JUVENILE DERMATOMYOSITIS: CLINICAL CORRELATES OF VASCULAR DISEASE

青少年皮肌炎：血管疾病的临床相关性

• 批准号: 7604334
• 负责人: LAUREN M. PACHMAN
• 金额: $ 0.23万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604334
• 关键词: JUVENILE; DERMATOMYOSITIS; CLINICAL; CORRELATES; VASCULAR

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adult patients with a history of Juvenile Dermatomyositis (JDM) will have evidence for diffuse vasculopathy, the severity of which will correlate with the presence of dystrophic calcification, with the TNF-308A allele and other measures of inflammation, and with traditional risk factors for cardiovascular disease. The specific aims of this study are to characterize 10-30 adults, at least 21 years of age, and diagnosed with JDM at least ten years previously, with respect to: a. Clinical Disease Activity Score (DAS): total, skin and muscle b. Glucose metabolism: to assay for insulin resistance by a two glucose tolerance tests. c. Vascular disease: nailfold capillary studies, carotid intimal media thickness (CIMT), coronary calcium score by electron beam computerized tomography (EBCT). d. Indicators of inflammation: TNF-308A, serum amyloid, and hsCRP. e. Lipid metabolism: Fasting Lp(a): Cholesterol, HDL, LDL, LPAC, VLAC, TGLM (medium chain triglycerides), ApoA1, ApoB, triglycerides. f. Hormonal: DHEAS (males and females); LH, FSH, total testosterone (females).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 有幼年性皮肌炎 (JDM) 病史的成年患者将有弥漫性血管病变的证据，其严重程度与营养不良性钙化的存在、TNF-308A 等位基因和其他炎症指标以及传统的心血管危险因素相关疾病。 本研究的具体目的是描述 10-30 名至少 21 岁且至少在 10 年前被诊断患有 JDM 的成年人的特征，涉及以下方面： 一个。临床疾病活动评分 (DAS)：总评分、皮肤评分和肌肉评分 b.葡萄糖代谢：通过两次葡萄糖耐量试验来测定胰岛素抵抗。 c.血管疾病：甲襞毛细血管研究、颈动脉内膜中层厚度（CIMT）、电子束计算机断层扫描（EBCT）冠状动脉钙化评分。 d.炎症指标：TNF-308A、血清淀粉样蛋白和 hsCRP。 e.脂质代谢：空腹 Lp(a)：胆固醇、HDL、LDL、LPAC、VLAC、TGLM（中链甘油三酯）、ApoA1、ApoB、甘油三酯。 f.荷尔蒙：DHEAS（男性和女性）； LH、FSH、总睾酮（女性）。