EXERCISE & URIC ACID LEVELS IN MULTIPLE SCLEROSIS PATIENTS

锻炼

• 批准号: 7604435
• 负责人: JOHN R CORBOY
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604435
• 关键词: Antioxidants; Circadian Rhythms; Computer Retrieval of Information on Scientific Projects Database; Exercise; Exposure to; Free Radicals; Funding; Grant; Heating; Institution; Multiple Sclerosis; Oxidative Stress; Patients; Research; Research Personnel; Resources; Source; Time; United States National Institutes of Health; Uric Acid; day

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Uric acid is an endogenous antioxidant, and is the primary scavenger of an important free radical which has been implicated in several studies as causing some of the damage to the CNS in MS. For unclear reasons, MS patients have lower levels of uric acid than normal controls. Uric acid maintains a typical circadian rhthym, but in normal controls is increased in times of increased oxidative stress, including exercise and exposure to heat. MS patients?We are wondering how MS patients respond to the oxidative stress of exercise in terms of whether or not they are able to raise their uric acid levels appropriately. We want to exercise MS patients, and then check successive uric acid levels throughout the day, and compare this with normal controls.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 尿酸是一种内源性抗氧化剂，是重要的自由基的主要清除剂，它与几项研究有关，导致了MS中CNS的某些损害。由于不清楚的原因，MS患者的尿酸水平低于正常对照。尿酸保持典型的昼夜节律，但在正常对照中，氧化应激增加，包括运动和暴露于热量。 MS患者？我们想知道MS患者对运动的氧化应激有何反应，因为他们是否能够适当地提高其尿酸水平。我们想运动MS患者，然后全天检查连续的尿酸水平，并将其与正常对照组进行比较。