CHILDREN'S MEMORIAL FOOD ALLERGY STUDY

儿童纪念食物过敏研究

• 批准号: 7604301
• 负责人: XIAOBIN WANG
• 金额: $ 33.54万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604301
• 关键词: CHILDREN; MEMORIAL; FOOD; ALLERGY; STUDY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The causes of food allergy are largely unknown. However, based on available epidemiological, clinical, and laboratory research, food allergy appears to be a complex trait and may be affected by both prenatal and postnatal environmental factors as well as genetic factors. The overall goal of this study is to better understand natural history of food allergy and the role of prenatal and postnatal environmental factors as well as genetic factors in the development and prognosis of food allergy. We also hope to identify novel serum and genetic biomarkers for more accurate means of defining food allergy subtypes, prognosis, and therapeutic targets. We propose to conduct a multi-site observational study with the goal to better understand the natural history and etiology of food allergy by analyzing and integrating data from three complementary study cohorts. Specifically, we hope: 1. To prospectively follow the existent birth cohort at Boston Medical Center (BMC), ~3,000 mother-infant pairs. The Boston birth cohort is well suited for assessing the impact of prenatal and postnatal environment factors, susceptible genes, and cord blood biomarkers in relation to food allergy development and prognosis in childhood. The field data collection procedures are similar to the current CMH IRB protocol # 2004-12324 "BMC Children's Health Study," except that we would like to add (1) additional questions on food allergy in the questionnaire and medical record abstraction; and (2) skin prick test and to measure additional biomarkers related to food allergy. The "BMC Children's Health Study" also has received IRB approval from the Boston University Medical Center. 2. To prospectively follow the existing Chinese twin cohort of about 2000 twin pairs (4,000 subjects) that are 6 years of age and older; Chinese twin cohort offers an ideal tool to estimate heritability (relative role of environmental and genetic factors) of food allergy. The field data collection procedures are similar to the current CMH IRB protocol # 2005-12438 "Epidemiology of Metabolic Syndrome in Children," except that we would like to add (1) additional questions on food allergy in the questionnaire; (2) a skin prick test and to measure additional biomarkers for food allergy. The "Epidemiology of Metabolic Syndrome in Children" also has received IRB approval from the Anhui Medical University in China 3. To establish a prospective clinical cohort at Children's Memorial Hospital, including about 450 nuclear families with at least one child having food allergy (case families) and about 450 control families without any food allergies. The Chicago clinical cohort can serve as an independent population for validating the findings from Boston and Chinese cohorts and lay the foundation for future translational research. The field data collection procedures include: (1) a questionnaire interview; (2) a medical record review; (3) venous blood sample collection and a test of biomarkers for food allergy; (4) a skin prick test; and (5) a pulmonary function test among study subjects aged 6 or older. The unique strength of this study is that it will be conducted as an in-depth cross-sectional and longitudinal investigation on inter-relations and temporal relations among both established and novel food allergy phenotypes and will explore the role of environmental and genetic factors in the development and prognosis of food allergy. This study represents an opportunity to integrate data from three complementary study cohorts. Scientifically, it is ideal to utilize one population for discovery, and to use another for confirmation. These three cohorts together will create a unique and rich database for developing new research initiatives and competing for NIH and other extramural grants.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 食物过敏的原因在很大程度上是未知的。 但是，基于可用的流行病学，临床和实验室研究，食物过敏似乎是一个复杂的特征，可能受到产后和产后环境因素以及遗传因素的影响。 这项研究的总体目的是更好地了解食物过敏的自然史以及产后和产后环境因素的作用以及遗传因素在食物过敏的发展和预后中。 我们还希望鉴定新的血清和遗传生物标志物，以更准确地定义食物过敏亚型，预后和治疗靶标。 我们建议进行一项多站点的观察性研究，以更好地了解食物的自然历史和病因 通过分析和整合来自三个互补研究队列的数据来过敏。 具体来说，我们希望： 1。前瞻性地遵循波士顿医疗中心（BMC）现有的出生队列，约3,000对母亲。 波士顿出生队列非常适合评估产后和产后环境因素，易感基因和脐带血生物标志物在童年时期与食物过敏和预后有关的影响。 现场数据收集程序类似于当前的CMH IRB协议＃2004-12324“ BMC儿童健康研究”，只是我们想添加（1）关于食物过敏的其他问题，并在问卷和医疗记录抽象中添加了其他问题； （2）皮肤刺测试并测量与食物过敏相关的其他生物标志物。 “ BMC儿童健康研究”还获得了波士顿大学医学中心的IRB批准。 2。前瞻性地遵循现有的中国双胞胎队列，约有2000个双胞胎对（4,000名受试者），年龄在6岁及以上； 中国双胞胎队列提供了食物过敏的遗传力（环境和遗传因素的相对作用）的理想工具。 现场数据收集程序类似于当前的CMH IRB协议＃2005-12438“儿童代谢综合征的流行病学”，只是我们想在问卷中添加（1）有关食物过敏的其他问题； （2）皮肤刺测试并测量食物过敏的其他生物标志物。 “儿童代谢综合症的流行病学”也已获得中国安武医科大学的IRB批准 3。在儿童纪念医院建立一个前瞻性的临床队列，其中包括至少一个患有食物过敏的儿童（病例家族）和大约450个控制家庭的核心家庭，而没有任何食物过敏。 芝加哥临床队列可以作为独立人群来验证波士顿和中国人群的发现，并为未来的转化研究奠定基础。 现场数据收集程序包括：（1）问卷采访； （2）病历审查； （3）静脉血液样本收集和食物过敏的生物标志物测试； （4）皮肤刺测试； （5）在6岁或以上的研究对象之间进行肺功能测试。 这项研究的独特优势在于，它将作为对已建立和新颖的食物过敏表型之间的相互关系和时间关系的深入横截面和纵向研究，并将探索环境和遗传因素在食物过敏症的发展和预后中的作用。 这项研究代表了整合来自三个互补研究队列的数据的机会。从科学上讲，使用一个人群进行发现，并使用另一个人群进行确认是理想的选择。 这三个队列将共同创建一个独特而丰富的数据库，用于制定新的研究计划并争夺NIH和其他壁外赠款。