A COUNTERMEASURE FOR SLEEP LOSS IN OLDER ADULTS

老年人睡眠不足的对策

• 批准号: 7604254
• 负责人: Phyllis C. Zee
• 金额: $ 5.53万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604254
• 关键词: COUNTERMEASURE; SLEEP; LOSS; OLDER; ADULTS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of chronic insomnia increases with age. Recent findings demonstrate that in addition to its detrimental effects on cognition and performance, sleep loss also has a negative impact on health that is similar to age-related changes in metabolic, cardiovascular, and immune measures of health. Despite the important medical and social consequences of chronic sleep loss that accompany the aging process, there is a paucity of safe and effective treatment strategies for the elderly. The chronic nature of the sleep problems, coupled with the side effects of hypnotic medications, limit the usefulness of pharmacological approaches for the treatment of insomnia in this older population. Therefore, there is a need to develop alternative, safe and effective approaches for the management of insomnia in older adults. Recent findings indicate that exercise can improve sleep quality in older adults. The goal of the proposed research is to determine the ability of exercise to improve sleep, health, daytime performance and overall quality of life in older adults with insomnia. Specific aim 1 is to determine the effects of exercise and sleep hygiene education on objective and subjective measures of sleep quality, sleep quantity, circadian rhythms, daytime performance, mood and quality of life in older adults with insomnia. These objective and subjective measures will be taken during a 3-day admission to the General Clinical Research Center before and after a 16-week aerobic exercise program (3-4 sessions per week). The same measures will be taken in a control group before and after a 16-week sleep hygiene education intervention with structured activity. Specific aim 2 is to determine the effects of the aerobic exercise and improvements in sleep quality and quantity on measures of health. Measurements of metabolic, endocrine and cardiovascular, as well as other bio-markers of aging such as bone turnover, autonomic and immune parameters (IL-6, TNF-alpha and C-reactive protein) will be taken before and after the 16-week exercise intervention or sleep hygiene education intervention. The proposed studies will not only determine whether exercise is an effective approach for the management of insomnia in the elderly, but will also improve our understanding of the relationship between sleep and health in older adults.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 慢性失眠的患病率随着年龄的增长而增加。 最近的发现表明，除了对认知和表现的有害影响外，睡眠丧失还对健康也具有负面影响，这类似于与年龄相关的代谢，心血管和免疫健康措施的变化。 尽管伴随衰老过程伴随着慢性睡眠损失的重要医学和社会后果，但对于老年人来说，安全有效的治疗策略很少。 睡眠问题的慢性性质，再加上催眠药的副作用，限制了药理学方法在该老年人群中治疗失眠的有用性。 因此，有必要开发替代，安全有效的方法来管理老年人的失眠症。 最近的发现表明，运动可以改善老年人的睡眠质量。 拟议研究的目的是确定运动能够改善失眠症老年人睡眠，健康，白天表现和整体生活质量的能力。 具体目的1是确定运动和睡眠卫生教育对睡眠质量，睡眠数量，昼夜节律，白天表现，情绪和失眠年轻人生活质量的影响的影响。 这些客观和主观的措施将在为期16周的有氧运动计划（每周3-4次）之前和之后的为期3天的通用临床研究中心接受（每周3-4次）。 在对照组进行16周睡眠卫生教育干预措施之前和之后，将采取相同的措施。 具体目标2是确定有氧运动的影响以及睡眠质量和数量对健康度量的影响。 代谢，内分泌和心血管的测量以及其他衰老的生物标志物，例如骨转换，自主和免疫参数（IL-6，TNF-α，TNF-Alpha和C反应蛋白），请在16周的运动干预或睡眠卫生卫生教育介入之前和之后进行。 拟议的研究不仅将确定运动是否是老年失眠的有效方法，而且还将提高我们对老年人睡眠与健康之间关系的理解。