Preconceptional health of Latinas and its association with child adiposity

拉丁裔的孕前健康状况及其与儿童肥胖的关系

基本信息

批准号：
10188517
负责人：
ANNA MARIA SIEGA-RIZ
金额：
$ 60.06万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-18 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10188517
关键词：
5 year old Accounting Acculturation Address Adult Affect Age Ancillary Study Anthropometry Behavior Behavioral Biological Biological Markers Blood Pressure Body Weight Body fat Child Child Rearing Cities Clinic Visits Complex Conceptions Data Development Diet Disease Documentation Dual-Energy X-Ray Absorptiometry Eating Eating Behavior Ensure Environment Family Fatty acid glycerol esters Food Future Genetic Genetic Predisposition to Disease Health Health Status Health behavior Height High Density Lipoprotein Cholesterol High Prevalence High birth weight infant Hispanic Community Health Study/Study of Latinos Hispanics Home Hyperphagia Income Infant Insulin Intervention Intervention Studies Latina Latino Life Life Style Link Low income Maternal Health Measures Mental Health Metabolic dysfunction Minority Groups Modeling Mothers National Health and Nutrition Examination Survey Not Hispanic or Latino Obesity Overweight Parents Perinatal Personal Satisfaction Physical activity Prevalence Protocols documentation Psychological Stress Public Health Randomized Controlled Trials Recording of previous events Reproductive History Research Rewards Risk Risk Factors Role Social Behavior Sociology Standardization Time Triglycerides United States Visit Weight Weight Gain Woman cardiometabolic risk cardiometabolism cardiovascular health cohort depressive symptoms design fasting glucose feeding food environment improved maternal obesity metabolic profile middle childhood mother nutrition novel obesity development obesity in children obesity risk offspring offspring obesity prenatal prepregnancy prevent prospective psychosocial recruit reproductive sedentary lifestyle sleep behavior sociodemographics therapy development waist circumference

项目摘要

Abstract: Hispanic children have a higher prevalence of overweight/obesity than their non-Hispanic counterparts. Perinatal maternal health status and lifestyle behaviors are recognized as important risk factors for childhood obesity. Pre-pregnancy maternal obesity is linked to higher infant birth weight and increased risk of offspring obesity. The maternal diet and metabolic profile during preconception has been shown to adversely affect the subsequent health of the offspring, including the development of obesity. However, the data are scarce for Hispanics from various backgrounds and limited, in general, due to the lack of standardized documentation of preconception health. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a cohort of 16,415 adults (including 3,801 women 18-44y) from four U.S. cities, is the largest health study of Hispanics/Latinos in the US. Baseline data, including cardiometabolic markers and diet, were collected from 2008 to 2011, and reproductive history is being collected at visit 2 from October 2014 to 2017. Hence, HCHS/SOL offers a unique opportunity to prospectively investigate the role of preconceptional maternal health status (cardiometabolic biomarkers and diet) on the development of childhood obesity and to understand drivers of overeating, such as food reward-related behaviors and psychological stress of women as predictors of child feeding practices and weight. This ancillary study proposes to recruit 440 mother-child dyads; these are women of reproductive age with a child (ages 3-7y) born since the baseline examination to assess child's weight, height and adiposity (total fat mass as measured by DEXA), eating and other lifestyle behaviors, and women's food reward-related behaviors. We propose to identify early modifiable determinants of child's weight and adiposity status that are not attributable to the genetic environment. This is a novel use of an existing cohort to answer very timely and important research questions that have the ability to contribute to the development of intervention studies during this very critical time period in the lifecycle of both the mother and child for the Hispanic population.

抽象的：西班牙裔儿童的超重/肥胖发生率高于非西班牙裔儿童同行。围产期孕产妇健康状况和生活方式行为被认为是儿童肥胖的重要危险因素。孕前肥胖与较高的妊娠期肥胖有关婴儿出生体重和后代肥胖的风险增加。产妇的饮食和代谢孕前的个人资料已被证明会对随后的健康产生不利影响后代，包括肥胖的发展。然而，西班牙裔的数据很少由于缺乏标准化，背景各异且有限孕前健康记录。西班牙裔社区健康研究/研究拉丁美洲人 (HCHS/SOL)，由来自四个美国国家的 16,415 名成年人（包括 3,801 名 18-44 岁女性）组成的队列城市，是美国最大的西班牙裔/拉丁裔健康研究。基线数据，包括 2008 年至 2011 年收集心脏代谢标志物和饮食，生殖史为是在 2014 年 10 月至 2017 年第 2 次访问时收集的。因此，HCHS/SOL 提供了独特的有机会前瞻性地研究孕前孕产妇健康状况的作用（心脏代谢生物标志物和饮食）对儿童肥胖的发展和了解暴饮暴食的驱动因素，例如与食物奖励相关的行为和心理妇女的压力作为儿童喂养方式和体重的预测因素。这项辅助研究拟招募440名母子情侣；这些是有孩子的育龄妇女（3-7 岁）自基线检查以来出生，以评估儿童的体重、身高和肥胖程度（通过 DEXA 测量的总脂肪量）、饮食和其他生活方式行为以及女性食品与奖励相关的行为。我们建议确定儿童体重的早期可改变决定因素以及与遗传环境无关的肥胖状况。这是一个新颖的用途现有的队列能够回答非常及时和重要的研究问题，并且有能力在这个非常关键的时期为干预研究的发展做出贡献西班牙裔人口的母亲和孩子的生命周期。