NCANDA Research Project Site: Duke

NCANDA 研究项目地点：杜克大学

• 批准号: 10187464
• 负责人: DAVID B. GOLDSTON
• 金额: $ 60.03万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2022-08-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10187464
• 关键词: Abstinence; Acute; Address; Adolescence; Adolescent; Adolescent Development; Adolescent and Young Adult; Adult; Adverse effects; Affective; Age; Alcohol consumption; Alcohols; Area; Behavior assessment; Behavioral; Biological; Brain; Chronic; Clinical assessments; Cognitive; Collection; Corpus striatum structure; Data; Development; Dose; Education; Employment; Environment; Event; Foundations; Functional Magnetic Resonance Imaging; Health; Heavy Drinking; Human; Individual; Legal; Life; Magnetic Resonance Imaging; Mediating; Mental Health; Mental disorders; Monitor; Neurobiology; Neurocognitive; Outcome; Parietal; Participant; Pattern; Phase; Prevention program; Psychosocial Factor; Public Policy; Recording of previous events; Recovery; Regulation; Reporting; Research Project Grants; Rewards; Risk; Sampling; Sex Differences; Sex Differentiation; Site; Statistical Models; Stress; Structure; Substance Use Disorder; Symptoms; System; Teenagers; Variant; Visit; Work; Youth; age effect; alcohol consequences; alcohol effect; alcohol expectancy; alcohol exposure; alcohol measurement; alcohol risk; binge drinking; cognitive control; cognitive development; cognitive testing; cohort; depressive symptoms; drinking; drinking onset; emerging adult; experience; externalizing behavior; information processing; longitudinal analysis; longitudinal design; multimodality; neural circuit; neurodevelopment; neuroimaging; neurotoxic; psychobiologic; psychologic; relating to nervous system; resilience; response; sex; substance use; twelfth grade; underage drinking; young adult

PROJECT SUMMARY During young adulthood, drinking dramatically increases, with binge-level drinking peaking at age 22 and nearly half of individuals reporting binge-level alcohol use. Frequent binge alcohol use during the protracted neuromaturation spanning into the mid-20s may result in greater brain and cognitive effects than similar alcohol use in later adulthood. In response to RFA-AA-17-003, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2) to determine the predictors and effects of heavy adolescent alcohol use in adolescence and young adulthood. To achieve this, the Duke site of NCANDA-2 will continue to follow a cohort of 175 in the Raleigh-Durham, NC area (n=831 across all 5 sites) participants (ages 12-21 at baseline first visit) to acquire the necessary data to advance our understanding of adolescent development and the effects of alcohol use during adolescence on the adult brain. NCANDA-2 will use multimodal neuroimaging, cognitive testing, behavioral assessment, biospecimen collection, and multimodal assessments in the natural environment. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence and young adulthood, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, the UCSD site will collaborate with the Duke and OHSU sites to study recovery of these abnormalities. Specifically, we will examine the degree to which targeted heavy drinking related neurocognitive and brain integrity deficits remit over 4 weeks of monitored abstinence. Duke will also collaborate with the Pittsburgh site to examine the influence of alcohol use on reward and inhibitory systems with longitudinal analyses of a rewarded antisaccade task to evaluate changes in these systems for youth who increase drinking versus those who do not. Sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors (e.g., depression symptoms) will be considered in analyses. With the additional longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities and resiliencies that may alter adolescents’ and young adults’ risk for alcohol or other substance use disorder and other mental health and developmental outcomes.

项目概要 在成年早期，饮酒量急剧增加，酗酒水平在 22 岁时达到顶峰， 近一半的人报告在长期酗酒期间经常酗酒。 跨越 20 多岁的神经成熟期可能会比类似的情况对大脑和认知产生更大的影响 为了回应 RFA-AA-17-003，本申请提出了一个研究项目。 国家青少年酒精与神经发育联盟第二阶段 (NCANDA-2) 网站 确定青春期和成年早期青少年大量饮酒的预测因素和影响。 为了实现这一目标，NCANDA-2 的杜克站点将继续跟踪北卡罗来纳州罗利-达勒姆的 175 名队列 区域（所有 5 个地点的 n=831 名）参与者（基线首次访问时年龄为 12-21 岁），以获取必要的数据 我们对青少年发展以及青春期饮酒对健康的影响的理解 NCANDA-2 将使用多模式神经影像、认知测试、行为评估、 生物样本采集以及自然环境中的多模式评估酒精检查。 后果将集中于在此期间积极发育的大脑区域的结构和功能成熟。 青春期和成年早期，参与心理调节，对奖励做出反应，并出现 此外，加州大学圣地亚哥分校网站将与杜克大学和 OHSU 合作。 具体来说，我们将检查目标重度的恢复程度。 饮酒相关的神经认知和大脑完整性缺陷在 4 周的杜克监测戒酒后得到缓解。 还将与匹兹堡网站合作，研究饮酒对奖赏和抑制的影响 对奖励性反眼跳任务进行纵向分析的系统，以评估这些系统的变化 增加饮酒的青少年与不增加饮酒的青少年在发育、饮酒模式方面存在性别差异。 和病史、饮酒对大脑的影响以及性别差异心理社会因素（例如抑郁症） 症状）将在分析中予以考虑。 将确定酒精暴露对青少年大脑发育轨迹的影响， 并确定可能改变青少年和年轻人的先前存在的心理生物学脆弱性和弹性 成人酒精或其他物质使用障碍以及其他心理健康和发育结果的风险。