Earliest predictors of language outcomes in high-risk infants

高危婴儿语言结果的最早预测因素

• 批准号: 10357782
• 负责人: Lisa Leigh Hunter
• 金额: $ 65.67万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10357782
• 关键词: 3 year old; Age; Auditory; Auditory Evoked Potentials; Biological Markers; Birth; Brain; Child; Cochlear implant procedure; Communication; Demographic Factors; Detection; Development; Diffuse; Diffusion Magnetic Resonance Imaging; Early Intervention; Early identification; Electroencephalography; Enrollment; Frequencies; Functional Magnetic Resonance Imaging; Funding; Gestational Age; Goals; Hearing; Hearing Tests; Hearing problem; High-Frequency Hearing Loss; Impairment; Infant; Intervention; Language; Language Disorders; Language Therapy; Life; Longitudinal cohort; Magnetic Resonance Imaging; Measures; Methods; Modeling; National Institute of Neurological Disorders and Stroke; Neonatal; Neurodevelopmental Disorder; Neuronal Plasticity; Newborn Infant; Nursery Schools; Outcome; Outcome Measure; Perinatal; Physiological; Premature Birth; Premature Infant; Prevalence; Prognostic Marker; Prospective Studies; Rest; Risk; Risk Factors; Sampling; Scanning; Services; Speech; Speech Disorders; Stimulus; Survivors; Therapeutic Studies; hearing impairment; hearing screening; high risk; high risk infant; improved; innovation; language outcome; literacy; neurodevelopment; novel; otoacoustic emission; permanent hearing loss; predictive modeling; response; screening; speech processing; study population; white matter

One in every nine babies in the US is born preterm. Speech, language and hearing disorders (SLD) are among the most prevalent neurodevelopmental disorders in children, especially among very preterm survivors. About 40% of very preterm infants (≤32 weeks gestational age) develop speech-language disorders while 10% have permanent hearing loss, increasing the impact on communication difficulties. Currently, it is not possible to accurately predict in the first several years of life which children will develop speech-language disorders, and speech- language therapy is the most delayed of any intervention provided to preterm infants. Such an advance would facilitate early intervention and research therapies during critical windows of optimal neuroplasticity. Our central hypothesis is that prediction of speech-language disorders is possible by 3 m corrected age (CA) with combined innovative measures of structural and functional brain connectivity with magnetic resonance imaging, evoked response measures of speech processing, and novel, sensitized hearing measures. Primary aims are to (1) Identify biomarkers of brain connectivity deficits in very preterm infants that predict SLD; (2) Identify impaired speech processing and all degrees of hearing loss in very preterm infants; and (3) Develop predictive models using advanced biomarkers in preterm infants for adverse speech, language and pre-literacy outcomes at 2 and 3 years CA. This proposal will enroll very preterm infants in a prospective study that will complete comprehensive speech-language and pre- literacy assessments at 2 and 3 years CA. and 36 m CA. The overarching goal is to develop a robust prediction model using innovative measures to enable early identification of children at high risk for SLD.

在美国，每九个婴儿就有一个早产。言语、语言和听力障碍。 （SLD）是儿童中最常见的神经发育障碍之一，尤其是 约 40% 的极早产儿（孕龄≤32 周）。 出现言语障碍，而 10% 的人患有永久性听力损失，这增加了 目前还无法在第一时间准确预测。 孩子在生命的几年里会出现语言障碍，并且语言障碍 语言治疗是为早产儿提供的所有干预措施中最延迟的。 将促进关键时期的早期干预和研究疗法的进展 我们的中心假设是言语语言障碍的预测是 结合结构和结构的创新措施，可实现 3 m 校正年龄 (CA) 功能性大脑连接与磁共振成像，诱发反应测量 语音处理和新颖的敏化听力测量的主要目标是 (1) 确定。 (2) 识别极早产儿大脑连接缺陷的生物标志物，以预测 SLD； 早产儿的言语处理受损和各种程度的听力损失；以及 (3) 使用先进的生物标志物开发早产儿不良言语的预测模型， CA 2 岁和 3 岁的语言和识字前成绩 该提案将招收非常早产的学生。 一项前瞻性研究中的婴儿将完成全面的言语和预训练 2 年和 3 年 CA 以及 36 m CA 的读写能力评估。 使用创新措施的稳健预测模型能够及早识别儿童 SLD 的高风险。