Texas NeuroAIDS Research Center

德克萨斯神经艾滋病研究中心

基本信息

批准号：
10353375
负责人：
BENJAMIN B. GELMAN
金额：
$ 126.51万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-05-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10353375
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Adherence Age Aging Applications Grants Automobile Driving Autopsy Basic Science Biological Assay Biological Markers Biological Specimen Banks Blood specimen Brain Censuses Cerebrospinal Fluid Certification Characteristics Chemicals Clinic Clinic Visits Clinical Clinical Data Clinical Sciences Cognition Disorders Communities Data Data Coordinating Center Diagnosis Elderly Ensure Equipment and supply inventories Evaluation Frequencies Future Gender Gene Expression Goals HIV HIV Infections HIV Seronegativity HIV-associated neurocognitive disorder Health Human Immunologics Immunosuppression Impairment Individual Information Management Informed Consent Investigation Investigator-Initiated Research Lead Longitudinal cohort Measurement Measures National NeuroAids Tissue Consortium Neurologic Neurologic Dysfunctions Neurologic Examination Neuropsychological Tests Neuropsychology Participant Pathologic Pathology Patient Self-Report Patients Persons Population Procedures Prognosis Protocols documentation Reaction Time Reporting Research Research Personnel Resources Risk Schedule Site Specimen Spinal Puncture Standardization Structure Substance abuse problem Surveys System Testing Texas Time Tissue Banks Tissues Training U-Series Cooperative Agreements United States National Institutes of Health Universities Viral Viral Load result Viral reservoir Virus Replication Visit age related base clinical research site clinically relevant cohort data resource distributed data gulf coast high risk human tissue in vivo innovation latent HIV reservoir mortality neuroAIDS neurocognitive disorder neuropathology older patient operation programs quality assurance recruit repository response substance use synergism therapeutic target tissue resource

项目摘要

Abstract The National NeuroAIDS Tissue Consortium (NNTC) is a collaborative tissue and data resourcing program in which the Texas NeuroAIDS Research Center (TNRC; B. Gelman, PI) has participated since inception in 1998. The NNTC's purpose is to collect and distribute critical clinical data and tissue specimens from longitudinally- tracked HIV-infected individuals at high risk for HIV-associated neurocognitive disorders (HAND), to support innovative and transformative investigator-initiated research in the NeuroAIDS community-at-large. The NNTC patient cohort is unique because it is the sole pathology-focused longitudinal cohort in the HIV field. The consortium has helped to heightened the relevancy of research overall in the field. Beyond supplying tissue specimens the TNRC provides researchers access to relevant in vivo biomarkers, viral loads, gene expression data, neuropathological changes, and associated HAND cognitive status. This enables clinical and basic science-level researchers to incorporate these critical measures into investigations of the mechanisms driving HAND, HIV-associated pathological effects of HIV infection, or potential HAND therapeutic targets. In past cycles the NNTC has supported hundreds of research reports and grant applications, and would continue to do that into the future. The broad aim of the current TNRC application is to continue the cooperative agreement with other Clinical sites and the NIH, to provide such resources derived from locally-recruited (Texan) HIV patients, and to focus this local resource to address changing and future resource needs of the NeuroAIDS community. The TNRC patient cohort will focus in the future on the aging of the HIV population in the USA, which could inform about how age influences HIV-associated neuropsychological and neurological dysfunction. TNRC will emphasize providing tissue specimens to define the characteristics of the latent HIV reservoirs in the deep body compartments of virally suppressed people. Application for continued support to operate the Texan NNTC clinic site addresses all aspects of the general operating procedures of the TNRC. We describe recruiting practices, neuropsychological evaluations, substance use surveys, neuromedical protocols, autopsy procedure, and specimen repository management. We present proposed strategies to contribute to consortium-wide goals and to obtain synergy with the other units of the NNTC. Continued operation of NNTC and the TNRC will have a lasting and positive impact on the search for remedies for HAND, CNS aging, CNS latent HIV reservoirs and many other HIV-associated pathological conditions.

抽象的国家神经艾滋病组织联盟 (NNTC) 是一个协作组织和数据资源计划德克萨斯州神经艾滋病研究中心 (TNRC; B. Gelman, PI) 自 1998 年成立以来一直参与其中。 NNTC 的目的是收集和分发来自纵向的关键临床数据和组织样本。追踪艾滋病毒相关神经认知障碍 (HAND) 高风险的艾滋病毒感染者，以支持由研究者在整个 NeuroAIDS 社区发起的创新和变革性研究。国家核技术委员会患者队列是独一无二的，因为它是艾滋病毒领域唯一以病理学为重点的纵向队列。这联盟帮助提高了该领域整体研究的相关性。除了供应组织之外 TNRC 为研究人员提供相关的体内生物标志物、病毒载量、基因表达的标本数据、神经病理学变化和相关的 HAND 认知状态。这使得临床和基础科学水平的研究人员将这些关键措施纳入驱动机制的研究中 HAND、HIV 感染的 HIV 相关病理效应或潜在的 HAND 治疗靶点。过去 NNTC 已支持数百份研究报告和拨款申请，并将继续这样做那到未来。当前 TNRC 申请的总体目标是延续合作协议与其他临床中心和 NIH 合作，提供来自当地招募的（德克萨斯州）艾滋病毒的资源患者，并集中本地资源来满足 NeuroAIDS 不断变化的和未来的资源需求社区。 TNRC 患者队列未来将重点关注美国艾滋病毒人口的老龄化问题，这可以了解年龄如何影响与艾滋病毒相关的神经心理和神经功能障碍。 TNRC 将强调提供组织样本来确定潜伏 HIV 病毒库的特征病毒受到抑制的人的深层身体隔室。申请继续支持运营德克萨斯州 NNTC 诊所站点涵盖 TNRC 一般操作程序的所有方面。我们描述招募实践、神经心理学评估、物质使用调查、神经医学方案、尸检程序和样本库管理。我们提出了拟议的战略，以促进联盟范围内的目标，并与 NNTC 的其他单位取得协同作用。 NNTC继续运营 TNRC 将对寻找 HAND、CNS 老化、CNS 治疗方法产生持久和积极的影响潜在的艾滋病毒储存库和许多其他与艾滋病毒相关的病理状况。