High-Resolution fMRI of Medial Temporal Lobe Mechanisms in Declarative Memory

陈述性记忆中内侧颞叶机制的高分辨率功能磁共振成像

• 批准号: 7559585
• 负责人: Anthony D Wagner
• 金额: $ 38.78万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7559585
• 关键词: Address; Alzheimer' s Disease; Anterior; Attention; Clinical; Code; Concept Formation; Coupling; Data; Dependence; Discrimination; Elements; Event; Familiarity; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Hippocampal Formation; Hippocampus (Brain); Human; Individual; Knowledge; Learning; Left; Medial; Mediating; Memory; Memory impairment; Methods; Nature; Organism; Outcome; Pattern; Performance; Population; Primates; Process; Relative (related person); Research; Research Personnel; Resolution; Response to stimulus physiology; Retrieval; Role; Schizophrenia; Sensory; Signal Transduction; Source; Stimulus; Structure; Temporal Lobe; Testing; Translating; Visual; base; blood oxygen level dependent; dentate gyrus; directed attention; experience; flexibility; forgetting; imaging modality; indexing; insight; memory encoding; mild neurocognitive impairment; novel; programs; relating to nervous system; research study; response; segregation; selective attention; theories; Address; Alzheimer' s Disease; Anterior; Attention; Clinical; Code; Concept Formation; Coupling; Data; Dependence; Discrimination; Elements; Event; Familiarity; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Hippocampal Formation; Hippocampus (Brain); Human; Individual; Knowledge; Learning; Left; Medial; Mediating; Memory; Memory impairment; Methods; Nature; Organism; Outcome; Pattern; Performance; Population; Primates; Process; Relative (related person); Research; Research Personnel; Resolution; Response to stimulus physiology; Retrieval; Role; Schizophrenia; Sensory; Signal Transduction; Source; Stimulus; Structure; Temporal Lobe; Testing; Translating; Visual; base; blood oxygen level dependent; dentate gyrus; directed attention; experience; flexibility; forgetting; imaging modality; indexing; insight; memory encoding; mild neurocognitive impairment; novel; programs; relating to nervous system; research study; response; segregation; selective attention; theories

DESCRIPTION (provided by applicant): Declarative memory permits an organism to bridge the past with the present, providing information about prior events that serves to inform present decisions and action. Declarative memory critically depends on the medial temporal lobe (MIL), which is composed of the hippocampal formation (dentate gyrus, fields of cornu Ammonis, and subiculum) and the surrounding entorhinal, perirhinal, and parahippocampal cortices. Though decades of research have aimed to characterize the role of MIL in declarative memory, fundamental questions remain regarding the functional contributions of specific MTL substructures. Recent advances in functional imaging have now made it possible to begin to address these questions in humans. The proposed research will use high-resolution functional MRI and anatomically-based analysis methods to delineate the role of specific MTL cortical and hippocampal subfields in declarative memory. The proposed experiments will test anatomically-informed theory-driven hypotheses regarding the nature of declarative memory and its dependence on MTL function. Expts 1-3 will examine novelty-encoding processes in the anterior/posterior and coronal axes of MTL, focusing on whether content-sensitive encoding effects are present within distinct MTL cortices and hippocampal subfields. Expts 4-9 will explore the function of MTL substructures and their interactions during declarative memory encoding and retrieval, focusing on decomposition of mechanisms that support conjunctive and item memory. Expts 10-12 will test hypotheses about the nature of MTL retrieval mechanisms signaling item familiarity and temporal recency, including their dependence on study- test perceptual similarity. Expts 13-14 will examine how hippocampal and MTL cortical encoding mechanisms that encode item and conjunctive memories are impacted by goal-directed attention, including attention-dependent enhancement and suppression of MTL responses. The basic knowledge to be gained from this programmatic effort to test theory-driven hypotheses of declarative memory and MTL substructure function promises to yield new insights into the nature of learning and memory impairments in clinical populations. Declarative memory deficits accompany a number of clinical conditions, including schizophrenia, mild cognitive impairment, and Alzheimer's disease. We will directly translate the obtained outcomes to inform our collaborative studies of MTL dysfunction in schizophrenia.

描述（由申请人提供）：声明性记忆允许有机体用现在桥接过去，提供有关以前事件的信息，这些事件有助于为当前的决策和行动提供信息。声明性记忆严重取决于颞叶（MIL），该颞叶（MIL）由海马形成（齿状回，Cornu Ammonis和subiculum的田地）以及周围的内hinal骨，支出，支出和偏头皮层。尽管数十年的研究旨在表征MIL在声明性记忆中的作用，但有关特定MTL子结构的功能贡献仍然存在基本问题。现在，功能成像的最新进展使得开始在人类中开始解决这些问题。拟议的研究将使用高分辨率功能MRI和基于解剖的分析方法来描述特定MTL皮质和海马子场在声明性记忆中的作用。提出的实验将测试有关声明性记忆的性质及其对MTL功能的解剖学理论驱动的假设。 Expts 1-3将检查MTL前/后/后轴和冠状轴的新颖性编码过程，重点是在不同的MTL皮层和海马子场中是否存在含量敏感的编码效果。 Expts 4-9将探索MTL子结构的功能及其在声明内存编码和检索过程中的功能，重点关注支持结合性和项目存储器的机制的分解。 Expts 10-12将测试有关MTL检索机制的性质信号的假设，该假设是信号的熟悉度和时间长期的，包括其依赖研究检验感知相似性。 expts 13-14将研究海马和MTL皮质编码机制如何编码项目和结合记忆受到目标指导注意的影响，包括依赖注意力的增强和抑制MTL响应。从这项计划的努力中获得的基本知识，以测试由理论驱动的声明性记忆和MTL亚结构功能的假设，有望产生对临床人群中学习和记忆障碍本质的新见解。声明性记忆缺陷伴随着许多临床状况，包括精神分裂症，轻度认知障碍和阿尔茨海默氏病。我们将直接翻译获得的结果，以告知我们对精神分裂症中MTL功能障碍的协作研究。