。我们已经与UF以外的潜在合作者进行了初步对话,以分享我们在UF开发的技术和能力。尽管该大学提供了适度的启动资金来开展临床试点项目,但其中一些正在进行中,但我们缺乏足够的壁内资金来实施使化学体感觉临床研究计划获得成功所需的关键基础设施。具体而言,我们提出:(1)建立一个新的核心,该核心专门用于化学水敏遗传学,具有基因分型和统计遗传学的优势;(2)使用新的心理物理学工具来设计一种新的协议,用于化学感知功能(phenotype)的临床评估(3)建立一个新颖的HIPAAAA A COLLAINT BIOSTATISTICS CORESTICS和IMBORCE CORPATINCE和数据管理和招募HIPA,并建立了HIPA和4)。尽管该计划居住在UF,但我们的目的是使其充当“虚拟中心”,从而可以轻松,安全地共享我们生成的基础设施及其与我们的国家和国际化学体同事所产生的研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('FRANK A CATALANOTTO', 18)}}的其他基金
University of Florida Chemosensory Clinical Research Program
佛罗里达大学化学感应临床研究项目
- 批准号:
7491681 - 财政年份:2006
- 资助金额:
$ 56.3万 - 项目类别:
University of Florida Chemosensory Clinical Research Program
佛罗里达大学化学感应临床研究项目
- 批准号:
7479427 - 财政年份:2006
- 资助金额:
$ 56.3万 - 项目类别:
University of Florida Chemosensory Clinical Research Program
佛罗里达大学化学感应临床研究项目
- 批准号:
7897724 - 财政年份:2006
- 资助金额:
$ 56.3万 - 项目类别:
University of Florida Chemosensory Clinical Research Program
佛罗里达大学化学感应临床研究项目
- 批准号:
7191993 - 财政年份:2006
- 资助金额:
$ 56.3万 - 项目类别:
NORTHEASTERN MINORITY ORAL HEALTH RESEARCH CENTER
东北少数民族口腔健康研究中心
- 批准号:
2131474 - 财政年份:1992
- 资助金额:
$ 56.3万 - 项目类别:
NORTHEASTERN MINORITY ORAL HEALTH RESEARCH CENTER
东北少数民族口腔健康研究中心
- 批准号:
3100636 - 财政年份:1992
- 资助金额:
$ 56.3万 - 项目类别:
NORTHEASTERN MINORITY ORAL HEALTH RESEARCH CENTER
东北少数民族口腔健康研究中心
- 批准号:
3100635 - 财政年份:1992
- 资助金额:
$ 56.3万 - 项目类别:
SHORT TERM TRAINING STUDENTS IN HEALTH PROF SCHOOLS
健康专业学校的短期培训学生
- 批准号:
2129674 - 财政年份:1991
- 资助金额:
$ 56.3万 - 项目类别:
SHORT TERM TRAINING STUDENTS IN HEALTH PROF SCHOOLS
健康专业学校的短期培训学生
- 批准号:
3545443 - 财政年份:1991
- 资助金额:
$ 56.3万 - 项目类别:
SHORT TERM TRAINING STUDENTS IN HEALTH PROF SCHOOLS
健康专业学校的短期培训学生
- 批准号:
2129673 - 财政年份:1991
- 资助金额:
$ 56.3万 - 项目类别:
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