TULANE COBRE: GENETIC POLYMORPHISMS IN EPOXYGENASE PATHWAY IN HYPERTENSION

TULANE COBRE：高血压环氧合酶途径的基因多态性

• 批准号: 7610414
• 负责人: ALBERT W DREISBACH
• 金额: $ 29.31万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610414
• 关键词: Bradykinin Receptor; Computer Retrieval of Information on Scientific Projects Database; Cytochromes; Funding; Genetic Polymorphism; Grant; Human; Hypertension; Institution; Lead; Pathway interactions; Play; Research; Research Personnel; Resistance; Resources; Role; Source; Testing; United States National Institutes of Health; arachidonate; salt sensitive

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For Project 4, Dreisbach tests the hypothesis that common genetic polymorphisms in both CYP (cytochrome) arachidonate pathways and the bradykinin receptors individually or in combination lead to altered levels of 20-HETE and EETs that play a mechanistic role in salt-sensitive and salt-resistant hypertension in humans.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在项目 4 中，Dreisbach 测试了这样的假设：CYP（细胞色素）花生四烯酸途径和缓激肽受体中的常见遗传多态性单独或组合导致 20-HETE 和 EET 水平发生改变，从而在盐敏感和盐-敏感中发挥机械作用。人类顽固性高血压。