STUDY OF ACID REFLUX AND ASTHMA (SARA TRIAL)

胃酸反流和哮喘的研究（SARA 试验）

• 批准号: 7604272
• 负责人: Lewis J Smith
• 金额: $ 2.28万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604272
• 关键词: STUDY; ACID; REFLUX; ASTHMA; SARA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma and Gastroesophageal Reflux Disease (GERD) are common disorders, usually non-lethal, but with high morbidity and healthcare costs. Asthma occurs in about 4%-7% of the US population, and GERD symptoms occur daily in approximately 7%-20% of US adults. The co-existence of asthma and GERD is far more frequent than chance association. GERD symptoms, although usually mild, occur in up to 65-77% of asthmatics. Often, GERD is "silent" in asthmatics as well, lacking typical symptoms such as heartburn. GERD is particularly frequent in asthmatics with poor asthma control and can induce bronchoconstriction. Poorly controlled asthmatics are often treated for GERD with drugs that suppress gastric acid but this treatment is expensive and the benefit of such treatment is not established. The objective of this study is to conduct a multi-site randomized clinical trial testing the hypothesis that treatment of GERD with proton-pump inhibitors will reduce the frequency of exacerbations in patients with inadequately controlled asthma.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 哮喘和胃食管反流疾病（GERD）是常见的疾病，通常是非致死性的，但发病率高和医疗保健成本。 哮喘发生在约4％-7％的美国人群中，而GERD症状每天发生在美国大约7％-20％的美国成年人中。 哮喘和GERD的共存比偶然的关联要频繁得多。 GERD症状虽然通常是轻度，但最多65-77％的哮喘患者出现。 通常，GERD在哮喘患者中也“沉默”，缺乏诸如胃灼热之类的典型症状。 GERD在哮喘控制差的哮喘患者中尤其频繁，可以诱导支气管收缩。 控制不良的哮喘患者通常会用抑制胃酸的药物治疗GERD，但这种治疗量昂贵，并且无法确定这种治疗的好处。 这项研究的目的是进行一项多站点随机临床试验，该试验检验以下假设：用质子泵抑制剂治疗GERD将减少无法充分控制哮喘患者加重的频率。